2012 Fiscal Year Final Research Report
Induction of TSLP by environmental and self factors associated with atopic dermatitis
| Project/Area Number |
22591251
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Juntendo University |
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Principal Investigator |
TAKAI Toshiro 順天堂大学, 大学院・医学研究科, 准教授 (70338375)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 皮膚炎症 / 再生医学 / アトピー性皮膚炎 |
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| Research Abstract |
We analyzed induction of TSLP in human primary keratinocytes. Staphylococcus aurous, which is known to colonize in skin of atopic dermatitis patients, bacterial flagellin, and atopic cytokine milieu, induced TSLP. We found that detection of the long form TSLP gene expression was a sensitive assay. The study identified some novel environmental and self-factors that contribute to the TSLP induction and regulation.
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[Journal Article] IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation2013
Author(s)
Kamijo S, Takeda H, Tokura T, Suzuki M, Inui K, Hara M, Matsuda H, Matsuda A, Oboki K, Ohno T, Saito H, Nakae S, Sudo K, Suto H, Ichikawa S, Ogawa H, Okumura K, Takai T
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Journal Title
J Immunol
Volume: 190
Pages: 4489-99
Peer Reviewed
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[Journal Article] Immunization of rabbits with nematode Ascaris lumbricoides antigens induces antibodies cross-reactive to house dust mite Dermatophagoides farinae antigens2013
Author(s)
Nakazawa T, Khan AF, Yasueda H, Saito A, Fukutomi Y, Takai T, Zaman K, Yunus M, Takeuchi H, Iwata T, Akiyama K
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Journal Title
Biosc Biotechnol Biochem
Volume: 77
Pages: 145-150
Peer Reviewed
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[Journal Article] Extracellular double-stranded RNA induces TSLP via an endosomal acidification- and NF-kB-dependent pathway in human keratinocytes2012
Author(s)
Vu AT, Chen X, Xie Y, Kamijo S, Ushio H, Kawasaki J, Hara M, Ikeda S, Okumura K, Ogawa H, Takai T
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Journal Title
J Invest Dermatol
Volume: 131
Pages: 2205-2212
Peer Reviewed
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[Journal Article] Prevention of allergic asthma by vaccination with transgenic rice seed expressing mite allergen: induction of allergen-specific oral tolerance without bystander suppression2011
Author(s)
Suzuki K, Kaminuma O, Yang L, Takai T, Mori A, Umezu-Goto M, Ohtomo T, Ohmachi Y, Noda Y, Hirose S, Okumura K, Ogawa H, Takada K, Hirasawa M, Hiroi T, Takaiwa F
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Journal Title
Plant Biotechnol J
Volume: 9
Pages: 982-990
Peer Reviewed
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[Journal Article] Staphylococcus aureus membrane and diacylated lipopeptide induce thymic stromal lymphopoietin in keratinocytes via the Toll-like receptor 2-Toll-like receptor 6 pathway2010
Author(s)
Vu AT, Baba T, Chen X, Le TA, Kinoshita H, Xie Y, Kamijo S, Hiramatsu K, Ikeda S, Ogawa H, Okumura K, Takai T
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Journal Title
J Allergy Clin Immunol
Volume: 126
Pages: 985-993.e1-3
Peer Reviewed
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[Journal Article] Staphylococcus aureus extracellular protease causes epidermal barrier dysfunction2010
Author(s)
Hirasawa Y, Takai T, Nakamura T, Mitsuishi K, Gunawan H, Suto H,Ogawa T, Wang XL, Ikeda S, Okumura K, Ogawa H
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Journal Title
J Invest Dermatol
Volume: 130
Pages: 614-617
Peer Reviewed
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[Journal Article] Proinflammatory response in human keratinocytes stimulated with ligands for TLR2, TLR1, and TLR62010
Author(s)
Vu AT, Takai T, Le TA, Kinoshita H, Kamijo S, Hara M, Wang XL, Ogawa T, Ikeda S, Ogawa H, Okumura K
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Journal Title
Juntendo Medical Journal
Volume: 56
Pages: 50-55
Peer Reviewed
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