Role of prostanoids in the bone marrow derived endothelial cells

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590765
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Asahikawa Medical College
• Principal Investigator: OKADA Motoi 旭川医科大学, 医学部, 講師 (80431427)
• Co-Investigator(Kenkyū-buntansha): KAWABE Junichi 旭川医科大学, 医学部, 特任准教授 (10400087)
• Co-Investigator(Renkei-kenkyūsha): YUHKI Kouiti 旭川医科大学, 医学部, 准教授 (80302420)
• Project Period (FY): 2010 – 2012
• Keywords: 臨床心血管病態学 / プロスタノイド

Research Abstract

We clarified the role of vascular prostanoids, i.e. prostacyclin and thromboxane in the bone marrow-derived endothelial cells (EPC). EPC expressed their specific receptor, IP and TP respectively. We observed the functional changed of EPCs derived from IP- or TP-deleted mice using injured femoral artery vascular remodeling and peripheral ischemic models. Finally we found that PGI2 and TXA2 strictly regulated the function of EPCs and contribute to the pathogenesis of vascular diseases.

Research Products

• [Journal Article] Prostacyclin stimulated integrin-dependent angiogenic effects of endothelial progenitor cells and mediated potent circulation recovery in ischemic hind limb model (2013)
  • Author(s): Aburakawa Y, Kawabe J, Okada M,Yamauchi A, Asanome A, Kabara M,Matsuki M, Takehara N, Nakagawa N,Okumura S, Minami Y, Mizukami Y, YuhkiK, Ushikubi F, Hasebe N
  • Journal Title: Circ J Volume: 77(4) Pages: 1053-1062
• [Journal Article] Roles of prostanoids in the pathogenesis of cardiovascular diseases: Novel insightsfrom knockout mouse studies (2011)
  • Author(s): Yuhki K,Kojima F, Kashiwagi H, Kawabe J, Fujino T
  • Journal Title: Narumiya S and Ushikubi F. PharmacoTherap Volume: 129 Pages: 195-205
• [Journal Article] Prostaglandin I2 promotes recruitment of endothelial progenitor cells and limits vascular remodeling (2010)
  • Author(s): Kawabe J, Yuhki KI,Okada M, Kanno T, Yamauchi A, Tashiro N,Sasaki T, Okumura S, Nakagawa N,Aburakawa Y, Takehara N, Fujino T, HasebeN, Narumiya S, Ushikubi F
  • Journal Title: Atheroscler.Thromb Vasc Biol Volume: 30 Pages: 464-470
• [Presentation] Administration of Beraprost inhibited metastasis in lung cancer (2013)
  • Author(s): Y Minami TSasaki, S Endo, K Shibukawa, JKawabe, M Kitada, Y Ohsaki
  • Organizer: AACR(アメリカ癌学会)
  • Place of Presentation: 米国(SanFrancisco)
  • Year and Date: 20130000
• [Presentation] Prostacyclin signal in endothelial progenitor cells is crucital for tumor neoangiogenesis and its growthS Okumura (2010)
  • Author(s): J Kawabe, T Sasaki, YMinami, N Hasebe, Y Ohski
  • Organizer: ISHR (国際心臓研究会)
  • Place of Presentation: 日本(京都)
  • Year and Date: 20100000