2012 Fiscal Year Final Research Report
Novel pathologic factors in vasculitis - comprehensive analysis by peptidomics and their clinical significance
| Project/Area Number |
22591087
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
OZAKI Shoichi 聖マリアンナ医科大学, 医学部, 教授 (00231233)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Tomohiro 聖マリアンナ医科大学, 医学部, 教授 (80233807)
KUROKAWA Manae 聖マリアンナ医科大学, 医学部, 准教授 (90301598)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ANCA 関連血管炎 / 前向き臨床試験 / 病態関連ペプチド / プロテオミクス / アポリポ蛋白 A-1 |
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| Research Abstract |
Peptidomic analysis revealed 7 peptides that significantly increased or decreased in sera of patients with microscopic polyangiitis (MPA) before treatment. Among them, a peptide of 1523 kDa was identified as a C-terminal 13-mer peptide of apolipoprotein A-I, hence named AC13. AC13 was found to increase only in sera of patients with active MPA and decrease after treatment. AC13 stimulated endothelial cell lines to secrete significant levels of IL-6 and IL-8. Thus, AC13 seemed to play a pathological role in MPA and serve as a novel biomarker.
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