A classification and identification of the asthmatic disease-inducedCD4 T cell subset with costimulatory molecule marker

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591098
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Juntendo University
• Principal Investigator: AKIBA Hisaya 順天堂大学, 医学研究科, 准教授 (60338316)
• Project Period (FY): 2010 – 2012
• Keywords: 補助シグナル分子 / Th1/Th2 / 喘息モデルマウス / 関節炎モデルマウス

Research Abstract

We revealed that antigen-specific CD4 T cells were separated into CD27+and CD27-populations in the lymph node from OVA-immunized DO11.10/Rag-2-/-mice.The CD27+CD4 T cells produced a high level of IFN-・, representing Th1 cells. In contrast, CD27-CD4 T cells produced high levels of IL-4, IL-5, and IL-13, representing Th2 cells.Eosinophil infiltration and Th2 cytokine production in the lung and the population of CD27-Th2 cells was significantly reduced by the anti-CD70 mAb treatment. These results indicated an important role for CD27 in the development of pathogenic Th2 cells in a murine model of allergic lung inflammation.

Research Products

• [Journal Article] Blockade of CD70-CD27 Interaction Inhibits Induction of Allergic Lung Inflammation in Mice (2012)
  • Author(s): Makino F, Ito J, Abe Y, Harada N, Kamachi F, Yagita H, Takahashi K, Okumura K, Akiba H
  • Journal Title: American journal of respiratory cell and molecular biology Volume: 47 Pages: 298-305
  • DOI: DOI:10.1165/rcmb.2011-0354OC
  • Peer Reviewed
• [Journal Article] Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1 (2012)
  • Author(s): Chiba S, Baghdadi M, Akiba H, Yoshiyama H, Kinoshita I, Dosaka-Akita H, Fujioka Y, Ohba Y, Gorman JV, Colgan JD, Hirashima M, Uede T, Takaoka A, Yagita H, Jinushi M
  • Journal Title: Nature immunology Volume: 13 Pages: 832-842
  • DOI: DOI:10.1038/ni.2376
  • Peer Reviewed
• [Journal Article] Galectin-9 and T cell immunoglobulin mucin-3 pathway is a therapeutic target for type 1 diabetes (2012)
  • Author(s): Kanzaki M, Wada J, Sugiyama K, Nakatsuka A, Teshigawara S, Murakami K, Inoue K, Terami T, Katayama A, Eguchi J, Akiba H, Yagita H, Makino H
  • Journal Title: Endocrinology Volume: 153 Pages: 612-620
  • DOI: DOI:10.1210/en.2011-1579
  • Peer Reviewed
• [Journal Article] Expression pattern changes and function of RANKL during mouse lymph node microarchitecture development (2012)
  • Author(s): Sugiyama M, Nakato G, Jinnohara T, Akiba H, Okumura K, Ohno H, Yoshida H
  • Journal Title: International immunology Volume: 24 Pages: 369-378
  • DOI: DOI:10.1093/intimm/dxs002
  • Peer Reviewed
• [Journal Article] Antibodies against B7-DC with differential binding properties exert opposite effects (2012)
  • Author(s): Ritprajak P, Hashiguchi M, Akiba H, Yagita H, Okumura K, Azuma M
  • Journal Title: Hybridoma Volume: 31 Pages: 40-47
  • DOI: DOI:10.1089/hyb.2011.0087
  • Peer Reviewed
• [Journal Article] EndogenousTim-1 promotes T-cell responses and cell-mediated injury in experimental crescentic glomerulonephritis (2012)
  • Author(s): ozaki Y, Nikolic-Paterson DJ, Snelgrove SL, Akiba H, Yagita H,Holdsworth SR, Kitching AR
  • Journal Title: Kidney international Volume: 81 Pages: 844-855
  • DOI: DOI:10.1038/ki.2011.424
  • Peer Reviewed
• [Journal Article] TIM-1 signaling in B cells regulates antibody production (2012)
  • Author(s): Ma J, Usui Y, Takeda K, Harada N, Yagita H, Okumura K, Akiba H
  • Journal Title: iochem Biophys Res Commun Volume: 406 Pages: 223-228
  • DOI: DOI:10.1016/j.bbrc.2011.02.021
  • Peer Reviewed
• [Journal Article] Anti-TIM-2 monoclonal antibody exacerbates collagen-induced arthritis by stimulating B cells (2011)
  • Author(s): Kawamoto T, Abe Y, Ito J, Makino F, Kojima Y, Usui Y, Ma J, Morimoto S, Yagita H, Okumura K, Takasaki Y, Akiba H
  • Journal Title: Arthritis Res Ther Volume: 13 Pages: R47
  • DOI: DOI:10.1186/ar3288
  • Peer Reviewed
• [Journal Article] The TIM-1:TIM-4 pathway enhances renal ischemia-reperfusion injury (2011)
  • Author(s): Rong S, Park JK, Kirsch T, Yagita H, Akiba H, Boenisch O, Haller H, Najafian N, Habicht A
  • Journal Title: J Am Soc Nephrol Volume: 22 Pages: 484-495
  • DOI: DOI:10.1681/ASN.2010030321
  • Peer Reviewed
• [Journal Article] Tim-1 promotes cisplatin nephrotoxicity (2011)
  • Author(s): Nozaki Y, Nikolic-Paterson DJ, Yagita H, Akiba H, Holdsworth SR, Kitching AR
  • Journal Title: Am J Physiol Renal Physiol Volume: 301 Pages: F1098-1104
  • DOI: DOI:10.1152/ajprenal.00193.2011
  • Peer Reviewed
• [Journal Article] Anti-TIM3 antibody promotes T cell IFN-gamma-mediated antitumor immunity and suppresses established tumors (2011)
  • Author(s): Ngiow SF, von Scheidt B, Akiba H, Yagita H, Teng MW, Smyth MJ
  • Journal Title: Cancer Res Volume: 71 Pages: 3540-3551
  • DOI: DOI:10.1158/0008-5472.CAN-11-0096
  • Peer Reviewed
• [Journal Article] Wound-induced TGF-γ1 and TGF-γ2 enhance airway epithelial repair via HB-EGF and TGF-α. (2011)
  • Author(s): Ito J, Harada N, Nagashima O, Makino F, Usui Y, Yagita H, Okumura K, Dorscheid DR, Atsuta R, Akiba H, Takahashi K
  • Journal Title: Biochem Biophys Res Commun Volume: 412 Pages: 109-114
  • DOI: DOI:10.1016/j.bbrc.2011.07.054
  • Peer Reviewed
• [Journal Article] Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice (2011)
  • Author(s): Ding Q, Yeung M, Camirand G, Zeng Q, Akiba H, Yagita H, Chalasani G, Sayegh MH, Najafian N, Rothstein DM
  • Journal Title: J Clin Invest Volume: 121 Pages: 3645-3656
  • DOI: DOI:10.1172/JCI46274
  • Peer Reviewed
• [Journal Article] TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury (2010)
  • Author(s): Yamanishi Y, Kitaura J, Izawa K, Kaitani A, Komeno Y, Nakamura M, Yamazaki S, Enomoto Y, Oki T, Akiba H, Abe T, Komori T, Morikawa Y, Kiyonari H, Takai T, Okumura K, Kitamura T.
  • Journal Title: J Exp Med Volume: 207 Pages: 1501-1511
  • DOI: DOI:10.1084/jem.20090581
  • Peer Reviewed
• [Journal Article] Expression and function of inducible costimulator on peripheral blood CD4+T cells in Behcet's patients with uveitis: a new activity marker? (2010)
  • Author(s): Usui Y, Takeuchi M, Yamakawa N, Takeuchi A, Kezuka T, Ma J, Matsuda R, Okunuki Y, Akiba H, Goto H
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 51 Pages: 5099-5104
  • DOI: DOI:10.1167/iovs.10-5286
  • Peer Reviewed
• [Journal Article] TIM-3 determines severity of liver ischemia/reperfusion injury in mice in a TLR4-dependent manner (2010)
  • Author(s): Uchida Y, Ke B, Freitas MC, Yagita H,Akiba H, Busuttil RW, Najafian N, Kupiec-Weglinski JW
  • Journal Title: Gastroenterology Volume: 139 Pages: 2195-2206
  • DOI: DOI:10.1053/j.gastro.2010.07.003
  • Peer Reviewed
• [Journal Article] The emerging role of TIM-1 in the mechanism of liver ischemia and reperfusion injury in the mouse (2010)
  • Author(s): Uchida Y, Ke B, Freitas MC, Ji H, Zhao D, Benjamin ER, Najafian N, Yagita H, Akiba H, Busuttil RW, Kupiec-Weglinski JW
  • Journal Title: Hepatolog Volume: 51 Pages: 1363-1372
  • DOI: DOI:10.1002/hep.23442
  • Peer Reviewed
• [Journal Article] Premature terminal exhaustion of Friend virus-specific effector CD8+T cells by rapid induction of multiple inhibitory receptors (2010)
  • Author(s): Takamura S, Tsuji-Kawahara S, Yagita H, Akiba H, Sakamoto M, Chikaishi T, Kato M, Miyazawa M
  • Journal Title: J Immunol Volume: 184 Pages: 4696-4707
  • DOI: DOI:10.4049/jimmunol.0903478
  • Peer Reviewed
• [Journal Article] Contribution of B7RP-1/ICOS co-stimulation to lethal acute GVHD (2010)
  • Author(s): Fujimura J, Takeda K, Kaduka Y, Saito M, Akiba H, Yagita H, Yamashiro Y, Shimizu T, Okumura K
  • Journal Title: Pediatr Transplant Volume: 14 Pages: 540-548
  • DOI: DOI:10.1111/j.1399-3046.2009.01279.x
  • Peer Reviewed
• [Journal Article] IM-3: a novel regulatory molecule of alloimmune activation (2010)
  • Author(s): Boenisch O, D'Addio F, Watanabe T, Elyaman W, Magee CN, Yeung MY, Padera RF, Rodig SJ, Murayama T, Tanaka K, Yuan X, Ueno T, Jurisch A, Mfarrej B, Akiba H, Yagita H, Najafian N
  • Journal Title: J Immunol Volume: 185 Pages: 5806-5819
  • DOI: DOI:10.4049/jimmunol.0903435
  • Peer Reviewed
• [Remarks] ホームページ情報
  • URL: http://www.juntendo.ac.jp/graduate/laboratory/labo/meneki/home.html