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2012 Fiscal Year Final Research Report

Detection of methylglyoxal-modified Hsp27 and its role of colon carcinogenesis

Research Project

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Project/Area Number 22590705
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

NAITO Yuji  京都府立医科大学, 医学(系)研究科, 准教授 (00305575)

Co-Investigator(Kenkyū-buntansha) TAKAGI Tomohisa  京都府立医科大学, 医学(系)研究科, 講師 (70405257)
ITO Tomoko (OYA Tomoko)  京都府立医科大学, 医学(系)研究科, 准教授 (80329648)
Project Period (FY) 2010 – 2012
Keywords大腸癌 / 熱ショックタンパク質 / メチルグリオキザール / 翻訳後修飾 / アポトーシス
Research Abstract

Methylglyoxal (MG) is a reactive dicarbonyl compound produced from cellular glycolytic intermediates that reacts non-enzymatically with proteins. We found that heat shock protein 27 (Hsp27) was modified by MG in patients with cancers of ascending colon and rectum, but in non-cancerous cell lines or in normal subject. MG modification of Hsp27 protected the cells against apoptotic signaling. Our results suggest that posttranslational modification of Hsp27 by MG may have important implications for colon carcinogenesis.

  • Research Products

    (63 results)

All 2013 2012 2011 2010 Other

All Journal Article (52 results) (of which Peer Reviewed: 52 results) Presentation (10 results) Remarks (1 results)

  • [Journal Article] A novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise2013

    • Author(s)
      Aoi W, Naito Y, Takagi T, Tanimura Y, Takanami Y, Kawai Y, Sakuma K, Hang LP, Mizushima K, Hirai Y, Koyama R, Wada S, Higashi A, Kokura S, Ichikawa H, Yoshikawa T.
    • Journal Title

      Gut

      Volume: 62 Pages: 882-9

    • Peer Reviewed
  • [Journal Article] BTB and CNC homolog 1 (Bach1) deficiency ameliorates TNBS colitis in mice: role of M2 macrophages and heme oxygenase-12013

    • Author(s)
      Harusato A, Naito Y, Takagi T, Uchiyama K, Mizushima K, Hirai Y, Higashimura Y, Katada K, Handa O, Ishikawa T, Yagi N, Kokura S, Ichikawa H, Muto A, Igarashi K, Yoshikawa T
    • Journal Title

      Inflamm Bowel Dis

      Volume: 19 Pages: 740-53

    • Peer Reviewed
  • [Journal Article] Role of metallothionein in murine experimental colitis2013

    • Author(s)
      Tsuji T, Naito Y, Takagi T, Kugai M, Yoriki H, Horie R, Fukui A, Mizushima K, Hirai Y, Katada K, Kamada K, Uchiyama K, Handa O, Konishi H, Yagi N, Ichikawa H, Yanagisawa R, Suzuki JS, Takano H, Satoh M, Yoshikawa T
    • Journal Title

      Int J Mol Med

      Volume: 31 Pages: 1037-46

    • Peer Reviewed
  • [Journal Article] Hemin ameliorates indomethacin-induced small intestinal injury in mice through the induction of heme oxygenase-12013

    • Author(s)
      Yoriki H, Naito Y, Takagi T, Mizusima K, Hirai Y, Harusato A, Yamada S, Tsuji T, Kugai M, Fukui A, Higashimura Y, Katada K, Kamada K, Uchiyama K, Handa O, Yagi N, Ichikawa H, Yosikawa T
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 28 Pages: 632-8

    • Peer Reviewed
  • [Journal Article] Exercise-induced muscle damage impairs insulin signaling pathway associated with IRS-1 oxidative modification2012

    • Author(s)
      Aoi W, Naito Y, Tokuda H, Tanimura Y, Oya-Ito T, Yoshikawa T
    • Journal Title

      Physiol Res

      Volume: 61 Pages: 91-8

    • Peer Reviewed
  • [Journal Article] Acetyl salicylic acid induces damage to intestinal epithelial cells by oxidation-related modifications of ZO-12012

    • Author(s)
      Fukui A, Naito Y, Handa O, Kugai M, Tsuji T, Yoriki H, Qin Y, Adachi S, Higashimura Y, Mizushima K, Kamada K, Katada K, Uchiyama K, Ishikawa T, Takagi T, Yagi N, Kokura S, Yoshikawa T
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol

      Volume: 303 Pages: G927-36

    • Peer Reviewed
  • [Journal Article] Oligosaccharides from agar inhibit murine intestinal inflammation through the induction of heme oxygenase-1 expression2012

    • Author(s)
      Higashimura Y, Naito Y, Takagi T, Mizushima K, Hirai Y, Harusato A, Ohnogi H, Yamaji R, Inui H, Nakano Y, Yoshikawa T
    • Journal Title

      J Gastroenterol

    • Peer Reviewed
  • [Journal Article] A questionnaire-based survey on screening for gastric and colorectal cancer by physicians in East Asian countries in 20102012

    • Author(s)
      Naito Y, Uchiyama K, Kinoshita Y, Fukudo S, Joh T, Suzuki H, Takahashi S, Ueno F, Fujiwara Y, Arakawa T, Matsumoto T, Hahm KB, Kachintorn U, Syam AF, Rani AA, Sollano JD, Zhu Q
    • Journal Title

      Digestion

      Volume: 86 Pages: 94-106

    • Peer Reviewed
  • [Journal Article] Naito Y, Uchiyama K, Takagi T, Yoshikawa T2012

    • Author(s)
      Naito Y, Uchiyama K, Takagi T, Yoshikawa T
    • Journal Title

      Curr Med Chem

      Volume: 19 Pages: 70-6

    • Peer Reviewed
  • [Journal Article] Detection of N-(hexanoyl)lysine in the tropomyosin 1 protein in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat gastric cancer cells2012

    • Author(s)
      Okada H, Naito Y, Takagi T, Takaoka M, Oya-Ito T, Fukumoto K, Uchiyama K, Handa O, Kokura S, Nagano Y, Matsui H, Kato Y, Osawa T, Yoshikawa T
    • Journal Title

      J Clin Biochem Nutr

      Volume: 50 Pages: 47-52

    • Peer Reviewed
  • [Journal Article] Hemopexin is upregulated in rat intestinal mucosa injured by indomethacin2012

    • Author(s)
      Takagi T, Naito Y, Okada H, Takaoka M, Oya-Ito T, Yamada S, Hirai Y, Mizushima K, Yoshida N, Kamada K, Katada K, Uchiyama K, Ishikawa T, Handa O, Yagi N, Konishi H, Kokura S, Ichikawa H, Yoshikawa T
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 27 Suppl 3 Pages: 70-5

    • Peer Reviewed
  • [Journal Article] The role of methylglyoxal-modified proteins in gastric ulcer healing2012

    • Author(s)
      Takagi T, Naito Y, Oya-Ito T, Yoshikawa T
    • Journal Title

      The role of methylglyoxal-modified proteins in gastric ulcer healing

      Volume: 19 Pages: 137-44

    • Peer Reviewed
  • [Journal Article] Colonic insufflation with carbon monoxide gas inhibits the development of intestinal inflammation in rats2012

    • Author(s)
      Takagi T, Naito Y, Uchiyama K, Okuda T, Suzuki T, Tsuboi H, Mizushima K, Handa O, Yagi N, Ichikawa H, Yoshikawa T
    • Journal Title

      Med Gas Res

      Volume: 2 Pages: 23

    • Peer Reviewed
  • [Journal Article] Serpin B1 protects colonic epithelial cell via blockage of neutrophil elastase activity and its expression is enhanced in patients with ulcerative colitis2012

    • Author(s)
      Uchiyama K, Naito Y, Takagi T, Mizushima K, Hirai Y, Hayashi N, Harusato A, Inoue K, Fukumoto K, Yamada S, Handa O, Ishikawa T, Yagi N, Kokura S, Yoshikawa T
    • Journal Title

      Am J PhysiolGastrointest Liver Physiol in press

    • Peer Reviewed
  • [Journal Article] Clinical studies of molecular targeted therapies for inflammatory bowel disease2012

    • Author(s)
      Uchiyama K, Takagi T, Naito Y
    • Journal Title

      Translational Medicine On line

      Volume: 2161-1025-S2-004

    • Peer Reviewed
  • [Journal Article] Rebamipide ameliorates indomethacin-induced small intestinal injury in rats via the inhibition of matrix metalloproteinases activity2012

    • Author(s)
      Yamada S, Naito Y, Takagi T, Mizushima K, Horie R, Fukumoto K, Inoue K, Harusato A, Uchiyama K, Handa O, Yagi N, Ichikawa H, Yoshikawa T
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 27 Pages: 1816-24

    • Peer Reviewed
  • [Journal Article] Partially hydrolyzed guar gum affects the expression of genes involved in host defense functions and cholesterol absorption in colonic mucosa of db/db male mice2012

    • Author(s)
      J Gastroenterol Hepatol
    • Journal Title

      J Clin Biochem Nutr

      Volume: 51 Pages: 33-8

    • Peer Reviewed
  • [Journal Article] Yoshida N, Naito Y, Inada Y, Kugai M, Inoue K, Uchiyama K, Handa O, Takagi T,Konishi H, Yagi N, Morimoto Y, Wakabayashi N, Yanagisawa A, Yoshikawa T2012

    • Author(s)
      Yoshida N, Naito Y, Inada Y, Kugai M, Inoue K, Uchiyama K, Handa O, Takagi T,Konishi H, Yagi N, Morimoto Y, Wakabayashi N, Yanagisawa A, Yoshikawa T
    • Journal Title

      Int J Colorectal Dis

      Volume: 27 Pages: 605-11

    • Peer Reviewed
  • [Journal Article] Endoscopic mucosal resection with 0.13% hyaluronic acid solution for colorectal polyps less than 20 mm: A randomized controlled trial2012

    • Author(s)
      Yoshida N, Naito Y, Inada Y, Kugai M, Kamada K, Katada K, Uchiyama K, Ishikawa T, Takagi T, Handa O, Konishi H, Yagi N, Kokura S, Wakabayashi N, Yanagisawa A, Yoshikawa T
    • Journal Title

      J Gastroenterol Hepatol

    • Peer Reviewed
  • [Journal Article] Multicenter study of endoscopic mucosal resection using 0.13 % hyaluronic acid solution of colorectal polyps less than 20 mm in siz2012

    • Author(s)
      Yoshida N, Naito Y, Inada Y, Kugai M, Yagi N, Inoue K, Okuda T, Hasegawa D, Kanemasa K, Kyoichi K, Matsuyama K,Ando T, Takemura T, Shimizu S, Wakabayashi N, Yanagisawa A, Yoshikawa T
    • Journal Title

      Int J Colorectal Dis

    • Peer Reviewed
  • [Journal Article] Importance of histological evaluation in endoscopic resection of early colorectal cancer2012

    • Author(s)
      Yoshida N, Naito Y, Yagi N, Yanagisawa A
    • Journal Title

      World J Gastrointest Pathophysiol

      Volume: 3 Pages: 51-9

    • Peer Reviewed
  • [Journal Article] Regular exercise prevents high-sucrose diet-induced fatty liver via improvement of hepatic lipid metabolism2011

    • Author(s)
      Aoi W, Naito Y, Hang LP, Uchiyama K, Akagiri S, Mizushima K, Yoshikawa T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 413 Pages: 330-5

    • Peer Reviewed
  • [Journal Article] Dietary exercise as a novel strategy for the prevention and treatment of metabolic syndrome: effects on skeletal muscle function2011

    • Author(s)
      Aoi W, Naito Y, Yoshikawa T
    • Journal Title

      J Nutr Metab

      Volume: 2011 Pages: 676208

    • Peer Reviewed
  • [Journal Article] Dietary whey hydrolysate with exercise alters the plasma protein profile: a comprehensive protein analysis2011

    • Author(s)
      Aoi W, Takanami Y, Kawai Y, Morifuji M, Koga J, Kanegae M, Mihara K, Yanohara T, Mukai J, Naito Y, Yoshikawa T
    • Journal Title

      Nutrition

      Volume: 27 Pages: 687-92

    • Peer Reviewed
  • [Journal Article] Suppression of indomethacin-induced apoptosis in the small intestine due to Bach1 deficiency2011

    • Author(s)
      Harusato A, Naito Y, Takagi T, Uchiyama K, Mizushima K, Hirai Y, Yamada S, Tuji T, Yoriki H, Horie R, Inoue K, Fukumoto K, Handa O, Ishikawa T, Kokura S, Minamiyama Y, Ichikawa H, Muto A, Igarashi K, Yoshikawa T
    • Journal Title

      Free Radic Res

      Volume: 45 Pages: 717-27

    • Peer Reviewed
  • [Journal Article] Endogenous hydrogen sulfide is an anti-inflammatory molecule in dextran sodium sulfate-induced colitis in mice2011

    • Author(s)
      Hirata I, Naito Y, Takagi T, Mizushima K, Suzuki T, Omatsu T, Handa O, Ichikawa H, Ueda H, Yoshikawa T
    • Journal Title

      Dig Dis Sci

      Volume: 56 Pages: 1379-86

    • Peer Reviewed
  • [Journal Article] Daikenchuto, a kampo medicine, regulates intestinal fibrosis associated with decreasing expression of heat shock protein 47 and collagen content in a rat colitis model2011

    • Author(s)
      Inoue K, Naito Y, Takagi T, Hayashi N, Hirai Y, Mizushima K, Horie R, Fukumoto K, Yamada S, Harusato A, Hirata I, Omatsu T, Yoshida N, Uchiyama K, Ishikawa T, Handa O, Konishi H, Wakabayashi N, Yagi N, Ichikawa H, Kokura S, Yoshikawa T
    • Journal Title

      Biol Pharm Bull

      Volume: 34 Pages: 1659-65

    • Peer Reviewed
  • [Journal Article] Oxidative stress-induced posttranslational modification of TRPV1 expressed in esophageal epithelial cells2011

    • Author(s)
      Kishimoto E, Naito Y, Handa O, Okada H, Mizushima K, Hirai Y, Nakabe N, Uchiyama K, Ishikawa T, Takagi T, Yagi N, Kokura S, Yoshida N, Yoshikawa T
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol

      Volume: 301 Pages: G230-8

    • Peer Reviewed
  • [Journal Article] Gastric peroxisome proliferator activator receptor-gamma expression and cytoprotective actions of its ligands against ischemia-reperfusion injury in rats2011

    • Author(s)
      Naito Y, Takagi T, Katada K, Tomatsuri N, Mizushima K, Handa O, Kokura S, Yagi N, Ichikawa H, Yoshikawa T
    • Journal Title

      J Clin Biochem Nutr

      Volume: 48 Pages: 170-7

    • Peer Reviewed
  • [Journal Article] Heme oxygenase-1: a novel therapeutic target for gastrointestinal diseases2011

    • Author(s)
      Naito Y, Takagi T, Uchiyama K, Yoshikawa T
    • Journal Title

      J Clin Biochem Nutr

      Volume: 48 Pages: 126-33

    • Peer Reviewed
  • [Journal Article] Heat-shock protein 27 (Hsp27) as a target of methylglyoxal in gastrointestinal cancer2011

    • Author(s)
      Oya-Ito T, Naito Y, Takagi T, Handa O, Matsui H, Yamada M, Shima K, Yoshikawa T
    • Journal Title

      Biochim Biophys Acta

      Volume: 1812 Pages: 769-81

    • Peer Reviewed
  • [Journal Article] Heat shock protein 70-dependent protective effect of polaprezinc on acetylsalicylic acid-induced apoptosis of rat intestinal epithelial cells2011

    • Author(s)
      Qin Y, Naito Y, Handa O, Hayashi N, Kuki A, Mizushima K, Omatsu T, Tanimura Y, Morita M, Adachi S, Fukui A, Hirata I, Kishimoto E, Nishikawa T, Uchiyama K, Ishikawa T, Takagi T, Yagi N, Kokura S, Yoshikawa T
    • Journal Title

      J Clin Biochem Nutr

      Volume: 49 Pages: 174-81

    • Peer Reviewed
  • [Journal Article] Identification of dihalogenated proteins in rat intestinal mucosa injured by indomethacin2011

    • Author(s)
      Takagi T, Naito Y, Okada H, Okayama T, Mizushima K, Yamada S, Fukumoto K, Inoue K, Takaoka M, Oya-Ito T, Uchiyama K, Ishikawa T, Handa O, Kokura S, Yagi N, Ichikawa H, Kato Y, Osawa T, Yoshikawa T.
    • Journal Title

      J Clin Biochem Nutr

      Volume: 48 Pages: 178-82

    • Peer Reviewed
  • [Journal Article] Rebamipide promotes healing of colonic ulceration through enhanced epithelial restitution2011

    • Author(s)
      Takagi T, Naito Y, Uchiyama K, Okuda T, Mizushima K, Suzuki T, Handa O, Ishikawa T, Yagi N, Kokura S, Ichikawa H, Yoshikawa T
    • Journal Title

      World J Gastroenterol

      Volume: 17 Pages: 3802-9

    • Peer Reviewed
  • [Journal Article] Carbon monoxide liberated from carbon monoxide-releasing molecule exerts an anti-inflammatory effect on dextran sulfate sodium-induced colitis in mice2011

    • Author(s)
      Takagi T, Naito Y, Uchiyama K, Suzuki T, Hirata I, Mizushima K, Tsuboi H, Hayashi N, Handa O, Ishikawa T, Yagi N, Kokura S, Ichikawa H, Yoshikawa T
    • Journal Title

      Dig Dis Sci

      Volume: 56 Pages: 1663-71

    • Peer Reviewed
  • [Journal Article] Multifaceted Assessment of Chronic Gastritis: A Study of Correlations between Serological, Endoscopic, and Histological Diagnostics2011

    • Author(s)
      Takao T, Ishikawa T, Ando T, Takao M, Matsumoto T, Isozaki Y, Okita M, Nagao Y, Oyamada H, Yokoyama K, Tatebe A, Uchiyama K, Handa O, Takagi T, Yagi N, Kokura S, Naito Y, Yoshikawa T
    • Journal Title

      astroenterol Res Pract

      Volume: 2011 Pages: 6314

    • Peer Reviewed
  • [Journal Article] FGF19 protects colonic epithelial cells against hydrogen peroxide2011

    • Author(s)
      Uchiyama K, Naito Y, Takagi T, Mizushima K, Hayashi N, Handa O, Ishikawa T, Yagi N, Kokura S, Yoshikawa T
    • Journal Title

      Digestion

      Volume: 83 Pages: 180-3

    • Peer Reviewed
  • [Journal Article] Reduced small-intestinal injury induced by indomethacin in interleukin-17A-deficient mice2011

    • Author(s)
      Yamada S, Naito Y, Takagi T, Mizushima K, Hirai Y, Horie R, Fukumoto K, Inoue K, Harusato A, Yoshida N, Uchiyama K, Handa O, Ishikawa T, Konishi H, Wakabayashi N, Yagi N, Kokura S, Kita M, Yoshikawa T
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 26 Pages: 398-404

    • Peer Reviewed
  • [Journal Article] Efficacy of magnifying endoscopy with flexible spectral imaging color enhancement in the diagnosis of colorectal tumors2011

    • Author(s)
      Yoshida N, Naito Y, Kugai M, Inoue K, Uchiyama K, Takagi T, Ishikawa T, Handa O, Konishi H, Wakabayashi N, Kokura S, Yagi N, Morimoto Y, Yanagisawa A, Yoshikawa T.
    • Journal Title

      J Gastroenterol

      Volume: 46 Pages: 65-72

    • Peer Reviewed
  • [Journal Article] Efficacy of hyaluronic acid in endoscopic mucosal resection of colorectal tumors2011

    • Author(s)
      Yoshida N, Naito Y, Kugai M, Inoue K, Uchiyama K, Takagi T, Ishikawa T, Handa O, Konishi H, Wakabayashi N, Yagi N, Kokura S, Morimoto Y, Kanemasa K, Yanagisawa A, Yoshikawa T
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 26 Pages: 286-91

    • Peer Reviewed
  • [Journal Article] The microRNA miR-696 regulates PGC-1{alpha} in mouse skeletal muscle in response to physical activity2010

    • Author(s)
      Aoi W, Naito Y, Mizushima K, Takanami Y, Kawai Y, Ichikawa H, Yoshikawa T
    • Journal Title

      Am J Physiol Endocrinol Metab

      Volume: 298 Pages: E799-806

    • Peer Reviewed
  • [Journal Article] Regular exercise reduces colon tumorigenesis associated with suppression of iNOS2010

    • Author(s)
      Aoi W, Naito Y, Takagi T, Kokura S, Mizushima K, Takanami Y, Kawai Y,Tanimura Y, Hung LP, Koyama R, Ichikawa H, Yoshikawa T.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 399 Pages: 14-19

    • Peer Reviewed
  • [Journal Article] Chemical and immunochemical detection of 8-halogenated deoxyguanosines at early stage inflammation2010

    • Author(s)
      Asahi T, Kondo H, Masuda M, Nishino H, Aratani Y, Naito Y, Yoshikawa T, Hisaka S, Kato Y, Osawa T
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 9282-91

    • Peer Reviewed
  • [Journal Article] Identification of inflammation-related proteins in a murine colitis model by 2D fluorescence difference gel electrophoresis and mass spectrometry2010

    • Author(s)
      Naito Y, Takagi T, Okada H, Omatsu T, Mizushima K, Handa O, Kokura S, Ichikawa H, Fujiwake H, Yoshikawa T
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 25 Suppl 1 Pages: S144-8

    • Peer Reviewed
  • [Journal Article] Lansoprazole, a proton pump inhibitor, to reduce gastrointestinal inflammation via heme oxygenase-1 induction2010

    • Author(s)
      Naito Y, Takagi T, Yoshikawa T
    • Journal Title

      Molecular Cellular Pharmacol

      Volume: 2 Pages: 53-60

    • Peer Reviewed
  • [Journal Article] Rebamipide: a gastrointestinal protective drug with pleiotropic activities2010

    • Author(s)
      Naito Y, Yoshikawa T
    • Journal Title

      Expert Rev Gastroenterol Hepatol

      Volume: 4 Pages: 261-70

    • Peer Reviewed
  • [Journal Article] Reactive oxygen species-quenching and anti-apoptotic effect of polaprezinc on indomethacin-induced small intestinal epithelial cell injury2010

    • Author(s)
      Omatsu T, Naito Y, Handa O, Mizushima K, Hayashi N, Qin Y, Harusato A, Hirata I, Kishimoto E, Okada H, Uchiyama K, Ishikawa T, Takagi T, Yagi N, Kokura S, Ichikawa H, Yoshikawa T
    • Journal Title

      J Gastroenterol

      Volume: 45 Pages: 692-702

    • Peer Reviewed
  • [Journal Article] Increased expression of microRNA in the inflamed colonic mucosa of patients with active ulcerative colitis2010

    • Author(s)
      Takagi T, Naito Y, Mizushima K, Hirata I, Yagi N, Tomatsuri N, Ando T, Oyamada Y,Isozaki Y, Hongo H, Uchiyama K, Handa O, Kokura S, Ichikawa H, Yoshikawa T
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 25 Suppl 1 Pages: S129-33

    • Peer Reviewed
  • [Journal Article] Ecabet sodium promotes the healing of trinitrobenzene-sulfonic-acid-induced ulceration by enhanced restitution of intestinal epithelial cells2010

    • Author(s)
      Takagi T, Naito Y, Okuda T, Uchiyama K, Adachi S, Mizushima K, Handa O, Kokura S, Ichikawa H, Yoshikawa T
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 25 Pages: 1259-65

    • Peer Reviewed
  • [Journal Article] The role of heme oxygenase and carbon monoxide in inflammatory bowel disease2010

    • Author(s)
      Takagi T, Naito Y, Uchiyama K, Yoshikawa T
    • Journal Title

      Redox Rep

      Volume: 15 Pages: 193-201

    • Peer Reviewed
  • [Journal Article] Carbon monoxide enhance colonic epithelial restitution via FGF15 derived from colonic myofibroblasts2010

    • Author(s)
      Uchiyama K, Naito Y, Takagi T, Mizushima K, Hayashi N, Harusato A, Hirata I, Omatsu T, Handa O, Ishikawa T, Yagi N, Kokura S, Yoshikawa T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 391 Pages: 1122-1126

    • Peer Reviewed
  • [Journal Article] Gastrointestinal cytoprotection by PPAR・ligands

    • Author(s)
      Naito Y, Takagi T, Yoshikawa T
    • Journal Title

      PPAR Research

    • DOI

      doi:10.1155/2010/108632,2010

    • Peer Reviewed
  • [Presentation] ベーシックサイエンスシンポジウム「細胞ストレスと代謝応答:生活習慣病への取り組み」消化管における酸化ストレス応答と Peroxiredoxin-62012

    • Author(s)
      内藤裕二, 高木智久,伊藤(大矢)友子,吉川敏一
    • Organizer
      第12回日本抗加齢医学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2012-06-23
  • [Presentation] シンポジウム「老い木に花咲く~見た目の老化に対する内的制御」消化管は全身の司令塔~Mirobiome から GLP-1 まで~2012

    • Author(s)
      内藤裕二,吉川敏一
    • Organizer
      第12回日本抗加齢医学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2012-06-22
  • [Presentation] ミニシンポジウム「Neutraceutical をめぐって」消化管炎症抑制ヘムオキシゲナーゼを標的にした機能性食品成分2012

    • Author(s)
      内藤裕二, 高木智久,吉川敏一
    • Organizer
      第98回日本消化器病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-19
  • [Presentation] シンポジウム「酸化ストレス研究-新しいバイオマーカーを求めて」消化管粘膜における Peroxiredoxin-6 の役割2012

    • Author(s)
      内藤裕二、 高木智久、吉川敏一
    • Organizer
      第82回日本衛生学会学術総会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-25
  • [Presentation] シンポジウム「何をどう食べるかの科学」運動と食品因子による大腸癌予防2011

    • Author(s)
      内藤裕二,青井 渉,吉川敏一
    • Organizer
      第11回日本抗加齢医学会総会
    • Place of Presentation
      京都
    • Year and Date
      2011-05-27
  • [Presentation] シンポジウム「消化器疾患と微小循環・酸化ストレス」翻訳後修飾タンパク質の解析で見えてきた酸化ストレス研究の新展開2011

    • Author(s)
      内藤裕二, 高木智久,吉川敏一
    • Organizer
      第97回日本消化器病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-13
  • [Presentation] シンポジウム「酸化ストレス研究-臨床から基礎まで」翻訳後修飾タンパク質の解析で見えてきた酸化ストレス研究の新展開2011

    • Author(s)
      内藤裕二, 高木智久,吉川敏一
    • Organizer
      第81回日本衛生医学会
    • Place of Presentation
      東京(東日本大震災のため誌上発表)
    • Year and Date
      2011-03-27
  • [Presentation] ネルディスカッション「大腸がん研究の新たな展開と治療戦略」運動による大腸腫瘍抑制作用は Secreted protein acidic and rich cystein(SPARC)を介する2010

    • Author(s)
      内藤裕二, 高木智久,吉川敏一
    • Organizer
      第80回日本消化器内視鏡 学会総会(JDDW2010)
    • Place of Presentation
      横浜
    • Year and Date
      2010-10-15
  • [Presentation] ワークショップ「薬剤性小腸病変を巡って-現状と対策」OGIB 症例における服薬内容と小腸内視鏡所見の検討2010

    • Author(s)
      内藤裕二,半田 修,若林直樹
    • Organizer
      80回日本消化器内視鏡学会総会(JDDW2010)
    • Place of Presentation
      横浜
    • Year and Date
      2010-10-15
  • [Presentation] シンポジウム「抗酸化食品因子の新規な機能探索とその応用」蛋白質の酸化特異的修飾解析による機能性食品有効性評価標的分子の探索2010

    • Author(s)
      内藤裕二,半田 修,青井 渉,高橋二郎,吉川敏一
    • Organizer
      第63回日本酸化ストレス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2010-06-25
  • [Remarks]

    • URL

      http://www.f.kpu-m.ac.jp/k/sun/

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Published: 2014-08-29  

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