2012 Fiscal Year Final Research Report
Searching for allergic contact dermatitis biomarker through microarray and proteomic analyses to establish diagnostic technique
| Project/Area Number |
22591233
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Fujita Health University |
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Principal Investigator |
YAGAMI Akiko 藤田保健衛生大学, 医学部, 准教授 (90367699)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Hirohisa 独立行政法人国立成育医療研究センター, 副所長 (40130166)
MATSUNAGA Kayoko 藤田保健衛生大学, 医学部, 教授 (80131192)
HAYASHI Nobuhiro 東京工業大学, 生命理工学部, 准教授 (80267955)
OBOKI Keisuke 独立行政法人国立成育医療研究センター, 免疫アレルギー研究部, 研究員 (80415108)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 診断バイオマーカー / 染毛剤 / para-phenylenediamine |
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| Research Abstract |
Six patients with allergic contact dermatitis due to para-phenylenediamine were studied. With the consent from these patients, blood, hair root tissue and buccal mucosa samples were taken to extract total RNA using reagents such as RNA stabilizer (RNAlaterR). Microarray and Proteomic analyses, which were conducted finally, found no significant difference from control group, and specific biomarker was not identified. However, we believe this study meaningful in that above mentioned methods were tried, for the first time, to detect biomarker of allergic contact dermatitis due to hair dye.
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[Journal Article] 接触皮膚炎ガイドライン2009
Author(s)
高山かおる,横関博雄,松永佳世子,片山一朗,相場節也,伊藤正俊,池澤善郎,足立厚子,戸倉新樹,夏秋優,古川福実,矢上晶子,幸野健,乾重樹,池澤優子,相原道子
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Journal Title
日皮会誌
Volume: 11(9)
Pages: 1757-1793
URL
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