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2012 Fiscal Year Final Research Report

Study of pathogenesis of chronic active EB virus infection and its treatment strategy.

Research Project

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Project/Area Number 22591182
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionKochi University

Principal Investigator

WAKIGUCHI Hiroshi  高知大学, 学長 (10116519)

Co-Investigator(Kenkyū-buntansha) DAIBATA Masanori  高知大学, 教育研究部医療学系, 教授 (50263976)
Project Period (FY) 2010 – 2012
Keywords感染症学 / ウイルス学 / 微生物学
Research Abstract

Epstein-Barr virus (EBV) genotypes can be distinguished based on gene sequence differences in EBV nuclear antigens 2 and 3C, and the BZLF1 promoter zone (Zp). EBV subtypes and BZLF1 Zp variants were examined in Japanese patients with chronic active EBV infection (CAEBV), infectious mononucleosis (IM), and EBV-associated hemophagocytic lymphohistiocytosis (EBV-HLH). EBV genotype in IM, CAEBV, and EBV-HLH all belonged to type 1. However, sequencing analysis of BZLF1 Zp found three polymorphic Zp variants. This is the first evidence that the EBV variant distribution in Japanese patients resembles that found in other Asian patients. Twenty-nine CAEBV-associated cellular genes were previously identified by microarray analysis of in vitro cultured cell lines derived from patients with CAEBV. In this study, we also investigated the expression levels of these cellular genes in the three EBV-related disorders including CAEBV, IM, and EBV-HLH, using real-time RT-PCR analysis.

  • Research Products

    (37 results)

All 2013 2012 2011 2010 Other

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (17 results) Book (3 results) Remarks (1 results)

  • [Journal Article] Characterization of Epstein-Barr virus (EBV) BZLF1 gene promoter variants and comparison of cellular gene expression profiles in Japanese patients with infectious mononucleosis, chronic active EBV infection, and EBV-associated hemophagocytic lymphohistioc2012

    • Author(s)
      Imajoh M, Hashida Y, Murakami M, Maeda A, Sato T, Fujieda M, Wakiguchi H, Daibata M.
    • Journal Title

      Journal of Medical Virology

      Volume: 84 Pages: 940-946

    • DOI

      doi: 10.1002/jmv.23299

    • Peer Reviewed
  • [Journal Article] Hemophagocytic lymphohistiocytosis after hematopoietic stem cell transplantation in children: a nationwide survey in Japan.2012

    • Author(s)
      Asano T, Kogawa K, Morimoto A, Ishida Y, Suzuki N, Ohga S, Kudo K, Ohta S, Wakiguchi H, Tabuchi K, Kato S, Ishii E.
    • Journal Title

      Pediatric Blood & Cancer.

      Volume: 59 Pages: 110-114

    • DOI

      doi: 10.1002/pbc.23384

    • Peer Reviewed
  • [Journal Article] Effect of single-dose oralmizoribine pulse therapy twice per week for frequently relapsing steroid-dependent nephrotic syndrome.2012

    • Author(s)
      Fujieda M, Ishihara M, Morita T, Hayashi A, Okada S, Ohta T, Sakano T, Wakiguchi H.
    • Journal Title

      ClinicalNephrology.

      Volume: 78 Pages: 40-46

    • Peer Reviewed
  • [Journal Article] A novel anti-peroxiredoxin autoantibodyinpatients with Kawasaki disease.2012

    • Author(s)
      Fujieda M, Karasawa R, Takasugi H,Yamamoto M, Kataoka K, Yudoh K, KatoT, Ozaki S, Wakiguchi H.
    • Journal Title

      Microbiology andImmunology.

      Volume: 56 Pages: 56-61

    • DOI

      doi: 10.1111/j.1348-0421.2011.00393.x

    • Peer Reviewed
  • [Journal Article] Neonatal lupus erythematosus in identical twins, showing transient bullous lesions.2011

    • Author(s)
      Nakajima K, Wakiguchi H, Kodama H,Sano S.l
    • Journal Title

      Pediatric Dermatology

      Volume: 28 Pages: 397-400

    • DOI

      doi:10.1111/j.1525-1470.2010.01197.x

    • Peer Reviewed
  • [Journal Article] Epstein-Barr virus load for early detection of lymphoproliferative disorder in pediatric renal transplant recipients.2011

    • Author(s)
      Ishihara M, Tanaka E, Sato T, Chikamoto H, Hisano M, Akioka Y, DohnoS, Maeda A, Hattori M,Wakiguchi H, Fujieda M
    • Journal Title

      Clinical Nephrology

      Volume: 76 Pages: 40-48

    • Peer Reviewed
  • [Journal Article] Autoimmune lymphoproliferative syndrome mimicking chronic active Epstein-Barr virus infection.2011

    • Author(s)
      Nomura K, Kanegane H, OtsuboK, Wakiguchi H, Noda Y, Kasahara Y, Miyawaki T
    • Journal Title

      International Journal of Hematology.

      Volume: 93 Pages: 760-764

    • DOI

      doi: 10.1007/s12185-011-0877-9

    • Peer Reviewed
  • [Journal Article] Conditional VHL gene deletion activates a local NO-VEGF axis in a balanced manner reinforcing resistance to endothelium-targeted glomerulonephropathy.2011

    • Author(s)
      Morita T, Kakinuma Y, Kurabayashi A, Fujieda M, Sato T, Shuin T, Furihata M, Wakiguchi H.
    • Journal Title

      Nephrology Dialysis Transplantation.

      Volume: 26 Pages: 4023-4031

    • DOI

      doi: 10.1093/ndt/gfr176.

    • Peer Reviewed
  • [Journal Article] Asymptomatic high Epstein-Barr viral load carriage in pediatric renal transplant recipients.2011

    • Author(s)
      Tanaka E, Sato T, Ishihara M, Tsutsumi Y, Hisano M, Chikamoto H, Akioka Y, Dohno S, Maeda A, Hattori M, Wakiguchi H, Fujieda M.
    • Journal Title

      Pediatr Transplantation

      Volume: 15 Pages: 306-313

    • DOI

      doi:10.1111/j.1399-3046.2010.01465.x

    • Peer Reviewed
  • [Journal Article] Effect of pravastatin on cisplatin-induced nephrotoxicity in rats.2011

    • Author(s)
      Fujieda M, Morita T, Naruse K, Hayashi Y, Ishihara M, Yokoyama T, Toma T, Ohta K, Wakiguchi H.
    • Journal Title

      Human & Experimental Toxicology.

      Volume: 30 Pages: 603-615

    • DOI

      doi: 10.1177/0960327110376551

    • Peer Reviewed
  • [Journal Article] A case of pseudohomozygous type II hyperlipoproteinemia in early infancy2011

    • Author(s)
      Tamaki W, Fujieda M, Maeda M, Hosokawa T, Morita H, Asami T, Wakiguchi H.
    • Journal Title

      Pediatrics International.

      Volume: 53 Pages: 110-113

    • DOI

      doi: 10.1111/j.1442-200X.2010.03237.x.

    • Peer Reviewed
  • [Journal Article] Neutrophil infiltration and oxidant-production in human atherosclerotic carotid plaques.2011

    • Author(s)
      Hosokawa T, Kumon Y, Kobayashi T, Enzan H, Nishioka Y, Yuri K, Wakiguchi H, Sugiura T.
    • Journal Title

      Histology and Histopathology.

      Volume: 26 Pages: 1-11

    • Peer Reviewed
  • [Journal Article] Pediatric Hirayama disease2010

    • Author(s)
      Hosokawa T, Fujieda M, Wakiguchi H, Oosaki Y.
    • Journal Title

      Pediatric Neurology

      Volume: 43 Pages: 151-153

    • DOI

      doi: 10.1016/j.pediatrneurol.2010.03.015

    • Peer Reviewed
  • [Journal Article] Four cases of postrenal renal failure induced by renal stone associated with rotavirus infection.2010

    • Author(s)
      Morita T, Ashida A, Fujieda M, Hayashi A, Maeda A, Ohta K, Shimizu M, Sekine T, Igarashi T, Tamai H, Wakiguchi H.
    • Journal Title

      Clinical Nephrology

      Volume: 73 Pages: 398-402

    • Peer Reviewed
  • [Journal Article] Isolation and characterization of a novel Staphylococcus aureus bacteriophage, phiMR25, and its therapeutic potential.2010

    • Author(s)
      Hoshiba H, Uchiyama J, Kato S, Ujihara T, Muraoka A, Daibata M, Wakiguchi H, Matsuzaki S.
    • Journal Title

      Archives of Virology

      Volume: 155 Pages: 545-552

    • DOI

      doi: 10.1007/s00705-010-0623-2

    • Peer Reviewed
  • [Journal Article] Diagnosis of infectious mononucleosis caused by Epstein-Barr virus in infants.2010

    • Author(s)
      Dohno S, Maeda A, Ishiura Y, Sato T, Fujieda M, Wakiguchi H.
    • Journal Title

      Pediatrics International.

      Volume: 52 Pages: 536-540

    • DOI

      doi: 10.1111/j.1442-200X.2010.03087.x.

    • Peer Reviewed
  • [Presentation] 管出血性大腸菌O-157による溶血性尿毒症症候群の経過中に急性膵炎を合併した1例.2012

    • Author(s)
      佐藤哲也, 脇口宏, 他
    • Organizer
      第44回日本小児感染症学会
    • Place of Presentation
      北九州国際会議場(北九州市)
    • Year and Date
      2012-11-25
  • [Presentation] 全国多施設共同サーベイランスによる小児侵襲性細菌感染症の臨床疫学的解析~Hibおよび肺炎球菌ワクチン導入のインパクト~.2012

    • Author(s)
      菅秀, 脇口宏, 他.
    • Organizer
      第44回日本小児感染症学会, 第44回日本小児感染症学会
    • Place of Presentation
      北九州国際会議場(北九州市)
    • Year and Date
      2012-11-24
  • [Presentation] 胆汁うっ滞が遷延し肝生検で肝内胆管減少症と診断された超低出生体重児の1例.2012

    • Author(s)
      荒木まり子, 脇口宏, 他.
    • Organizer
      第39回日本小児栄養消化器肝臓学会
    • Place of Presentation
      新梅田シティ梅田スカイビル(大阪市)
    • Year and Date
      2012-07-14
  • [Presentation] 高度な高ビリルビン血症を呈さなかったが後に核黄疸と診断された極低出生体重児の1例.2012

    • Author(s)
      松下憲司, 脇口宏, 他
    • Organizer
      第48回日本周産期・新生児医学会学術集会
    • Place of Presentation
      大宮ソニックシティ(大宮市)
    • Year and Date
      2012-07-10
  • [Presentation] ミトコンドリア呼吸鎖の酵素活性低下により診断されたミトコンドリア心筋症の姉妹例.2012

    • Author(s)
      山本雅樹, 脇口宏, 他.
    • Organizer
      第48回日本小児循環器学会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2012-07-06
  • [Presentation] 生後1ヵ月で両側腎石灰化のみられた遠位尿細管性アシドーシスの男児例.2012

    • Author(s)
      石原正行, 脇口宏, 他.
    • Organizer
      第47回日本小児腎臓病学会学術集会
    • Place of Presentation
      都市センターホテル(東京都)
    • Year and Date
      2012-06-30
  • [Presentation] 開窓Fontan術後進行する腎不全のため10歳台で腹膜透析を導入したAlport症候群疑いの女児例.2012

    • Author(s)
      森田拓, 脇口宏, 他.
    • Organizer
      第47回日本小児腎臓病学会学術集会
    • Place of Presentation
      都市センターホテル(東京都)
    • Year and Date
      2012-06-29
  • [Presentation] 高知県の小児救急医療体制の現状2012

    • Author(s)
      吉川清志, 脇口宏, 他.
    • Organizer
      第23回日本小児科医会総会フォーラム
    • Place of Presentation
      ホテルさっぽろ芸文館(札幌市)
    • Year and Date
      2012-06-10
  • [Presentation] 後天的なVHL遺伝子の不活化によるNO-VEGF系活性化は、血管内皮細胞において糸球体腎症への抵抗を増強する.2012

    • Author(s)
      森田拓, 脇口宏, 他.
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2012-06-02
  • [Presentation] MRA、脳波所見が診断に有用であった家族性片麻痺性片頭痛の13歳男児例.2012

    • Author(s)
      細川卓利, 脇口宏, 他.
    • Organizer
      第54回日本小児神経学会総会
    • Place of Presentation
      ロイトン札幌(札幌市)
    • Year and Date
      2012-05-17
  • [Presentation] 幼児期に言語発達遅滞を認めた小児の就学時の診断について.2012

    • Author(s)
      満田直美, 脇口宏, 他
    • Organizer
      第54回日本小児神経学会総会
    • Place of Presentation
      ロイトン札幌(札幌市)
    • Year and Date
      2012-05-17
  • [Presentation] 川崎病における抗Peroxiredoxin2(Prx2)抗体の存在と意義2012

    • Author(s)
      藤枝幹也, 脇口宏, 他.
    • Organizer
      第115回日本小児科学会
    • Place of Presentation
      福岡サンパレスホテル&ホール(福岡市)
    • Year and Date
      2012-04-22
  • [Presentation] X-linked Myotubular myopathyの一例.2012

    • Author(s)
      大石拓, 脇口宏, 他
    • Organizer
      第115回日本小児科学会
    • Place of Presentation
      福岡サンパレスホテル&ホール(福岡市)
    • Year and Date
      2012-04-21
  • [Presentation] 移植15カ月後、髄液中にLGLを認めたEBV関連NKリンパ腫の1例.2011

    • Author(s)
      堂野純孝, 脇口宏, 他
    • Organizer
      第53回日本小児血液・がん学会学術集会
    • Place of Presentation
      ベイシア文化ホール(前橋市)
    • Year and Date
      2011-11-26
  • [Presentation] 再生不良性貧血発症時にAML1/EBV-1キメラ遺伝子が陽性であったAA-MDSの1例.2010

    • Author(s)
      菊地広朗, 脇口宏, 他
    • Organizer
      第52回日本小児血液学会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2010-12-17
  • [Presentation] Bウイルス関連疾患における感染細胞の同定に関する検討.2010

    • Author(s)
      佐藤哲也, 脇口宏, 他
    • Organizer
      第42回日本小児感染症学会
    • Place of Presentation
      仙台国際センター(仙台市)
    • Year and Date
      2010-11-27
  • [Presentation] 低γ-グロブリン血症とBリンパ球減少に慢性活動性EBV感染症を合併した1女児例2010

    • Author(s)
      佐藤哲也, 脇口宏, 他
    • Organizer
      第113回日本小児科学会
    • Place of Presentation
      盛岡市文化ホール(盛岡市)
    • Year and Date
      2010-04-24
  • [Book] 小児用ワクチンUpdate, ワクチンに関する基礎知識, 医学のあゆみ2013

    • Author(s)
      佐藤哲也,脇口宏, 他
    • Total Pages
      11-14
    • Publisher
      医歯薬出版社
  • [Book] Epstein-Barrウイルスのさまざまな病態.新編ウイルスの今日的意味2012

    • Author(s)
      前田明彦, 脇口宏, 他
    • Total Pages
      178-188
    • Publisher
      医薬ジャーナル社
  • [Book] EBウイルス感染症の様々な病態2012

    • Author(s)
      脇口宏
    • Total Pages
      71-78
    • Publisher
      日本医事新報社
  • [Remarks] 高知大学医学部

    • URL

      http://www.kochi-ms.ac.jp/

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Published: 2014-08-29  

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