2012 Fiscal Year Final Research Report
The elucidation of antihyperglycemic action mechanism in the liver and pancreatic beta cells of bile acid resin
| Project/Area Number |
22590989
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Yokohama City University |
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Principal Investigator |
YAMAKAWA Tadashi 横浜市立大学, 市民総合医療センター, 准教授 (30264641)
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| Co-Investigator(Kenkyū-buntansha) |
TERAUCHI Yasuo 横浜市立大学, 医学研究科, 教授 (40359609)
OGIWARA Kikumi 麻布大学, 環境保健学部, 教授 (50154381)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 胆汁酸 |
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| Research Abstract |
The objective of this study was to assess the chronic effects of a bile acid sequestrant, colestimide, on glucose metabolism in type 2 diabetes..Colestimide significantly reduced the elevated fasting blood glucose level, and CA even more markedly reduced fasting blood glucose. A hyperinsulinemic-euglycemic clamp study revealed that colestimide alleviated insulin resistance by suppressing hepatic glucose production and increasing peripheral glucose usage. Colestimide suppressed SHP expression, but enhanced SREBP2 expression. On the other hand, CA increased the expression of SHP and lipogenic enzymes such as ACC and SCD-1, but had no effect on SREBP2.
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