2012 Fiscal Year Final Research Report
potential of sorafenib in inhibition of multi-step carcinogenesis for hepatocellular carcinoma
| Project/Area Number |
22591325
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
TAKEHARA Yasuo 浜松医科大学, 医学部附属病院, 教授 (70188217)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIE Michio 浜松医科大学, 実験実習機器センター, 技術専門員 (90397373)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 画像診断学 |
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| Research Abstract |
The purpose of the study was to assess if per-oral administration of sorafenib can inhibit muti-step carcinogenesis for chemically induced hepatocellular carcinoma (HCC) in rat model. Contrast enhanced MRI using Gd-EOB-DTPA and immunohistochemically stainedliver specimen were performed to evaluate the induction of the hypervascular HCC. As a result, an earlier administration of the sorafenib resulted in less developments of hypervascular HCC by inhibiting vascular inductions to the dysplastic nodules.
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