2012 Fiscal Year Final Research Report
Application of pharmacogenomics for treatment of pulmonary hypertension
| Project/Area Number |
22590849
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Chiba University |
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Principal Investigator |
TANABE Nobuhiro 千葉大学, 大学院・医学研究院, 准教授 (40292700)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAO Seiichiro 千葉大学, 医学部附属病院, 助教 (80431740)
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| Co-Investigator(Renkei-kenkyūsha) |
KIMURA Akinori 東京医科歯科大学, 難治疾患研究所, 教授 (60161551)
NAKANISHI Norihumi 独立行政法人国立循環器病研究センター, 心臓内科, 部長 (80164234)
KASAHARA Yasunori 千葉大学, 医学部附属病院, 講師 (60343092)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 肺高血圧症 / 遺伝薬 / オーダーメード医療 / 右心機能 / 慢性血栓塞栓性肺高血圧症 / 肺動脈性肺高血圧症 |
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| Research Abstract |
The purpose of this study is to elucidate genetic factors associated with response to therapy for pulmonary arterial hypertension in order to establish personalized therapy in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension, and also to find genetic factors related to right heart failure and prognosis. We found that time to clinical worsening after sildenafil was significantly shorter in the patients having combination of CC/CT genotypes of G protein)3 3 subunit gene (GNB3) polymorphism and deletion/deletion genotypes of ACE gene polymorphism. Neither GNB3 nor ACE gene polymorphisms were related to response to bosentan. The CC genotype of NOS 786C/T polymorphism predicted right heart failure. In CTEPH, combination of having T allele of Endothelin-1 lys198Asp(G/T) and TT genotypes of endothelin A receptor H323H (C/T) polymorphisms predicted poor prognosis.
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[Journal Article] A Phase III, Multicenter, Collaborative, Open-Label Clinical Trial of Sildenafil in Japanese Patients With Pulmonary Arterial Hypertension2011
Author(s)
Satoh T, Saji T, Watanabe H, Ogawa S, Takehara K, Tanabe N, Yamada N, Yao A, Miyaji K, Nakanishi N, Suzuki Y, Fujiwara T, Kuriyama T.
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Journal Title
Cir J 7
Volume: 5
Pages: 675-682
Peer Reviewed
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[Journal Article] Association of deep vein thrombosis type with clinical phenotype of chronic thromboembolic pulmonary hypertension2011
Author(s)
Kantake M, Tanabe N, Sugiura T, Shigeta A, Yanagawa N, Jujo T, Kawata N, Amano Matsuura Y, Nishimura R, Sekine A, Sakao S, et al
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Journal Title
Peer Reviewed
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[Presentation] 肺血管原性高血圧症における混合静脈血酸素分圧の予後に及ぼす影響について2012
Author(s)
関根亜由美,田邉信宏,坂尾誠一郎,西村倫太郎,笠井大,竹内孝夫,須田理香,加藤照史,重城喬行,重田文子,笠原靖紀,巽浩一郎
Organizer
第53回日本呼吸器学会学術講演会
Place of Presentation
神戸
Year and Date
20120420-22
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[Presentation] Improved survival in medically-treated chronic thromboembolic pulmonary hypertension2011
Author(s)
Nishimura R, Tanabe N, Ichimura Y, Sekine A, Sugiura T, Jujo T, Shigeta A, Sakao S, Kasahara Y, et al
Organizer
ERS Annual Congress 2011
Place of Presentation
Amsterdam, Netherlands
Year and Date
20110926-28
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[Presentation] 肺高血圧症におけるシルデナフィルの効果とGproeinβ3 subunit遺伝子多型との関連について2011
Author(s)
関根亜由美,田邉信宏,北園聡,北園美弥子,西村倫太郎,高田由子,重城喬行,杉浦寿彦,安田直史,叛尾誠一郎,笠原靖紀,滝口裕一,巽浩一郎
Organizer
第51回日本呼吸・器学会学術講演会
Place of Presentation
東京
Year and Date
20110422-23
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[Presentation] Identification of novel diagnostic biomarkers of chronic thromboembolic pulmonary hypertension using MALDITOF-MS2010
Author(s)
Yano T, Sogawa K, Satoh M, Umemura H, Sugiura T, Kitazono S, Yamauchi K, Sakao S, Kasahara Y, Tanabe, N., et al
Organizer
The 20th European Respiratory Society meeting
Place of Presentation
BARCELONA, spain
Year and Date
20100918-22
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