2012 Fiscal Year Final Research Report
Molecular basis of febrile seizure and new treatment
| Project/Area Number |
22591130
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Okayama University |
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Principal Investigator |
INOUE Takushi 岡山大学, 岡山大学病院, 医員 (80572990)
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| Co-Investigator(Kenkyū-buntansha) |
OHMORI Iori 岡山大学, 大学院・医歯薬学総合研究科, 助教 (20403488)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 熱性けいれん / 電位依存性ナトリウムチャネル / SCN1A遺伝子 / 二酸化炭素吸入療法 / 呼吸性アルカローシス |
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| Research Abstract |
The aim of this study was to assess the anticonvulsant effect of carbon dioxide (CO_2) on Scn1a mutation-related febrile seizures. We examined physiological changes in the blood gas levels after the induction of hyperthermia-induced seizures (HISs), which were associated with the Scn1a missense mutation. The Scn1a mutant rats demonstrated a higher HISs susceptibility associated with respiratory alkalosis than the WT rats. Inhalation of 10% CO_2 shortened the seizure duration. Blood gas analysis after the inhalation of 10% CO_2 demonstrated an elevated pCO_2 level and respiratory acidosis. Inhalation of 10% CO_2 demonstrated a potent and fast-acting anticonvulsant effect against HISs.
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