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2012 Fiscal Year Final Research Report

Research on mechanism of progression from vasculitis of Kawasaki disease to sclerotic lesion

Research Project

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Project/Area Number 22591188
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

KAWAI Yoko  京都府立医科大学, 医学部附属病院, 専攻医 (60405248)

Co-Investigator(Kenkyū-buntansha) HAMAOKA Kenji  京都府立医科大学, 医学研究科, 教授 (60189602)
TOIYAMA Kentaro  京都府立医科大学, 医学研究科, 助教 (00433285)
Project Period (FY) 2010 – 2012
Keywords小児循環器学 / 川崎病 / 酸化ストレス / 血小板 / 動脈硬化 / 血管障害
Research Abstract

Inflammation, oxidative stress and vascular endothelial disorder related deeply the onset of vascular disorder and arteriosclerosis. They initiate production of various cytokines and platelet activation, thereby progress disease condition.We examined platelet activation and oxidative stress in acute Kawasaki disease. Oxidativestress and inflammatory markers in IVIG-responder group immediately decreased by IVIG treatment. On the other hand, antioxidant marker of IVIG-nonresponder group in pre-treatment was significantly lower than that of healthy control and IVIG-responder group, and oxidative stress and inflammatory markers maintained high value.Platelet was activated for more six months from the onset of Kawasaki disease. This study showed the evaluation of oxidative stress and activated platelets are useful and have clinical significance.

  • Research Products

    (1 results)

All 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] Spontaneous Thrombotic Obstruction of Aneurysmal Coronary Arteriovenous Fistula2012

    • Author(s)
      Yoko Kawai,Kenji Hamaoka
    • Journal Title

      Pediatr Cardiol

    • Peer Reviewed

URL: 

Published: 2014-08-29  

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