2012 Fiscal Year Final Research Report
Gene polymorphisms in patients with sleep apnea and cell responses to hypoxia
| Project/Area Number |
22590860
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
TSUBOI Tomomasa 京都大学, 医学(系)研究科(研究院), 非常勤講師 (00536724)
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| Co-Investigator(Kenkyū-buntansha) |
CHIN Kazuo 京都大学, 医学(系)研究科(研究院), 教授 (90197640)
HORIUCHI Hisanori 東北大学, 加齢研究所, 教授 (90291426)
HOSHINO Yuma 京都大学, 医学(系)研究科(研究院), 助教 (00378746)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 閉塞型睡眠時無呼吸 / 遺伝子多型 / 持続的低酸素 / 間欠的低酸素 |
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| Research Abstract |
It is said that patients with severe obstructive sleep apnea (OSA) show higher mortality than controls because of a significant increase in cardiovascular diseases in the former. However, not all but some of the patients with severe OSA have poor prognosis. We hypothesized that the differences in mortality rate among the patients with severe OSA were due to the genetic polymorphism. We have got the blood from 306 patients with OSA and done the gene extraction from them. In addition, we found thatUrinary Lipocalin-type prostaglandin D synthase (L-PGDS) might be a moderately useful marker to identify patients with severe OSA. We also made a new instrument which could produce both intermittent and sustained hypoxic conditions for the target cells. From that instrument, we could find that the intermittent hypoxia induced TNF-α and sustained hypoxia induced hypoxia inducible factor-1.
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[Journal Article] Flexible positive airway pressure improves treatment adherence compared with auto-adjusting PAP2013
Author(s)
Chihara Y, Tsuboi T, Hitomi T, Azuma M, Murase K, Toyama Y, Harada Y, Aihara K, Tanizawa K, Handa T, Yoshimura C, Oga T, Yamamoto K, Mishima M, Chin K
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Journal Title
DOI
Peer Reviewed
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[Journal Article] Analysis of anatomical and functional determinants of obstructive sleep apnea2012
Author(s)
Aihara K, Oga T, Harada Y, Chihara Y, Handa T, Tanizawa K, Watanabe K, Hitomi T, Tsuboi T, Mishima M, Chin K
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Journal Title
Sleep Breath
Volume: 16: 473-81
DOI
Peer Reviewed
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[Journal Article] Importance of the PaCO2from 3 to 6 months after initiation of long-term non-invasive ventilation2010
Author(s)
Tsuboi T, Ohi M, Oga T, Machida K, Chihara Y, Harada Y, Takahashi K, Sumi K, Handa T, Niimi A, Mishima M, Chin K
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Journal Title
Respir Med
Volume: 104:1850-7
DOI
Peer Reviewed
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[Journal Article] Noninvasive ventilation improves the outcome of pulmonary complications after liver resection2010
Author(s)
Narita M, Tanizawa K, Chin K, Ikai I, Handa T, Oga T, Niimi A, Tsuboi T, Mishima M, Uemoto S, Hatano E
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Journal Title
Intern Med
Volume: 49: 1501-7
DOI
Peer Reviewed
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[Journal Article] A urine biomarker for severe OSA: Lipocaline-Type prostaglandin D synthase
Author(s)
Chihara Y, Chin K, Aritake K, Harada Y, Toyama Y, Murase K, Yoshimura C, Hitomi T, Oga T, Mishima M, Urade Y
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Journal Title
European Respiratory Journal
Volume: (in press)
Peer Reviewed
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