• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2012 Fiscal Year Final Research Report

Comprehensive analysis of the relationship between gene polymorphisms and protein expression and pathology, therapeutic value and prognosis of autoimmune liver diseases.

Research Project

  • PDF
Project/Area Number 22590725
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionShinshu University

Principal Investigator

YOSHIZAWA Kaname  信州大学, 医学部, 特任教授 (90220615)

Co-Investigator(Kenkyū-buntansha) OTA Masao  信州大学, 医学部, 准教授 (50115333)
UMRMURA Takeji  信州大学, 医学部, 准教授 (30419345)
Project Period (FY) 2010 – 2012
Keywords自己免疫性肝炎 / 原発性胆汁性肝硬変 / 疾患感受性遺伝子 / 遺伝子多型 / ゲノムワイド解析 / サイトカイン
Research Abstract

The outcome of autoimmune hepatitis (AIH) over a long follow-up period compared with that of the general Japanese population as well as that among patients. Repeated relapses of AIH are significantly associated with a poorer long-term prognosis. AIH patients can expect a similar prognosis to that of the general population, provided that they are adequately managed with continuous low doses of immunosuppressive therapy, especially after the first relapse. A complex interplay of several cytokines, especially pro-inflammatory and Th17 cytokines and regulatory T cell suppression by IL-12p40 may play a pivotal role in the pathogenesis of AIH. The roles of HLA haplotypes and several gene polymorphisms in determining primary biliary cirrhosis susceptibility and progression were clarified by SNP analysis including genome -wide association study.

  • Research Products

    (30 results)

All 2013 2012 2011 2010

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (17 results) Book (1 results)

  • [Journal Article] Association analysis of toll-like receptor 4 polymorphisms in Japanese primary biliary cirrhosis.2013

    • Author(s)
      Morita S, Joshita S, Umemura T, Katsuyama Y, Kimura T, Komatsu M, Matsumoto A, Yoshizawa K, Kamijo A, Yamamura N, Tanaka E, Ota M.
    • Journal Title

      Hum Immunol.

      Volume: 74 Pages: 219-22

    • Peer Reviewed
  • [Journal Article] Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population2012

    • Author(s)
      Nakamura M, Nishida N, Kawashima M, Aiba Y, Tanaka A, Yasunami M, Nakamura H, Komori A, Nakamuta M, Zeniya M, Hashimoto E, Ohira H, Yamamoto K, Onji M, Kaneko S, Honda M, Yamagiwa S, Nakao K, Ichida T, Takikawa H, Seike M, Umemura T, Ueno Y, Sakisaka S, Kikuchi K, Ebinuma H, Yamashiki N, Tamura S, Sugawara Y, Mori A, Yagi S, Shirabe K, Taketomi A, Arai K, Monoe K, Ichikawa T, Taniai M, Miyake Y, Kumagi T, Abe M, Yoshizawa K, Joshita S, Shimoda S, Honda K, Takahashi H, Hirano K, Takeyama Y, Harada K, Migita K, Ito M, Yatsuhashi H, Fukushima N, Ota H, Komatsu T, Saoshiro T, Ishida J, Kouno H, Kouno H, Yagura M, Kobayashi M, Muro T, Masaki N, Hirata K, Watanabe Y, Nakamura Y, Shimada M, Hirashima N, Komeda T, Sugi K, Koga M, Ario K, Takesaki E, Maehara Y, Uemoto S, Kokudo N, Tsubouchi H, Mizokami M, Nakanuma Y, Tokunaga K, Ishibashi H.
    • Journal Title

      Am J Hum Genet.

      Volume: 91 Pages: 721-8

    • Peer Reviewed
  • [Journal Article] Long-term outcome of Japanese patients with type 1 autoimmune hepatitis.2012

    • Author(s)
      Yoshizawa K, Matsumoto A, Ichijo T, Umemura T, Joshita S, Komatsu M, Tanaka N, Tanaka E, Ota M, Katsuyama Y, Kiyosawa K, Abe M, Onji M.
    • Journal Title

      Hepatology.

      Volume: 56 Pages: 66876

    • Peer Reviewed
  • [Journal Article] Human leukocyte antigen class II molecules confer both susceptibility and progression in Japanese patients with primary biliary cirrhosis.2012

    • Author(s)
      Umemura T, Joshita S, Ichijo T, Yoshizawa K, Katsuyama Y, Tanaka E, Ota M; Shinshu PBC Study Group.
    • Journal Title

      Hepatology.

      Volume: 55 Pages: 506-11

    • Peer Reviewed
  • [Journal Article] Primary biliary cirrhosis - Autoimmune hepatitis overlap syndrome: A rationale for corticosteroids use based on a nation-wide retrospective study in Japan.2011

    • Author(s)
      Tanaka A, Harada K, Ebinuma H, Komori A, Yokokawa J, Yoshizawa K, Abe M, Miyake Y, Kikuchi K, Ohira H, Zeniya M, Yamamoto K, Ishibashi H, Onji M, Nakanuma Y, Tsubouchi H, Takikawa H
    • Journal Title

      Hepatol Res.

      Volume: 41 Pages: 877-886

    • Peer Reviewed
  • [Journal Article] Polymorphism in the KCNA3 gene is associated with susceptibility to autoimmune pancreatitis in the Japanese population.2011

    • Author(s)
      Ota M, Ito T, Umemura T, Katsuyama Y, Yoshizawa K, Hamano H, Kawa S.
    • Journal Title

      Dis Markers.

      Volume: 31 Pages: 223-9

    • Peer Reviewed
  • [Journal Article] Genetic polymorphisms in CTLA4 and SLC4A2 are differentially associated with the pathogenesis of primary biliary cirrhosis in Japanese patients.2011

    • Author(s)
      Aiba Y, Nakamura M, Joshita S, Inamine T, Komori A, Yoshizawa K, Umemura T, Horie H, Migita K, Yatsuhashi H, Nakamuta M, Fukushima N, Saoshiro T, Hayashi S, Kouno H, Ota H, Muro T, Watanabe Y, Nakamura Y, Komeda T, Shimada M, Masaki N, Komatsu T, Yagura M, Sugi K, Koga M, Tsukamoto K, Tanaka E, Ishibashi H
    • Journal Title

      J Gastroenterol.

      Volume: 46 Pages: 1203-12

    • Peer Reviewed
  • [Journal Article] Cytokine profiles affecting the pathogenesis of autoimmune hepatitis in Japanese patients.2011

    • Author(s)
      Kamijo A, Yoshizawa K, Joshita S, Yoneda S, Umemura T, Ichijo T, Matsumoto A, Ota M, Tanaka E.
    • Journal Title

      Hepatol Res.

      Volume: 41 Pages: 350-7

    • Peer Reviewed
  • [Journal Article] Clinical significance of immunoglobulin G4-associated autoimmune hepatitis.2011

    • Author(s)
      Umemura T, Zen Y, Hamano H, Joshita S, Ichijo T, Yoshizawa K, Kiyosawa K, Ota M, Kawa S, Nakanuma Y, Tanaka E.
    • Journal Title

      J Gastroenterol.

      Volume: 46 Pages: 48-55

    • Peer Reviewed
  • [Journal Article] Genetic background of autoimmune hepatitis in Japan.2011

    • Author(s)
      Yoshizawa K, Umemura T, Ota M.
    • Journal Title

      J Gastroenterol.

      Volume: 46 Suppl 1 Pages: 42-7

    • Peer Reviewed
  • [Journal Article] A2BP1 as a novel susceptible gene for primary biliary cirrhosis in Japanese patients.2010

    • Author(s)
      Joshita S, Umemura T, Yoshizawa K,Katsuyama Y, Tanaka E, Ota M; Shinshu PBC Study Group.
    • Journal Title

      Hum Immuno l

      Volume: 71 Pages: 520-524

    • Peer Reviewed
  • [Journal Article] Association analysis of cytotoxic T -lymphocyte antigen 4 gene polymorphisms with primary biliary cirrhosis in Japanese patients.2010

    • Author(s)
      Joshita S, Umemura T, Yoshizawa K, Katsuyama Y, Tanaka E, Nakamura M, Ishibashi H, Ota M; The Shinshu PBC Study Group.
    • Journal Title

      J Hepatol.

      Volume: 53 Pages: 537-541

    • Peer Reviewed
  • [Presentation] Signal transducer and activator of transcription 4 gene polymorphisms are associated with production of anti-nuclear antibody in Japanese patients with primary biliary cirrhosis.2012

    • Author(s)
      Joshita S, Umemura T, Nakamura M, Yoshizawa K, Katsuyama Y, Shibata S, Okuhara S, Nozawa Y , Kimura T, Morita S, Komatsu M, Matsumoto A, Tanaka E, Ota M.
    • Organizer
      アメリカ肝臓学 会 AASLD 2012
    • Place of Presentation
      Boston, USA
    • Year and Date
      2012-11-02
  • [Presentation] HLA DRB1*09:01-DQB1*03:03 Haplotype is associated with progression of Primary Biliary Cirrhosis.2012

    • Author(s)
      Umemura T, Joshita S, Katsuyama Y, Shibata S, Kimura T, Morita S, Komatsu M, Matsumoto A, Yoshizawa K, Tanaka E, Ota M
    • Organizer
      ア メリ カ肝臓学 会AASLD 2012
    • Place of Presentation
      Boston, USA
    • Year and Date
      2012-11-02
  • [Presentation] 日本人原発性胆汁性肝硬変の病態形成に関与する HLA-A, -B, -DP, -DR 遺伝子多型と CTLA-4, SLC4A2, IL12A2012

    • Author(s)
      相葉 佳洋、安波道郎、小森敦正、右田清志、八橋 弘、中牟田誠、福嶋伸良、太田 肇、石田仁也、平田啓一、渡部幸夫、小松達司、矢倉道泰、高野弘嗣、室豊吉、島田昌明、米田俊貴、山下晴弘、竹崎英一、古賀満明、小林正和、杉 和洋、正木尚彦、吉澤 要、蒔田富士雄、高木 均、西村英夫、石橋大海、中村 稔
    • Organizer
      IRF5 遺伝子多型の検討 第48回日本肝臓学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2012-06-07
  • [Presentation] 日本人原発性胆汁性肝硬変のゲノムワイド解析2012

    • Author(s)
      中村 稔、西田奈央、川嶋実苗、田中 篤、中牟田誠、太田 肇、竿代丈夫、高野弘嗣、吉澤 要、小森敦正、梅村武司、銭谷幹男、恩地森一、橋本悦子、大平弘正、山本和秀、金子周一、山際 訓、中尾一彦、市田隆文、滝川 一、前原喜彦、上本伸一、国土典宏、坪内博仁、溝上雅史、徳永勝士、中沼安二、石橋大海
    • Organizer
      第48回日本肝臓学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2012-06-07
  • [Presentation] 自己免疫性肝炎の長期予後2012

    • Author(s)
      吉澤 要、松本晶博、梅村武司、一條哲也、城下 智、小松通治、田中栄司、清澤研道、阿部雅則、恩地森一
    • Organizer
      第48回日本肝臓学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2012-06-07
  • [Presentation] Association analysis of signal transducer and activator of transcription 4 gene polymorphisms with primary billiary cirrhosis in Japanese patients.2011

    • Author(s)
      Joshita S, Umemura T, Yoshizawa K,Katsuyama Y , Okuhara S, Ichikawa Y , Kimura T , Morita M, Komatsu M, Ichijo T , Matsumoto A, Ota M, TanakaE.
    • Organizer
      アメリカ肝臓学会AASLD 2011
    • Place of Presentation
      San FranciscoUSA
    • Year and Date
      2011-11-08
  • [Presentation] 原発性胆汁性肝硬変における HLA の検討2011

    • Author(s)
      梅村武司、城下 智、 吉澤 要
    • Organizer
      JDDW 2011
    • Place of Presentation
      福岡
    • Year and Date
      2011-10-20
  • [Presentation] Association analysis of cytotoxic T -lymphocyte antigen 4 gene polymorphisms with primary billiary cirrhosis, autoimmune hepatitis, and overlap syndrome in Japanese patients.2011

    • Author(s)
      Joshita S, Umemura T, Nakamura M, Yoshizawa K, Ota M, Ishibashi H, Tanaka E
    • Organizer
      アジア太平洋消化器病週間 APDW
    • Place of Presentation
      Singapore
    • Year and Date
      2011-10-01
  • [Presentation] 長期経過からみた自己免疫性肝炎からの肝発癌2011

    • Author(s)
      吉澤 要、 松本晶博、一條哲也、城下智、木村岳史、市川雪、森田進、上條敦、小松通治、 梅村武司、田中榮司、 阿部雅則、恩地森一
    • Organizer
      第47回日本肝癌研究会
    • Place of Presentation
      静岡
    • Year and Date
      2011-07-28
  • [Presentation] 自己免疫性肝炎からの肝発癌の実態2010

    • Author(s)
      梅村武司、一條哲也、吉澤 要
    • Organizer
      第38回肝臓学会東部会
    • Place of Presentation
      東京
    • Year and Date
      2010-12-03
  • [Presentation] 自己免疫性肝炎におけるサイトカインの動向と病態との関連2010

    • Author(s)
      上條 敦、吉澤 要、城下 智、梅村武司、一條哲也、松本晶博、田中榮司
    • Organizer
      第38回肝臓学会東部会
    • Place of Presentation
      東京
    • Year and Date
      2010-12-03
  • [Presentation] Cytotoxic T -lymphocyte Antigen 4遺伝子多型と日本人の原発性胆汁性肝硬変発症に関する検討2010

    • Author(s)
      城下 智、 梅村武司、吉澤 要
    • Organizer
      第14回肝臓学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2010-10-14
  • [Presentation] 自己免疫性肝炎の長期予後に及ぼす因子2010

    • Author(s)
      吉澤 要、松本晶博、一條哲也、梅村武司、城下 智、小松通治、上條 敦、米田 傑、森田 進、松本晶博、 田中榮司、清澤研道
    • Organizer
      第46回肝臓学会総会
    • Place of Presentation
      山形
    • Year and Date
      2010-05-27
  • [Presentation] ataxin2-binding protein 1 遺伝子多型は原発性胆汁性肝硬変の疾患感受性と相関する2010

    • Author(s)
      城下 智、 梅村武司、吉澤 要、森田 進、米田 傑、上條 敦、小松通治、一條哲也、松本晶博、 田中榮司
    • Organizer
      第46回肝臓学会総会
    • Place of Presentation
      山形
    • Year and Date
      2010-05-27
  • [Presentation] Genetic background of autoimmune hepatitis in Japan.2010

    • Author(s)
      Yoshizawa K
    • Organizer
      日本消化器病学会 The 2ndInternational Forum
    • Place of Presentation
      Niigata
    • Year and Date
      2010-04-24
  • [Presentation] Clinical significance of immunoglobulin G4-associated autoimmune hepatitis.2010

    • Author(s)
      Umemura T.
    • Organizer
      日本消化器病学会 The 2ndInternational Forum
    • Place of Presentation
      Niigata
    • Year and Date
      2010-04-24
  • [Presentation] Ataxin 2-binding protein 1 as a novel susceptible gene for primary biliary cirrhosis in Japanese patients.2010

    • Author(s)
      Joshita S, Umemura T, Morita S, Kamijo A, Komatsu M, Ichijo T, Matsumoto A, Yoshizawa K, Tanaka E, Ota M.
    • Organizer
      ヨーロッパ肝臓学会 EASL
    • Place of Presentation
      Wien Austria
    • Year and Date
      2010-04-16
  • [Book] 肝疾患クリニカルスタンダード (自己免疫性肝炎他)2010

    • Author(s)
      吉澤 要 共著:編集 田中榮司他
    • Total Pages
      9-13, 71-77, 113-118, 127-130, 190-191
    • Publisher
      文光堂

URL: 

Published: 2014-08-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi