2012 Fiscal Year Final Research Report

To develop a new immune therapy for post liver transplantation hepatitis C.

Research Project

Project/Area Number	22590735
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Gastroenterology
Research Institution	Okayama University
Principal Investigator	TAKAKI Akinobu 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (80359885)
Co-Investigator(Kenkyū-buntansha)	YAGI Takahito 岡山大学, 岡山大学病院, 教授 (00304353) WATANABE Nobukazu 東京大学, 医科学研究所, 准教授 (10334278)
Project Period (FY)	2010 – 2012
Keywords	肝臓移植 / C型肝炎
Research Abstract	Immune regulation related molecule PD-L2 expression in the liver biopsy specimens and regulatory T cell frequency in peripheral blood were analyzed in post transplantation hepatitis C patients. The PD-L2 expression in the liver specimen was stronger in post-transplantation hepatitis C patients than other etiology. The regulatory T cell frequency was higher in severe hepatitis C recurrent patients. We found that these immune regulatory molecules could be the target to reduce post-transplantation severe hepatitis C recurrence.