2012 Fiscal Year Final Research Report
Studies of epigenetic abnormalities in chronic kidney disease as a novel therapeutic target
| Project/Area Number |
22590879
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | The University of Tokyo (2010, 2012)
Kyorin University (2011) |
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Principal Investigator |
MARUMO Takeshi 東京大学, 先端科学技術研究センター, 特任講師 (70265817)
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| Co-Investigator(Kenkyū-buntansha) |
HIRAHASHI Junichi 東京大学, 医学部附属病院, 助教 (70296573)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 慢性腎臓病 / 糖尿病性腎症 / ヒストン脱アセチル化酵素 / DNA メチル化 |
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| Research Abstract |
Epigenetic mechanisms act like a switch of gene activation. Organ dysfunction is characterized by altered phenotype of each components of the affected organ. The present study revealed that epigenetic mechanisms are involved in the development of phenotype switch such as fibrotic and pro-inflammatory changes of the kidney cells, observed in chronic kidney disease. Epigenetic abnormalities can be a novel target for thechronic kidney disease.
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