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2012 Fiscal Year Final Research Report

Impairment of neurovasculaer unit under chronic hypoperfusion

Research Project

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Project/Area Number 22590929
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionMie University

Principal Investigator

YATA Kenichiro  三重大学, 大学院・医学系研究科, 産学官連携研究員 (40467361)

Co-Investigator(Kenkyū-buntansha) TOMIMOTO Hidekazu  三重大学, 大学院・医学系研究科, 教授 (80324648)
Project Period (FY) 2010 – 2012
Keywords神経分子病態学 / small vessel disease / chronic cerebral hypoperfuion / Two-photon microscopy / capillary plugging / rolling and adhesion
Research Abstract

To understand the role of chronic cerebral hypoperfusion in cerebral small vessel disease, repeated longitudinal in vivo imaging was performed by using two-photon microscopy. Under chronic hypoperfuion, leukocyte plugging in deep capillary and leukocyte rolling and adhesion in pial vessel were detected.

  • Research Products

    (5 results)

All 2013 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results)

  • [Journal Article] Clinical and neuropathological findings in a patient with familial Alzheimer disease showing a mutation in the PSEN1 gene2013

    • Author(s)
      Niwa A, MatsuoK, Shindo A, Yata K,Tomimoto H.
    • Journal Title

      Neuropathology

      Volume: 33 Pages: 199-203

    • Peer Reviewed
  • [Journal Article] Attenuation of brain damage and cognitive impairment by direct renin inhibition in mice with chronic cerebral hypoperfusion.2011

    • Author(s)
      Dong YF, Kataoka K, Toyama K, Sueta D, Koibuchi N, Yamamoto E, Yata K, Tomimoto H, Ogawa H, Kim-Mitsuyama S
    • Journal Title

      Hypertension.

      Volume: 58 Pages: 635-42

    • Peer Reviewed
  • [Presentation] 光子励起レーザー顕微鏡を用いたマウス慢性脳低灌流状態における微小循環動態の評価2012

    • Author(s)
      矢田健一郎
    • Organizer
      第37回 日本脳卒中学会
    • Place of Presentation
      福岡
    • Year and Date
      2012-04-27
  • [Presentation] 2光子励起レーザー顕微鏡を用いた頸動脈閉塞症の微小循環動態のreal time観察2011

    • Author(s)
      矢田健一郎
    • Organizer
      第52回日本神経学会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-05-18
  • [Presentation] 光子励起レーザー顕微鏡を用いたマウス頚動脈狭窄性病変モデルにおける血行動態の評価2011

    • Author(s)
      矢田健一郎
    • Organizer
      第36回日本脳卒中学会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-25

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Published: 2014-08-29   Modified: 2015-09-01  

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