Frontal lobe abnormalities in alcoholics: a multimodal molecular imaging study

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591258
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: IWATA Yasuhide 浜松医科大学, 医学部附属病院, 講師 (10285025)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Kazuhiko 弘前大学, 医学部, 教授 (80263911) ; SUZUKI Katsuaki 浜松医科大学, 医学部, 准教授 (00285040) ; UEKI Takatoshi 浜松医科大学, 医学部, 准教授 (60317328) ; TAKEBAYASHI Kiyokazu 浜松医科大学, 医学部, 講師 (50397428)
• Project Period (FY): 2010 – 2012
• Keywords: 中毒性精神障害 / アルコール依存 / 分子イメージング

Research Abstract

Evidence suggests that the degeneration of neurons, abnormal axon travelling, and activation of microglia may underpin the frontal lobe dysfunction in alcohol dependence. In this study, in order to clarify the details of the frontal lobe injury in living alcoholism patients, we recruited 10 patients with alcoholism and 10 healthy comparison subjects, and examinedtheir brain with the diffusion tensor imaging, molecular imaging for activated microglia, and glucose metabolism by positron emission tomography. We also examined the relevance of the frontal lobe function to be evaluated by cognitive psychology testing battery. Asa result, we found no significant difference between the control and patients group in any of neuroimaging findings, suggesting that further evaluations with more participants will be required.

Research Products

• [Journal Article] Microglial activation in young adults with autism spectrum disorder (2013)
  • Author(s): Suzuki K, Sugihara G, Ouchi Y, Nakamura K, Futatsubashi M, Takebayashi K, Yoshihara Y, Omata K, Matsumoto K, Tsuchiya KJ, Iwata Y, Tsujii M, Sugiyama T, Mori N
  • Journal Title: JAMA Psychiatry Volume: 70 Pages: 49-5
  • DOI: DOI:10.1001/jamapsychiatry.2013.272
• [Journal Article] Effects of brain amyloid deposition and reduced glucose metabolism on the default mode of brain function in normal aging (2011)
  • Author(s): Kikuchi M, Hirosawa T, Yokokura M, Yagi S, Mori N, Yoshikawa E, Yoshihara Y, Sugihara G, Takebayashi K, Iwata Y, Suzuki K, Nakamura K, Ueki T, Minabe Y, Ouchi Y
  • Journal Title: Neurosci Volume: 31 Pages: 11193-9
  • DOI: DOI:10.1523/JNEUROSCI.2535-11.2011.
• [Journal Article] Reduced acetylcholinesterase activity in the fusiform gyrus in adults with autism spectrum disorders (2011)
  • Author(s): Suzuki K, Sugihara G, Ouchi Y, Nakamura K, Tsujii M, Futatsubashi M, Iwata Y, Tsuchiya KJ, Matsumoto K, Takebayashi K, Wakuda T, Yoshihara Y, Suda S, Kikuchi M, Takei N, Sugiyama T, Irie T, Mori N
  • Journal Title: Arch Gen Psychiatry Volume: 68 Pages: 306-13
  • DOI: DOI:10.1001/archgenpsychiatry.2011.4
• [Journal Article] Replication study of Japanese cohorts supports the role of STX1A in autism susceptibility. (2011)
  • Author(s): Nakamura K, Iwata Y, Anitha A, Miyachi T, Toyota T, Yamada S, Tsujii M, Tsuchiya KJ, Iwayama Y, Yamada K, Hattori E, Matsuzaki H, Matsumoto K, Suzuki K, Suda S, Takebayashi K, Takei N, Ichikawa H, Sugiyama T, Yoshikawa T, Mori N
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 35 Pages: 454-8
  • DOI: DOI:10.1016/j.pnpbp.2010.11.033
• [Journal Article] In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimer's disease (2011)
  • Author(s): Yok oku r a M, Mo r i N, Yag i S, Yos h ik awa E, Kikuchi M, Yoshihara Y, Wakuda T, Sugihara G, Takebayashi K, Suda S, Iwata Y, Ueki T, Tsuchiya KJ, Suzuki K, Nakamura K, Ouchi Y
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 38 Pages: 343-51
  • DOI: DOI:10.1007/s00259-010-1612-0
• [Journal Article] Failure to confirm genetic association of the FXYD6 gene with schizophrenia: the Japanese population and meta-analysis (2011)
  • Author(s): Iwata Y, Yamada K, Iwayama Y, Anitha A, Thanseem I, Toyota T, Hattori E, Ohnishi T, Maekawa M, Nakamura K, Suzuki K, Matsuzaki H, Tsuchiya KJ, Suda S, Sugihara G, Takebayashi K, Yamamoto S, Iwata K, Mori N, Yoshikawa T
  • Journal Title: Am J Med Genet B Neuro- psychiatr Genet Volume: 153 Pages: 1221-7
  • DOI: DOI: 10.1002/ajmg.b.31095
• [Journal Article] Reduced expression of apolipoprotein E receptor type 2 in peripheral blood lymphocytes from patients with major depressive disorder (2010)
  • Author(s): Suzuki K, Iwata Y, Matsuzaki H, Anitha A, Suda S, Iwata K, Shinmura C, Kameno Y, Tsuchiya KJ, Nakamura K, Takei N, Mori N
  • Journal Title: Prog Neuropsycho- pharmacol Biol Psychiatry Volume: 34 Pages: 1007-10
  • DOI: DOI:10.1016/j.pnpbp.2010.05.014