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2012 Fiscal Year Final Research Report

Pathogenesis of autoantibodies against prothrombin

Research Project

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Project/Area Number 22591074
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionHokkaido University

Principal Investigator

ATSUMI Tatsuya  北海道大学, 大学院・医学研究科, 教授 (20301905)

Project Period (FY) 2010 – 2012
Keywords抗リン脂質抗体 / 血栓症 / 自己免疫 / ループスアンチコアグラント
Research Abstract

The aim of this research was to clarify how autoantibodies against prothrombin, one of the major markers of antiphosholipid syndrome(APS), are related with thrombophilia in patients with APS. The antiprothrombin antibodies affected endothelial cells or monocytes, leading to the over-expression of procoagulant substances. In this procedure, ribopholin II, precent on cell surface, was likely to be involved as a receptor ofprothrombin molecule.

  • Research Products

    (27 results)

All 2013 2012 2010 Other

All Journal Article (23 results) (of which Peer Reviewed: 23 results) Presentation (1 results) Book (3 results)

  • [Journal Article] Contrast-enhanced whole body joint MR Imaging in rheumatoid patients on tumour necrosis factor-alpha agents: a pilot study to evaluate novel scoring system for MR synovitis2013

    • Author(s)
      Kamishima T, Kato M, Atsumi T, Koike T, Onodera Y, Terae S
    • Journal Title

      ClinExp Rheumatol

      Volume: 31(1) Pages: 154

    • Peer Reviewed
  • [Journal Article] Overexpression of TNF-α-converting enzyme in fibroblasts augments dermal fibrosis after inflammation2013

    • Author(s)
      Fukaya S, Matsui Y, Tomaru U, Kawakami A, Sogo S, Bohgaki T, Atsumi T, Koike T, Kasahara M, Ishizu A
    • Journal Title

      Lab Invest

      Volume: 93(1) Pages: 72-80

    • DOI

      DOI:10.1038/labinvest.2012.153

    • Peer Reviewed
  • [Journal Article] Phospholipid scramblase 1 expression is enhanced in patients with antiphospholipid syndrome2013

    • Author(s)
      Amengual O, Atsumi T, Oku K, Suzuki E, Horita T, Yasuda S, Koike T
    • Journal Title

      Mod Rheumatol

      Volume: 23(1) Pages: 81-8

    • DOI

      DOI:10.1007/s10165-012-0642-9

    • Peer Reviewed
  • [Journal Article] Elevation of KL-6 serum levels in clinical trials of tumor necrosis factor inhibitors in patients with rheumatoid arthritis: a report from the Japan College of Rheumatology Ad Hoc Committee for Safety of Biological DMARDs2013

    • Author(s)
      Harigai M, Takamura A, Atsumi T, Dohi M, Hirata S, Kameda H, Nagasawa H, Seto Y, Koike T, Miyasaka N
    • Journal Title

      Mod Rheumatol

      Volume: 23(2) Pages: 284-96

    • DOI

      DOI:10.1007/s10165-012-0657-2

    • Peer Reviewed
  • [Journal Article] Amerged presentation of clinical and radiographic data using probability plots in a clinical trial, the JESMR study2013

    • Author(s)
      Kameda H, Kanbe K, Sato E, Ueki Y, Saito K, Nagaoka S, Hidaka T, Atsumi T, Tsukano M, Kasama T, Shiozawa S, Tanaka Y, Yamanaka H, Takeuchi T
    • Journal Title

      Ann Rheum Dis

      Volume: 72 Pages: 310-2

    • DOI

      DOI:10.1136/annrheumdis-2012-201804

    • Peer Reviewed
  • [Journal Article] Predominant prevalence of arterial thrombosis in Japanese patients with antiphospholipid syndrome2012

    • Author(s)
      Fujieda Y, Atsumi T, Amengual O, Odani T, Otomo K, Kato M, Oku K, Kon Y, Horita T, Yasuda S, Koike T
    • Journal Title

      Lupus

      Volume: 21(14) Pages: 1506-14

    • DOI

      DOI:10.1177/0961203312458469

    • Peer Reviewed
  • [Journal Article] Up-regulated expression of HLA-DRB5 transcripts and high frequency of the HLA-DRB5*01:05 allele in scleroderma patients with interstitial lung disease2012

    • Author(s)
      Odani T, Yasuda S, Ota Y, Fujieda Y, Kon Y, Horita T, Kawaguchi Y, Atsumi T, Yamanaka H, Koike T
    • Journal Title

      Rheumatology(Oxford)

      Volume: 51(10) Pages: 1765-74

    • Peer Reviewed
  • [Journal Article] Factor XI is a substrate for oxidoreductases: enhanced activation of reduced FXI and its role in antiphospholipid syndrome thrombosis.2012

    • Author(s)
      Giannakopoulod B, Gao L, Qi M, Wong JW, Yu DM, Vlachoyiannopoulos PG, Moutsopoulos HM, Atsumi T, Koike T, Hogg P, Qi JC, Krilis SA
    • Journal Title

      JAutoimmun

      Volume: 39(3) Pages: 121-9

    • DOI

      DOI:10.1016/j.jaut.2012.05.005

    • Peer Reviewed
  • [Journal Article] Drug retention rates and relevant riskfactors for drug discontinuation due to adverse events in rheumatoid arthritis patients receiving anticytokine therapy with different target molecules2012

    • Author(s)
      Sakai R, Tanaka M, Nanki T, Watanabe K, Yamazaki H, Koike R, Nagasawa H, Amano K, Saito K,Tanaka Y, Ito S, Sumida T, Ihata A, Ishigatsubo Y, Atsumi T, Koike T, Nakajima A, Tamura N, Fujii T, Dobashi H, Tohma S, Sugihara T, Ueki Y, Hashiramoto A, Kawakami A, Hagino N, Miyasaka N, Harigai M
    • Journal Title

      Ann Rheum Dis

      Volume: 71(11) Pages: 1820-6

    • DOI

      DOI:10.1136/annrheumdis-2011-200838

    • Peer Reviewed
  • [Journal Article] Time-dependent increased risk for serious infection from continuous use of tumor necrosis factor antagonists over three years in patients with rheumatoid arthritis2012

    • Author(s)
      Sakai R, Komano Y, Tanaka M, Nanki T, Koike R, Nagasawa H, Amano K, Nakajima A, Atsumi T, Koike T, Ihata A, Ishigatsubo Y, Saito K,Tanaka Y, Ito S, Sumida T, Tohma S,Tamura N, Fujii T, Sugihara T, Kawakami A, Hagino N, Ueki Y, Hashiramoto A, Nagasawa K,Miyasaka N, Harigai M
    • Journal Title

      Arthritis Care Res

      Volume: 64(8) Pages: 1125-34

    • DOI

      DOI:10.1136/annrheumdis-2011-200838

    • Peer Reviewed
  • [Journal Article] Impaired expression of Act1mRNA in B cells of patients with Sjogren's syndrome2012

    • Author(s)
      Nakagawa Y, Kataoka H, Kurita T, Nakagawa H, Yasuda S, Horita T, Atsumi T, Koike T
    • Journal Title

      Nihon Rinsho Meneki Gakkai Kaishi

      Volume: 35(1) Pages: 75-80

    • Peer Reviewed
  • [Journal Article] A case of catastrophic antiphospholipid antibody syndrome complicated with systemic lupus erythematosus, double positive for anti-cardiolipin/β(2) glycoprotein I and anti-phosphatidylserine/prothrombin autoantibodies.2012

    • Author(s)
      Hirakawa E, Saito K, Hirata S, Atsumi T, Koike T, Tanaka Y
    • Journal Title

      Mod Rheumatol

      Volume: 22(5) Pages: 769-73

    • DOI

      DOI:.10.1007/s10165-011-0563-z

    • Peer Reviewed
  • [Journal Article] The efficacy of antiphospholipid score for the diagnosis of antiphospholipid syndrome and its predictive value for thrombotic events2012

    • Author(s)
      Otomo K, Atsumi T, Amengual O, Fujieda Y, Kato M, Oku K, Horita T, Yasuda S, Koike T
    • Journal Title

      Arthritis Rheum

      Volume: 64(2) Pages: 504-12

    • DOI

      DOI:10.1002/art.33340.

    • Peer Reviewed
  • [Journal Article] Positive synovial vascularity in patients with low disease activity indicates smouldering inflammation leading to joint damage in rheumatoid arthritis: time-integrated joint inflammation estimated by synovial vascularity in each finger joint2012

    • Author(s)
      Fukae J, Isobe M, Kitano A, Henmi M, Sakamoto F, Narita A, Ito T, Mitsuzaki A, Shimizu M, Tanimura K, Matsuhashi M, Kamishima T, Atsumi T, Koike T.
    • Journal Title

      Rheumatology

      Volume: 52(3) Pages: 523-8

    • DOI

      DOI:10.1093/rheumatology/kes

    • Peer Reviewed
  • [Journal Article] Risk modification by CYP1A1 and GSTM1 polymorphisms in the association of cigarette smoking and systemic lupus erythematosus in a Japanese population2012

    • Author(s)
      Kiyohara C, Washio M, Horiuchi T, Asami T, Ide S, Atsumi T, Kobashi G, Takahashi H, Tada Y
    • Journal Title

      Scand J Rheumatol

      Volume: 41 Pages: 103-9

    • DOI

      DOI:10.3109/03009742.2011.608194

    • Peer Reviewed
  • [Journal Article] Thrombotic microangiopathy due to multiple autoantibodies related to antiphospholipid syndrome2012

    • Author(s)
      Noda S, Ogura M, Tsutsumi A, Udagawa T, Kamei K, Matsuoka K, Kitamura H, Atsumi T, Ito S
    • Journal Title

      Pediatr Nephrol

      Volume: 4 Pages: 681-5

    • DOI

      DOI:10.1007/s00467-011-2085-5

    • Peer Reviewed
  • [Journal Article] Severity-based treatment for Japanese patients with MPO-ANCA-associated vasculitis: the JMAAV study2012

    • Author(s)
      Ozaki S, Atsumi T, Hayashi T, Ishizu A, Kobayashi S, Kumagai S, Kurihara Y,Kurokawa MS, Makino H, Nagafuchi H, Nakabayashi K, Nishimoto N, Suka M, Tomino Y, Yamada H, Yamagata K, Yoshida M, Yumura W
    • Journal Title

      Mod Rheumatol

      Volume: 22 Pages: 394-404

    • DOI

      DOI:10.1007/s10165-011-0525-5

    • Peer Reviewed
  • [Journal Article] Management of resolved hepatitis B in patients with low anti-hepatitis B surface titer who undergo aggressive immunosuppressive therapy: reply to the letter by Mori.2012

    • Author(s)
      Kato M, Atsumi T
    • Journal Title

      J Rheumatol

      Volume: 39 Pages: 1293-4

    • DOI

      DOI:10.3899/jrheum.120117

    • Peer Reviewed
  • [Journal Article] A Genome-Wide Association Study Identified AFF1 as a Susceptibility Locus for Systemic Lupus Eyrthematosus in Japanese2012

    • Author(s)
      Okada Y, Shimane K, Kochi Y, Tahira T, Suzuki A, Higasa K, Takahashi A, Horita T, Atsumi T, Ishii T, Okamoto A, Fujio K, Hirakata M, Amano H, Kondo Y, Ito S, Takada K, Mimori A, Saito K, Kamachi M, Kawaguchi Y, Ikari K, Mohammed OW, Matsuda K, Terao C, Ohmura K, Myouzen K, Hosono N, Tsunoda T, Nishimoto N, Mimori T, Matsuda F, Tanaka Y, Sumida T, Yamanaka H, Takasaki Y, Koike T, Horiuchi T, Hayashi K, Kubo M, Kamatani N, Yamada R, Nakamura Y, Yamamoto K
    • Journal Title

      PLoS Genet

      Volume: 8 Pages: e1002455

    • DOI

      DOI:10.1371/journal.pgen.1002455

    • Peer Reviewed
  • [Journal Article] Cigarette Smoking, Alcohol Consumption, and Risk of Systemic Lupus Erythematosus: A Case-control Study in a JapanesePopulation2012

    • Author(s)
      Kiyohara C, Washio M, Horiuchi T, Asami T, Ide S, Atsumi T, Kobashi G, Tada Y, Takahashi H
    • Journal Title

      J Rheumatol

      Volume: 39 Pages: 1363-70

    • DOI

      DOI:10.3899/jrheum.111609

    • Peer Reviewed
  • [Journal Article] Pathophysiology of thrombosis and pregnancy morbidity in the antiphospholipid syndrome2012

    • Author(s)
      Oku K, Amengual O, Atsumi T
    • Journal Title

      Eur J Clin Invest

      Volume: 42 Pages: 1126-35

    • DOI

      DOI:10.1111/j.1365-2362.2012.02697.x

    • Peer Reviewed
  • [Journal Article] Essential role of the p38 mitogen-activated protein kinase pathway in the tissue factor gene expression by the phosphatidylserine-dependent antiprothrombin antibody.

    • Author(s)
      Oku K, Amengual O, Zigon P, Horita T, Yasuda S, Atsumi T
    • Journal Title

      Rheumatol

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] The involvement of CD36 in the monocyte activation by antiphospholipid antibodies

    • Author(s)
      Kato M, Atsumi T, Oku K, Amengual O, Nakagawa H, Fujieda1 Y, Otomo K, Horita T, Yasuda S, Koike T
    • Journal Title

      Lupus

      Volume: (in press)

    • Peer Reviewed
  • [Presentation] Phosphatidylserine dependent antiprothrombin antibodiessignificance and international standardization.2010

    • Author(s)
      Atsumi T.
    • Organizer
      58th Annual Scientific andStandardization Committee Meeting
    • Place of Presentation
      International Society on Thrombosis andHaemostasis, Liverpool
    • Year and Date
      20100618-30
  • [Book] 抗リン脂質抗体症候群2013

    • Author(s)
      渥美達也
    • Total Pages
      875-6
    • Publisher
      南江堂
  • [Book] 全身性エリテマトーデス2013

    • Author(s)
      坊垣暁之、渥美達也
    • Total Pages
      224-5
    • Publisher
      羊土社
  • [Book] 抗リン脂質抗体症候群2012

    • Author(s)
      藤枝雄一郎、渥美達也
    • Total Pages
      453-7
    • Publisher
      中外医学社

URL: 

Published: 2014-08-29  

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