2012 Fiscal Year Final Research Report
Development of immunotherapy for hepatocellular carcinoma by peptide vaccine
| Project/Area Number |
22590723
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | ELISPOTアッセイ / ヘルパーT細胞 / ペプチド / ワクチン / 免疫治療 / 肝細胞癌 |
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| Research Abstract |
In the present study, we tried to develop immunotherapy for hepatocellular carcinoma (HCC) by peptide vaccine. The following results were obtained from this study. 1) The helper T cell (HTL) epitopes in AFP and hTERT were identified. 2) Immune responses against these HTL epitopes in peripheral blood mononuclear cells of HCC patients were observed. 3) Peptide vaccines encoding amino acid sequences in the HTL epitopes were developed based on the above results.
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