2012 Fiscal Year Final Research Report
Analysis about the factors that affect the postnatal formationand function of pancreatic β-cell in connection with the intrauterine undernutrition.
| Project/Area Number |
22590976
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kyoto University |
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Principal Investigator |
TOYODA Kentaro 京都大学, 医学(系)研究科, 講師 (00447971)
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| Co-Investigator(Kenkyū-buntansha) |
HAMAZAKI Akihiro 京都大学, 医学(系)研究科, 助教 (40456900)
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| Project Period (FY) |
2010 – 2012
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| Keywords | エネルギー / 糖質代謝異常 / イメージング |
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| Research Abstract |
The aim of this study is to analyze the factors that affect the postnatal formation of pancreatic β-cell mass and function in connection with the intrauterine undernutrition. Although, pregnant mice were divided into two groups; calorie restriction group and control diet group, an individual difference of the daily intake volume severely large unexpectedly. Therefore, in the period of this project, we could not compare with both groups. For detail observation of the change in pancreatic β-cell mass during embryonic and postnatal period, we analyzed the pregnant mice and fetal mice whose pancreatic β-cell express luciferase by using IVIS system and optical projection tomography (OPT). Luciferine injection enabled us to observe the mass of fetal islets in the pregnant mice by IVIS and the number and volume of fetal islet were quantified by OPT analysis.
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[Presentation] Development of Non-Invasive PET Probe for Quantifying Pancreatic B-Cell Mass Using Fluorine-18-Labeled Exendin-42012
Author(s)
Fujimoto, H., Toyoda, K., Kimura, H., Saji, H., Inagaki, N (他 8 人)
Organizer
9th International Diabetes Federation Western Pacific Region Congress / 4th Scientific Meeting of the Asian Association for the Study of Diabetes
Place of Presentation
Kyoto, Japan
Year and Date
2012-11-27
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