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2012 Fiscal Year Final Research Report

Quality assessment of cryopreserved-mesenchymal stem cells derived from umbilical cord blood

Research Project

  • PDF
Project/Area Number 22591150
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionTohoku University

Principal Investigator

MINEGISHI Masayoshi  東北大学, 病院, 准教授 (20211592)

Co-Investigator(Kenkyū-buntansha) TSUCHIYA Sigeru  東北大学, 大学院・医学系研究科, 教授 (30124605)
ONUMA Masaei  東北大学, 病院, 医員 (70436111)
Project Period (FY) 2010 – 2012
Keywords間葉系幹細胞 / 臍帯血 / 凍結保存
Research Abstract

In this study, we isolated 5 clones of mesenchymal stem cells from human umbilical cord blood. Four clones yielded MSC with more than 1,000-fold expansion capacity after cryopreservation as well as before cryopreservation. Chromosomal analysis showed an abnormal karyotype in one clone after freezing. Further studies are needed to investigate the risk of prolonged culture periods and cryopreservation for the safety of MSC cell therapy.

  • Research Products

    (3 results)

All 2012 2011

All Journal Article (3 results)

  • [Journal Article] Development of a multi-step leukemogenesis model of MLL-rearranged leukemia using humanized mice2012

    • Author(s)
      Moriya K, Suzuki M, Watanabe Y, Takahashi T, Aoki Y, Uchiyama T, Kumaki S, Sasahara Y, Minegishi M, Kure S, Tsuchiya S, Sugamura K, and Ishii N.
    • Journal Title

      PLoS ONE

      Volume: 7(6) Pages: e37892

    • DOI

      doi:10.1371/journal.pone.0037892

  • [Journal Article] Successful cord blood transplantation with reduced-intensity conditioning for childhood cerebral X-linked adrenoleukodystrophy at advanced and early stages2012

    • Author(s)
      Niizuma H, Uematsu M, Sakamoto O, Uchiyama T, Horino S, Onuma M, Matsuhashi T, Rikiishi T, Sasahara Y, Minegishi M, Tsuchiya S.
    • Journal Title

      Pediatr Transplant

      Volume: 16(2) Pages: E63-70

    • DOI

      doi:10.1111/j.1399-3046.2011.01539.x.

  • [Journal Article] Quality assessment of umbilical cord blood units at the time of transplantation2011

    • Author(s)
      Kudo Y, Minegishi M, Seki O, Takahashi H, Suzuki A, Narita A, Sato Y, Abe M, Ishioka N, Harigae H, Tsuchiya S.
    • Journal Title

      Int J Hematol

      Volume: 93(5) Pages: 645-51

    • DOI

      doi:10.1007/s12185-011-0830-y.

URL: 

Published: 2014-08-29  

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