2012 Fiscal Year Final Research Report
Role of the interferon regulatory factor 5 in the development of lupus nephritis
| Project/Area Number |
22590893
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Saga University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOARADA Syuichi 佐賀大学, 医学部, 講師 (50304887)
NAGASAWA Kohei 佐賀大学, 佐賀大学, 教授 (00108721)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 腎臓学 |
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| Research Abstract |
Interferon regulatory factor 5 (IRF5) is a transcription factor and considered to be involved in the development of systemic lupus erythematosus. We generated IRF5-deficient lupus (MRL/lpr) mice and investigated their phenotype. Autoantibodies to nuclear antigens, including anti-nuclear antibodies and anti-dsDNA antibodies were lower or negative in the mouse sera. Lupus nephritis was much milder, and the mice survive much longer than control MRL/lpr mice. Splenic dendritic cells produced lower levels of inflammatory cytokines in response to To l l-like receptor ligands. These results show that IRF5 is a crucial driver of lupus nephritis and indicate that IRF5 may be an attractive new target for the treatment of lupus nephritis.
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