2012 Fiscal Year Final Research Report
Analysis of adult T-cell leukemia cells using multi-color flow cytometry can detect high risk asymptomatic HTLV-1 carriers to progress into adult T-cell leukemia.
| Project/Area Number |
22591028
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Hematology
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
UCHIMARU Kaoru 東京大学, 医科学研究所, 准教授 (60251203)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
WATANABE Nobukazu 東京大学, 医科学研究所, 特任准教授 (10334278)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | HTLV-1 / ATL / FACS / TSLC1 / CADM1 / CD7 |
|---|
| Research Abstract |
ATL cells can be detected as CADM1+/CD7- cells using multi-color fllow cytometry and this analysis is helpful for monitoring therapeutic effect for ATL. This technique can purify the cells in intermediate state of oncogensis of HTLV-1 infected cells to ATL as CADM1+/CD7dim cells. These CADM1+/CD7dim cells is detected in the peripheral blood of a part of asymptomatic carriers at high risk to develop ATL.
|
-
-
[Journal Article] The CD3 versus CD7 plot in multicolor flow cytometry reflects progression of disease stage in patients infected with HTLV-I.2013
Author(s)
Kobayashi S, Tian Y, Ohno N, Yuji K, Ishigaki T, Isobe M, Ohfuchi-Tsuda M, Oyaizu N, Watanabe E, Watanabe N, Tani K, Tojo A and Uchimaru K.
-
Journal Title
PLoS One
Volume: 8
Pages: e53728
DOI
Peer Reviewed
-
-
[Journal Article] Polycomb-Mediated Loss of miR-31Activates NIK-dependent NF-κ B Pathway in Adult T-cell Leukemia and Other Cancers.2011
Author(s)
Makoto Yamagishi, Kazumi Nakano, Ariko Miyake, Tadanori Yamochi, Yayoi Kagami, Akihisa, Tsutsumi, Yuka Matsuda, Aiko Sato-Otsubo, Satsuki Muto, Atae Utsunomiya, Kazunari Yamaguchi, Kaoru Uchimaru, Seishi Ogawa, and Toshiki Watanabe.
-
Journal Title
Cancer cell.
Volume: 21(1)
Pages: 121-135
Peer Reviewed
-
[Journal Article] Human T-cell leukemiavirus type I (HTLV-1) proviral load and disease progression in asymptomatic HTLV-1 carriers: a nationwide prospective study in Japan.2010
Author(s)
Masako Iwanaga, Toshiki Watanabe, Atae Utsunomiya, Akihiko Okayama,Kaoru Uchimaru, Ki-Ryang Koh, Masao Ogata, Hiroshi Kikuchi, Yasuko Sagara, Kimiharu Uozumi, Manabu Mochizuki, Kunihiro Tsukasaki, Yoshio Saburi, Masaomi Yamamura, Junji Tanaka, Yukiyoshi Moriuchi, Shigeo Hino, Shimeru Kamihira, and Kazunari Yamaguchi.
-
Journal Title
Blood
Volume: 116(8)
Pages: 1211-9
Peer Reviewed
-
[Journal Article] Adult T-cell leukemia cells are characterized by abnormalities of Helios expression that promote T-cell growth.
Author(s)
Asanuma S, Yamagishi M, Kawanami Ka, Nakano K, Sato-Otsubo A, Muto S, Sanada M, Yamochi T, Kobayashi S, Utsunomiya A, Iwanaga M, Yamaguchi K, Uchimaru K, Ogawa S and Watanabe T.
-
Journal Title
Cancer Sci.
Volume: in press.
Peer Reviewed
-
-
-
-
-
