• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2012 Fiscal Year Final Research Report

Hepatic and vascular insulin resistance in PI3kinase p85αdeficientmice

Research Project

  • PDF
Project/Area Number 22590990
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Metabolomics
Research InstitutionYokohama City University

Principal Investigator

AOKI Kazutaka  横浜市立大学, 医学部, 助教 (60336542)

Co-Investigator(Kenkyū-buntansha) TERAUCHI Yasuo  横浜市立大学, 医学研究科, 教授 (40359609)
Project Period (FY) 2010 – 2012
KeywordsPI3キナーゼp85α / 肝臓インスリン感受性
Research Abstract

Phosphoinositide 3-kinase (PI3K) p85alpha-deficient mice exhibit hypoglycemia as a result of increased insulin sensitivity and glucose uptake in peripheral tissues. We previouslyinvestigated hepatic glucose homeostasis in p85alpha-deficient and wild-type mice. Gluconeogenesis was rather elevated in p85alpha-deficient mice, compared with in wild-type mice. In this study, we evaluated the hepatic glucose production of primary hepatocyte in p85alpha-deficient and wild-type mice. Hepatic glucose production of primary hepatocyte in p85alpha-deficient mice was not decreased compared to that in wild type mice.

  • Research Products

    (25 results)

All 2013 2012 2011 2010

All Journal Article (15 results) (of which Peer Reviewed: 15 results) Presentation (4 results) Book (6 results)

  • [Journal Article] Trefoil Factor 2 Promotes Cell Proliferation in Pancreatic β-Cells through CXCR-4-Mediated ERK1/2 Phosphorylation2013

    • Author(s)
      Orime K, Shirakawa J, Togashi Y, Tajima K, Inoue H, Ito Y, Sato K, Nakamura A, Aoki K, Goshima Y, Terauchi Y
    • Journal Title

      Endocrinology

      Volume: 154(1) Pages: 54-64

    • Peer Reviewed
  • [Journal Article] Mosapride citrate, a 5-HT4 receptor agonist, increased the plasma active and total glucagon-like peptide-1 levels in non-diabetic men2013

    • Author(s)
      Aoki K, Kamiyama H, Masuda K, Togashi Y, Terauchi Y
    • Journal Title

      Endocr J

      Volume: 60(4) Pages: 493-499

    • Peer Reviewed
  • [Journal Article] Miglitol administered before breakfast increased plasma active glucagon-like peptide-1 (GLP-1) levels after lunch in patients with type 2 diabetes treated with sitagliptin2012

    • Author(s)
      Aoki K, Kamiyama H, Yoshimura K, Shibuya M, Masuda K, Terauchi Y
    • Journal Title

      Acta Diabetol

      Volume: 49(3) Pages: 225-230

    • Peer Reviewed
  • [Journal Article] Comparison of plasma active glucagon-like peptide-1 (GLP-1) levels assayed with or without plasma extraction in non-diabetic men2012

    • Author(s)
      Masuda K, Aoki K, Terauchi Y
    • Journal Title

      Endocr J

      Volume: 59(5) Pages: 435-438

    • Peer Reviewed
  • [Journal Article] Effect of acarbose therapy once or twice a day on blood glucose in Japanese patients with type 2 diabetes2012

    • Author(s)
      Aoki K, Terauchi Y
    • Journal Title

      Jpn J Clin Pharmacol Ther

      Volume: 43 Pages: 17-20

    • Peer Reviewed
  • [Journal Article] Diet-induced adipose tissue inflammation and liver steatosis are prevented by DPP-4 inhibition in diabetic mice2011

    • Author(s)
      Shirakawa J, Fujii H, Ohnuma K, Sato K, Ito Y, Kaji M, Sakamoto E, Koganei M, Sasaki H, Nagashima Y, Amo K,Aoki K, Morimoto C, Takeda E, Terauchi Y
    • Journal Title

      Diabetes

      Volume: 60(4) Pages: 1246-57

    • Peer Reviewed
  • [Journal Article] Ezetimibe decreases SREBP-1c expression in liver and reverses hepatic insulin resistance in mice fed a high-fat diet2011

    • Author(s)
      Muraoka T, Aoki K, Iwasaki T, Shinoda K, Nakamura A, Aburatani H, Mori S, Tokuyama K, Kubota N, Kadowaki T, Terauchi Y.
    • Journal Title

      Metabolism

      Volume: 60(5) Pages: 617-628

    • Peer Reviewed
  • [Journal Article] Effects of miglitol taken just before or after breakfast on plasma glucose, serum insulin, glucagon and incretin levels after lunch in men with normal glucose tolerance, impaired fasting glucose or impaired glucose tolerance2011

    • Author(s)
      Masuda K, Aoki K, Terauchi Y
    • Journal Title

      J Diabetes Invest

      Volume: 3(6) Pages: 435-440

    • Peer Reviewed
  • [Journal Article] Effects of pre-meal versus post-meal administration of miglitol on plasma glucagon-like peptide-1 and glucosedependent insulinotropic polypeptide levels in healthy men2010

    • Author(s)
      Aoki K,Miyazaki T, Nagakura J, Orime K, Togashi Y, Terauchi Y
    • Journal Title

      Endocr J

      Volume: 57(8) Pages: 673-677

    • Peer Reviewed
  • [Journal Article] Effects of miglitol, sitagliptin or their combination on plasma glucose, insulin and incretin levels in non-diabetic men.2010

    • Author(s)
      Aoki K, Masuda K, Miyazaki T, Togashi Y, Terauchi Y
    • Journal Title

      Endocr J

      Volume: 57(8) Pages: 667-672

    • Peer Reviewed
  • [Journal Article] Comparison of adverse gastrointestinal effects of acarbose and miglitol in healthy men: A crossover study.2010

    • Author(s)
      Aoki K,Muraoka T, Ito Y, Togashi Y, Terauchi Y
    • Journal Title

      Intern Med

      Volume: 49(12) Pages: 1085-1087

    • Peer Reviewed
  • [Journal Article] Self-Injection of Insulin Using Appropriate Supportive Devices in Handicapped Subjects with Diabetes.2010

    • Author(s)
      Masuda K, Aoki K, Kikuchi K, Nezu U, Muraoka T, Shinoda K, Nakamura A, Shibuya M, Takahashi M, Kimura M, Terauchi Y
    • Journal Title

      Diabetes Technol Ther

      Volume: 12(6) Pages: 483-490

    • Peer Reviewed
  • [Journal Article] Pravastatin potentiates increases in serum adiponectin concentration in dyslipidemic patients receiving thiazolidinedione: the DOLPHIN study2010

    • Author(s)
      Nezu U, Tsunoda S, Yoshimura H, Kuwabara T, Tomura S, Seki Y, Kaneshiro M, Kamiyama H, Harada Y, Shigematsu E, Aoki K, Yamakawa T, Ohshige K, Natsumeda Y, Terauchi Y
    • Journal Title

      J Atheroscler Thromb

      Volume: 17(10) Pages: 1063-1069

    • Peer Reviewed
  • [Journal Article] Correlations of Fasting and Postprandial Blood Glucose Increments to the Overall Diurnal Hyperglycemic Status in Type 2 Diabetic Patients: Variations with Levels of HbA1c2010

    • Author(s)
      Kikuchi K, Nezu U, Shirakawa J, Sato K, Togashi Y, Kikuchi T, Aoki K, Ito Y, Kimura M, Terauchi Y
    • Journal Title

      Endocr J

      Volume: 57(3) Pages: 259-266

    • Peer Reviewed
  • [Journal Article] Problems in diagnosing atypical Gitelman's syndrome presenting with normomagnesaemia2010

    • Author(s)
      Nakamura A, Shimizu C, Nagai S, Yoshida M, Aoki K, Kondo T,Miyoshi H, Wada N, Tajima T, Terauchi Y,Yoshioka N, Koike T
    • Journal Title

      Clin Endocrinol (Oxf)

      Volume: 72(2) Pages: 272-276

    • Peer Reviewed
  • [Presentation] 「糖尿病の診断・治療の最新情報」教育講演2012

    • Author(s)
      青木一孝、寺内康夫
    • Organizer
      日本臨床検査自動化学会第44回大会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2012-10-13
  • [Presentation] モサプリドがインクレチン分泌に与える効果2012

    • Author(s)
      青木一孝, 増田清美, 神山博史, 寺内康夫
    • Organizer
      第55回日本糖尿病学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2012-05-17
  • [Presentation] 日本人2型糖尿病患者におけるアカルボースの1日1~2回投与による血糖改善効果2011

    • Author(s)
      青木一孝, 神山博史, 吉村公一郎, 増田清美, 寺内康夫
    • Organizer
      第54回日本糖尿病学会学術総会
    • Place of Presentation
      さっぽろ芸術文化の館(北海道)
    • Year and Date
      2011-05-19
  • [Presentation] ミグリトールの内服方法がインクレチン分泌に与える影響2010

    • Author(s)
      青木一孝, 宮崎岳之, 永倉穣, 折目和基, 富樫優, 寺内康夫
    • Organizer
      第53回日本糖尿病学会学術総会
    • Place of Presentation
      ホテルグランヴィア岡山(岡山県)
    • Year and Date
      2010-05-27
  • [Book] 経口血糖降下薬. 内分泌代謝専門医ガイドブック科改訂第3版2012

    • Author(s)
      青木一孝・寺内康夫
    • Total Pages
      337-341
    • Publisher
      診断と治療社
  • [Book] 循環器から寄せられる「糖尿病と血管合併症」に関する100の質問2012

    • Author(s)
      青木一孝・寺内康夫
    • Total Pages
      106-107
    • Publisher
      メディカルレビュー社
  • [Book] 糖尿病の血糖管理. Principles and Practice内分泌代謝(寺内康夫、鯉淵典行、後藤英司編)2011

    • Author(s)
      青木一孝・寺内康夫
    • Total Pages
      272-273
    • Publisher
      文光堂
  • [Book] 経口血糖薬の使い分け. 寺内康夫編EBM糖尿病ハンドブック2011

    • Author(s)
      青木一孝・寺内康夫
    • Total Pages
      227-236
    • Publisher
      中外医学社
  • [Book] 結果の記載方法. コメディカルのための論文の書き方の基礎知識2010

    • Author(s)
      青木一孝・寺内康夫
    • Total Pages
      73-76
    • Publisher
      メディカルレビュー社
  • [Book] 方法と対象の記載方法. コメディカルのための論文の書き方の基礎知識2010

    • Author(s)
      青木一孝・寺内康夫
    • Total Pages
      67-72
    • Publisher
      メディカルレビュー社

URL: 

Published: 2014-08-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi