The pathophysiology of NLR ligand-induced coronary arteritis like Kawasaki disease

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591183
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Kyushu University
• Principal Investigator: NISHIO Hisanori 九州大学, 大学病院, 学術研究員 (00507783)
• Co-Investigator(Kenkyū-buntansha): YAMAMURA Kenichiro 九州大学, 大学院・医学研究院, 助教 (30532858) ; NAGATA Hazumu 九州大学, 大学院・医学研究院, 助教 (20570790)
• Project Period (FY): 2010 – 2012
• Keywords: 小児循環器学 / 川崎病 / 冠動脈炎

Research Abstract

In NLR ligand-induced coronary arteritis model like Kawasaki disease, the lesion of coronary artery showed higher expression of various cytokine’s and chemokine’s genesthan those of other blood vessels, suggesting that intrinsic factors of each vascular tissue were important on this site-specific vascular inflammation. Furthermore, the frequency and severity of this coronary arteritis were enhanced by priming of various bacterial component. This model could explain the site-specific vascular inflammation and diversity of etiology in Kawasaki disease.

Research Products

• [Journal Article] (2011)
  • Author(s): Nishio H, et al
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 31(5) Pages: 1093-9
  • Peer Reviewed
• [Presentation] Nod1 ligand-induced coronary arteritis is enhanced by various bacterial components (2012)
  • Author(s): Nishio H et al
  • Organizer: Pediatric Academic Societies
  • Place of Presentation: Boston, America
  • Year and Date: 20120428-0501
• [Presentation] A novel role of Nod1 in the vascular inflammation (2012)
  • Author(s): Hara T, Nishio H
  • Organizer: World Immune Regulation Meeting
  • Place of Presentation: Davos, Switzerland
  • Year and Date: 20120313-16
• [Presentation] Nod1 ligands induce coronary arteritis (2011)
  • Author(s): Hara T, Nishio H et al
  • Organizer: 6th European meeting for vascular biology & medicine
  • Place of Presentation: Krakow, Poland
  • Year and Date: 20110921-24
• [Presentation] Establishment of a coronary arteritis murine model by oral administration of pure innate immune ligands (2011)
  • Author(s): Hara T, Nishio H et al
  • Organizer: 10th world congress on inflammation
  • Place of Presentation: Paris, France
  • Year and Date: 20110625-29
• [Presentation] NLR ligands induce site-specific vascular inflammation (2011)
  • Author(s): Nishio H et al
  • Organizer: 2011 Pediatric Academic Societies
  • Place of Presentation: Denver, America
  • Year and Date: 20110430-0503
• [Presentation] Novel coronary arteritis murine model induced by pure innate immune ligands (2011)
  • Author(s): Nishio H et al
  • Organizer: 22nd Fukuoka international symposium on pediatric/maternal-child health research
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2011-09-03