2012 Fiscal Year Final Research Report
The role of Notch on rheumatoid arthritis
| Project/Area Number |
22591085
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
膠原病・アレルギー・感染症内科学
|
|---|
| Research Institution | Juntendo University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | Notch / 関節リウマチ |
|---|
| Research Abstract |
We revealed that Notch2/Delta-like 1 (Dll1) axis promotedosteoclastogenesis but Notch1/Jagged1 axis suppressed it. Actually, blockade of Dll1 suppressed osteoclastogenesis and bone loss in the affected joints of a mouse arthritis model as well as a mouse osteoporosis model while no effect was observed on normal mouse.Therefore, blockade of Dll1 could be a novel target for the treatment of RA.
|
