2012 Fiscal Year Final Research Report
Interaction between NPM1 which is deeply related with the prognosisof leukemia and the ETS family of transcription factor, MEF
Project/Area Number |
22591040
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Hematology
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Research Institution | Nagasaki University |
Principal Investigator |
MIYAZAKI Yasushi 長崎大学, 大学院・医歯薬学総合研究科, 教授 (40304943)
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Co-Investigator(Renkei-kenkyūsha) |
ANDO Koji 長崎大学, 大学病院, 医員 (90571357)
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Project Period (FY) |
2010 – 2012
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Keywords | 血液腫瘍学 |
Research Abstract |
Myeloid ELF1-like factor (MEF), a member of the ETS transcription factors, can function as an oncogene. We found that MEF directly forms a complex with NPM1. Functional analyses showed that wild-type NPM1 inhibited the DNA-binding and transcriptional activity of MEF on the HDM2 promoter whereas NPM1 mutant protein (Mt-NPM1) enhanced these activities of MEF. It also related to the transformation of NIH3T3 cells by MEF. In addition, clinical leukemia samples with NPM1 mutations had higher HDM2 mRNA expression. Our data suggest that enhanced HDM2 expression induced by mutant NPM1 may have a role in MEF/ELF4-dependent leukemogenesis. (J Biol Chem 2013;288(13):9457-67.)
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Research Products
(28 results)
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[Presentation] Incidence and Clinical Features of Core Binding Factor Acute Myeloid Leukemia: A Collaborative Study of the Japan Adult Leukemia Study Group and the Korean Society of Hematology2012
Author(s)
Tomohiko Taki, Hee-Je Kim, Shigeki Ohtake, Byung-Sik Cho, Hitoshi Kiyoi, Woo-Sung Min, Norio Asou, So-Young Choi, Yasushi Miyazaki, Yeo-Kyeoung Kim, Hisashi Sakamaki, June-Won Cheong, Sumihisa Honda, Shuichi Miyawaki, Masafumi Taniwaki, Hyeoung-Joon Kim, Tomoki Naoe, and Yoo-Hong Min
Organizer
54th ASH Annual Meeting and Exposition
Place of Presentation
Atlanta, USA
Year and Date
20121208-11
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[Presentation] A Phase III Study of New Synthetic Retinoid Tamibarotene (Am80) Compared with ATRA in Maintenance Therapy for Newly Diagnosed Acute Promyelocytic Leukemia (APL): Japan Adult Leukemia Study Group (JALSG) APL204 Study2012
Author(s)
Katsuji Shinagawa, Shigeki Ohtake, Toru Sakura, Yasunori Ueda, Masashi Sawa, Jun-ichi Miyatake, Noriko Usui, Makoto Onitsuka, Yoshihiro Hatta, Nobuhiko Emi, Shigehisa Tamaki, Yoshikazu Ito, Toru Murayama, Hiroyuki Fujita, Katsumichi Fujimaki, Norio Asou, Akihiro Takeshita, Yasushi Miyazaki, Shuichi Miyawaki, Kazunori Ohnishi, Tomoki Naoe, and Ryuzo Ohno
Organizer
54th ASH Annual Meeting and Exposition
Place of Presentation
Atlanta, USA
Year and Date
20121208-11
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[Presentation] Unfavorable Outcome of Single-Unit Umbilical Cord Blood Transplantation for Elderly Patients with Myelodysplastic Syndromes2012
Author(s)
Kazunari Aoki, Ken Ishiyama, Hidehiro Itonaga, Takahiro Fukuda, Shuichi Taniguchi, Yasunori Ueda, Noriko Doki, Yasuhiro Sugio, Yasuo Morishima, Tokiko Nagamura, Junji Tanaka, Yoshiko Atsuta, Takayuki Ishikawa, and Yasushi Miyazaki
Organizer
54th ASH Annual Meeting and Exposition
Place of Presentation
Atlanta, USA
Year and Date
20121208-11
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[Presentation] Expression of CD56 Is an Independent Prognostic Factor to Predict Relapse in Acute Myeloid Leukemia with t(8;21): Results of Japan Adult Leukemia Study Group (JALSG) AML97 Protocol2012
Author(s)
Noriyoshi Iriyama, Yoshihiro Hatta, Jin Takeuchi, Yoshiaki Ogawa, Shigeki Ohtake, Toru Sakura, Kinuko Mitani, Fumihiro Ishida, Masatomo Takahashi, Tomoya Maeda, Tohru Izumi, Hisashi Sakamaki, Shuichi Miyawaki, Sumihisa Honda, Yasushi Miyazaki, Tomohiko Taki, Masafumi Taniwaki, and Tomoki Naoe
Organizer
54th ASH Annual Meeting and Exposition
Place of Presentation
Atlanta, USA
Year and Date
20121208-11
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[Presentation] Outcome of Pediatric-Type Therapy for Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia (ALL) in Adolescents and Young Adults (AYA): A Study by the Japan Adult Leukemia Study Group (JALSG ALL202-U study)2012
Author(s)
Toru Sakura, Fumihiko Hayakawa, Toshiaki Yujiri, Yasutaka Aoyama, Eisei Kondo, Katsumichi Fujimaki, Yasunori Ueda, Shigeki Ohtake, Yasushi Miyazaki, Shuichi Miyawaki, Kazunori Ohnishi, and Tomoki Naoe
Organizer
54th ASH Annual Meeting and Exposition
Place of Presentation
Atlanta, USA
Year and Date
20121208-11
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[Presentation] Evaluation of the ELN genetic risk classification in AML patients registered to JALSG AML201 study.2012
Author(s)
Rika Kihara, Hitoshi Kiyoi, Takahiro Kato, Erina Yamamoto, Shigeki Ohtake, Shuichi Miyawaki, Yasushi Miyazaki, Norio Asou, Toru Sakura, Yukiyasu Ozawa, Noriko Usui, Heiwa Kanamori, Toru Kiguchi, Kiyotoshi Imai, Naokuni Uike, Fumihiko Kimura, Kunio Kitamura, Chiaki Nakaseko, Kosuke Tsuboi, Akihiko Takeshita, Fumihiro Ishida, Hitoshi Suzumura, Yuichi Kato, Hiroshi Miwa, Tomoki Naoe
Organizer
第74回日本血液学会学術集会
Place of Presentation
京都
Year and Date
2012-10-21
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[Presentation] The usefulness of WT1 mRNA expression levels as a monitoring marker of MDS progression2012
Author(s)
Sumiko Kobayashi, Jin Takeuchi, Yasunori Ueda, Mineo Kurokawa, Hideto tamura, Kiyoyuki Ogata, Kazuo Dan, Hirohiko Shibayama, Rika Kihara, Nobuhiko Emi, Toshiko Motoji, Koh Sasaki, Kensuke Usuki, Hiroyasu Ogawa, Toru Sakura, Kazuma Ohyashiki, Keiya Ozawa, Kiyotoshi Imai, Yasushi Miyazaki, Yasuyoshi Morita, Akira Matsuda, Kaoru Tohyama, Keiji Kumamoto, Daisuke Koga, Hiroya Tamaki, Kinuko Mitani, Tomoki Naoe, Haruo Sugiyama, Fumimaro Takaku
Organizer
第74回日本血液学会学術集会
Place of Presentation
京都
Year and Date
2012-10-21
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[Presentation] Proliferation of donor-derived HTLV-1 infected cells in an ATL patient after allogeneic PBSCT2012
Author(s)
Masataka Taguchi, Jun Taguchi, Daisuke Sasaki, Takeharu Kato, Makiko Hourai, Hidehiro Itonaga, Yoshitaka Imaizumi, Daisuke Imanishi, Hideki Tsushima, Tomoko Hata, Takuya Fukushima, Kunihiro Tsuakasaki, Shimeru Kamihira, Yasushi Miyazaki
Organizer
第74回日本血液学会学術集会
Place of Presentation
京都
Year and Date
2012-10-19
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[Presentation] Cord blood transplantation for adult T-cell leukemia/lymphoma : The JSHCT WG study2012
Author(s)
Koji Kato, Ilseung Cho, Atsushi Wake, Naokuni Uike, Shuichi Taniguchi, Yukiyoshi Moriuchi, Yasushi Miyazaki, Masayuki Hino, Koichi Akashi, Hisashi Sakamaki, Koji Kato, Ritsuko Suzuki, Takeharu Yamanaka, Atae Utsunomiya
Organizer
第74回日本血液学会学術集会
Place of Presentation
京都
Year and Date
2012-10-19
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[Presentation] The 3rd JSH International Symposium 2012 in Kawagoe:Ve ry Long-term Follow-up Results of Tyrosine Kinase Inhibitor Therapy in Newly Diagnosed Chronic Myeloid Leukemia:Nagasaki CML Study Group Experience2012
Author(s)
Hidehiro Itonaga, Tomoko Hata, Hideki Tsushima, Hiroaki Tanigucih, Junya Makiyama, Shinya Sato, Emi Matsuo, Reishi Yamasaki, Daisuke Ogawa, Yumi Takasaki, Daisuke Imanishi, Yoshitaka Imaizumi, Yasuhisa Kawaguchi, Tatsuro Joh, Shinichiro Yoshida, Masaomi Yamamura, Hisashi Soda, Yukiyoshi Moriuchi, Masao Tomonaga, Yasushi Miyazaki
Organizer
The 3rd JSH International Symposium 2012 in Kawagoe
Place of Presentation
川越市(埼玉)
Year and Date
2012-05-26
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[Presentation] Allogeneic StemCell Transplantation at the Primary Induction Failure or after the 1st Relapse Dose not Conquer Poor Prognosis of AML with FLT3-ITD2012
Author(s)
Rika Kihara, Hitoshi Kiyoi, Shigeaki Ohtake, Shuichi Miyawaki, Yasushi Miyazaki, Norio Asou, Toru Sakura, Yukiyasu Ozawa, Noriko Usui, Heiwa Kanamori, Toru Kiguchi, Kiyotoshi Imai, Naokuni Uike, Fumihiro Kimura, Tomoki Naoe
Organizer
The 3rd JSH International Symposium 2012 in Kawagoe
Place of Presentation
川越市(埼玉)
Year and Date
2012-05-26