2012 Fiscal Year Final Research Report
Elucidation of the role of microglia in the pathogenesis of neurological disorders.
| Project/Area Number |
22590945
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Fujita Health University |
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Principal Investigator |
MUTOH Tatsurou 藤田保健衛生大学, 医学部, 教授 (60190857)
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| Co-Investigator(Kenkyū-buntansha) |
SAWADA Makoto 名古屋大学, 医学部, 教授 (10187297)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ミクログリア |
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| Research Abstract |
Recent advances on the understanding of microglia have revealed that microglia plays important roles on the development and propagation of neurological disorders, which are recruited to the lesions of the brain. What are these recruited microglia doing on the lesions of central nervous system? Previous reports including ours have demonstrated that there are two different microglia, one is acting as neuroprotective roles and other as neurotoxic roles on neurons. At present, however, the molecular mechanisms for two different phenotypes of microglia remain to be elucidated. In this study, we tried to characterize these cells from the neuro-glycobiological point of view and found that there is an obvious difference of the contents of neutral glycosphingolipids. These differences of neutral glycosphingolipid contents seem to determine their biological and immunological property.
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[Journal Article] Potential therapeutic system for Alzheimer's disease: removal of blood Aβs by hemodialzyers and its effect on the cognitive functions of renal-failure patients.2012
Author(s)
Kato M, Kawaguchi K, Nakai S, Murakami K, Hori H, Ohashi A, Hiki Y, Ito S, Shimano Y, Suzuki N, Sugiyama S, Ogawa H, Kusimoto H, Mutoh T, Yuzawa Y, Kitaguchi N.
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Journal Title
J Neural Transm.
Volume: 119(12)
Pages: 1533-44
Peer Reviewed
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[Journal Article] Abnormal cross-talk between mutant presenilin 1 (I143T, G384A) and glycosphingolipid biosynthesis.2012
Author(s)
Mutoh T, Kawamura N, Hirabayashi Y,Shima S, Miyashita T, Ito S, Asakura K, Cazzaniga E, Muto E, Masserini M.
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Journal Title
FASEBJ
Volume: 26
Pages: 3065-3074
Peer Reviewed
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[Journal Article] Reduction of Alzheimer's Disease Amyloid β inplasma by hemodialysis and its relation to cognitive functions.2011
Author(s)
Kitaguchi N, Kawaguchi K, Nakai S, Murakami K, Ito S, Hoshino H, Hori H, Ohashi A, Shimano Y, Suzuki N, Yuzawa Y, Mutoh T, Sugiyama S.
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Journal Title
Blood Purifi
Volume: 32
Pages: 57-62
Peer Reviewed
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[Journal Article] Levels Of Neurotrophins In Cerebrospinal Fluids From Adult Patients WithMeningoencephalitis.2011
Author(s)
Kizawa-Ueda M, Ueda A, Kawamura N, Ishikawa T, Mutoh E, Fukuda Y, Shiroki R, Hoshinaga K, Ito S, Asasakura K, and Mutoh T.
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Journal Title
Eur Neurol
Volume: 65
Pages: 138-43
Peer Reviewed
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