2012 Fiscal Year Final Research Report
Study of pathogenesis of chronic active EB virus infection and its treatment strategy.
| Project/Area Number |
22591182
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kochi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
DAIBATA Masanori 高知大学, 教育研究部医療学系, 教授 (50263976)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 感染症学 / ウイルス学 / 微生物学 |
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| Research Abstract |
Epstein-Barr virus (EBV) genotypes can be distinguished based on gene sequence differences in EBV nuclear antigens 2 and 3C, and the BZLF1 promoter zone (Zp). EBV subtypes and BZLF1 Zp variants were examined in Japanese patients with chronic active EBV infection (CAEBV), infectious mononucleosis (IM), and EBV-associated hemophagocytic lymphohistiocytosis (EBV-HLH). EBV genotype in IM, CAEBV, and EBV-HLH all belonged to type 1. However, sequencing analysis of BZLF1 Zp found three polymorphic Zp variants. This is the first evidence that the EBV variant distribution in Japanese patients resembles that found in other Asian patients. Twenty-nine CAEBV-associated cellular genes were previously identified by microarray analysis of in vitro cultured cell lines derived from patients with CAEBV. In this study, we also investigated the expression levels of these cellular genes in the three EBV-related disorders including CAEBV, IM, and EBV-HLH, using real-time RT-PCR analysis.
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Research Products
(37 results)
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[Journal Article] Hemophagocytic lymphohistiocytosis after hematopoietic stem cell transplantation in children: a nationwide survey in Japan.2012
Author(s)
Asano T, Kogawa K, Morimoto A, Ishida Y, Suzuki N, Ohga S, Kudo K, Ohta S, Wakiguchi H, Tabuchi K, Kato S, Ishii E.
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Journal Title
Pediatric Blood & Cancer.
Volume: 59
Pages: 110-114
DOI
Peer Reviewed
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[Journal Article] Epstein-Barr virus load for early detection of lymphoproliferative disorder in pediatric renal transplant recipients.2011
Author(s)
Ishihara M, Tanaka E, Sato T, Chikamoto H, Hisano M, Akioka Y, DohnoS, Maeda A, Hattori M,Wakiguchi H, Fujieda M
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Journal Title
Clinical Nephrology
Volume: 76
Pages: 40-48
Peer Reviewed
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[Journal Article] Asymptomatic high Epstein-Barr viral load carriage in pediatric renal transplant recipients.2011
Author(s)
Tanaka E, Sato T, Ishihara M, Tsutsumi Y, Hisano M, Chikamoto H, Akioka Y, Dohno S, Maeda A, Hattori M, Wakiguchi H, Fujieda M.
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Journal Title
Pediatr Transplantation
Volume: 15
Pages: 306-313
DOI
Peer Reviewed
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[Journal Article] Four cases of postrenal renal failure induced by renal stone associated with rotavirus infection.2010
Author(s)
Morita T, Ashida A, Fujieda M, Hayashi A, Maeda A, Ohta K, Shimizu M, Sekine T, Igarashi T, Tamai H, Wakiguchi H.
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Journal Title
Clinical Nephrology
Volume: 73
Pages: 398-402
Peer Reviewed
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