2012 Fiscal Year Final Research Report
Approach to the rare variation hypothesis of the psychiatric disorderby a next generation type ultra high-speed sequencer
| Project/Area Number |
22591263
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OZAWA Hiroki 長崎大学, 医歯薬学総合研究科, 教授 (50260766)
IMAMURA Akira 長崎大学, 医歯薬学総合研究科, 准教授 (40325642)
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIURA Kouichirou 長崎大学, 医歯薬学総合研究科, 教授 (00304931)
MISHIMA Hiroyuki 長崎大学, 医歯薬学総合研究科, 助教 (10513319)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 遺伝子 / マイクロアレイ / 精神疾患 / 稀少変異仮説 / ホモ接合マッピング / Runs of homozygosity |
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| Research Abstract |
We performed the molecular analysis of psychiatric diseases including schizophrenia and bipolar disorders. In this analysis, several novel loci were detected. Possible loci were chromosomes 1, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 16, 17,19, 20, and 21. Interestingly, just one locus had been reported. Their region concluded more than 200 genes. Also, we show that SCZ is highly heterogeneous.
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Research Products
(15 results)
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[Journal Article] Missense mutations in the DNA-binding/dimerization domain of NFIX cause Sotos-like features2012
Author(s)
Yoneda Y, Saitsu H, Touyama M, Makita Y, Miyamoto A, Hamada K, Kurotaki N, Tomita H, Nishiyama K, Tsurusaki Y, Doi H, Miyake N, Ogata K, Naritomi K, Matsumoto N
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Journal Title
J Hum Genet
Volume: 57(3)
Pages: 207-11
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[Journal Article] Mutations in PRRT2 responsible for paroxysmal kinesigenic dyskinesias also cause benign familial infantile convulsions2012
Author(s)
Ono S, Yoshiura KI, Kinoshita A, Kikuchi T, Nakane Y, Kato N, Sadamatsu M, Konishi T, Nagamitsu S, Matsuura M, Yasuda A, Komine M, Kanai K, Inoue T, Osamura T, Saito K, Hirose S, Koide H, Tomita H, Ozawa H, Niikawa N, Kurotaki N
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Journal Title
J Hum Genet
Volume: 57(5)
Pages: 338-41
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[Journal Article] Mutations in PRRT2 responsible for paroxysmal kinesigenic dyskinesias also cause benign familial infantile convulsions2012
Author(s)
Ono S, Yoshiura K, Kinoshita A, Kikuchi T, Nakane Y, Kato N, Sadamatsu M, Konishi T, Nagamitsu S, Matsuura M, Yasuda A, Komine M, Kanai K, Inoue T, Osamura T, Saito K, Hirose S, Koide H, Tomita H, Ozawa H, Niikawa N, Kurotaki N
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Journal Title
J Hum Genet, Jun
Volume: 57(6)
Pages: 399
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