2012 Fiscal Year Final Research Report
Establishment of immune complex-mediated disease models by human patient sera
| Project/Area Number |
22590885
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
TSUBOI Naotake 名古屋大学, 医学部附属病院, 講師 (50566958)
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| Co-Investigator(Kenkyū-buntansha) |
YUZAWA Yukio 藤田保健衛生大学, 医学部, 教授 (00191479)
MARUYAMA Shoichi 名古屋大学, 大学院・医学系研究, 准教授 (10362253)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 好中球 / 全身性ループスエリテマトーデス / インテグリン / Fc 受容体 |
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| Research Abstract |
In newly established animal model of lupus nephritis induced by passive transfer of human systemic lupus erhythematosus (SLE) sera, essential role of human FcγRIIA and protective role of Mac-1 for disease induction were elucidated. The Pristine-induced SLE model demonstrated dual roles of Mac-1 as promoting pulmonary hemorrhage and as protective against lupus nephritis.
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