2012 Fiscal Year Final Research Report
Investigation of pathogenesis of hematological malignancies by analyzing balanced and unbalanced chromosomal translocations
| Project/Area Number |
22591037
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUI Toshimitsu 神戸大学, 医学研究科, 准教授 (10219371)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 染色体転座 / 悪性リンパ腫 / TFL 遺伝子 / 骨髄異形成症候群 |
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| Research Abstract |
A novel gene TFL was cloned at the 6q25 breakpoint of a balanced translocation t(2;6)(p12;q25) appearing during transformation from follicular lymphoma to diffuse large B-cell lymphoma. In this study, we establishedTFL knockout mice and analyzed TFL function. We also examined the expression and structural abnormality of TFL in malignant lymphomas. Next, we characterized clinical and hematological features of myelodysplastic syndromes with a novel unbalanced translocationder(5;19)(p10;q10). Furthermore, we identified several rare balanced or unbalanced translocations from newly diagnosed cases of hematological malignancies.
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Research Products
(20 results)
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[Journal Article] Pharmacokinetics-based optimal dose prediction of mycophenolate mofetil in unrelated hematopoietic cell transplantation depending on donor source2011
Author(s)
Wakahashi K, Yamamori M, Minagawa K, Ishii S, Nishikawa S, Shimoyama M, Kawano H, Kawano H, Kawamori Y, Sada A, Matsui T, Katayama Y.
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Journal Title
Int. J. Hematol
Volume: 94巻
Pages: 193-202
DOI
Peer Reviewed
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[Journal Article] Role for vitamin D receptor in the neuronal control of the hematopoietic stem cell niche2010
Author(s)
Kawamori Y, Katayama Y, Asada N, Minagawa K, Sato M, Okamura A, Shimoyama M, Nakagawa K, Okano T, Tanimoto M, Kato S, Matsui T
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Journal Title
Blood
Volume: 116巻
Pages: 5528-5535
DOI
Peer Reviewed
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