Development of CT study protocol for comprehensive assessment of coronary plaque volume and myocardial flow reserve using 320MDCT

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591326
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Mie University
• Principal Investigator: KITAGAWA Kakuya 三重大学, 医学部附属病院, 助教 (50378353)
• Co-Investigator(Kenkyū-buntansha): SAKUMA Hajime 三重大学, 大学院・医学系研究科, 教授 (60205797) ; TAKEDA Kan 三重大学, 医学部附属病院, 病院長 (70106988) ; NAKAYAMA Ryouhei 三重大学, 医学部附属病院, 助教 (20402688)
• Project Period (FY): 2010 – 2012
• Keywords: エックス線 / CT

Research Abstract

We have developed a 320-slice MDCT protocol consisting of resting-state coronary CT angiography and pharmacologic-stress myocardial perfusion CT. However, its diagnostic performance was not high enough to be clinically considered when fractional flow reserve and MRI were used as gold standard. We, then, changed the CT platform to dual source CT with much higher temporal resolution, and developed a protocol consisting of coronary CT angiography, stress dynamic myocardial perfusion and CT delayed enhancement. This new protocol showed high diagnostic accuracy of 92% when compared with invasive coronary angiography and stress myocardial perfusion MRI.

Research Products

• [Journal Article] インナービジョン (2013)
  • Author(s): 永澤直樹、北川覚也
  • Volume: 28
  • Pages: 11-14
• [Journal Article] (2012)
  • Author(s): 北川覚也
  • Journal Title: 映像情報メディカル Volume: 44 Pages: 127-129
• [Presentation] The blood-to-myocardium transfer coefficient, K1 (2012)
  • Author(s): Kitagawa K, Ishida M, Nagata M, Ito T, Nakayama R, Sakuma H
  • Organizer: determined by Patlak plot analysis showed close correlation with MBF determined by dedicated perfusion CT software
  • Place of Presentation: Baltimore
  • Year and Date: 2012-07-21
• [Presentation] Dynamic perfusion CT: Usefulness of respiratory monitoring device for precise localization of the LV myocardium (2012)
  • Author(s): Kitagawa K, Nagasawa N, Ito T, Nagata M, Ishida M, Sakuma H
  • Organizer: Society of Cardiovascular Computed Tomography
  • Place of Presentation: Baltimore
  • Year and Date: 2012-07-20
• [Presentation] Stress Contrast Enhanced CT for Diagnosing Myocardial Ischemia: Comparison with Stress Myocardial Perfusion MRI and Fractional Flow Reserve. (2012)
  • Author(s): Kitagawa K, Nakamori S, Nagata M, Ishida M, Nakajima H, Sakuma H
  • Organizer: Asian Society of Cardiovascular
  • Place of Presentation: Bangkok
  • Year and Date: 2012-06-09
• [Presentation] Image Quality and Radiation Exposure of Low-dose Dual-source Dynamic CT StressMyocardial Perfusion Imaging (2012)
  • Author(s): Fujita M, Kitagawa K, Ito T, ShiraishiY, Kurobe Y, Nagata M, Ishida M, Sakuma H
  • Organizer: A Randomized Study Comparing 80-kVp/370-mAs and100-kVp/300-mAsEuropean Congress of Radiology
  • Place of Presentation: Vienna
  • Year and Date: 2012-03-09
• [Presentation] Myocardial CT delayed enhancement using dual-source CT and shuttle mode scan: comparison with conventional axial scan and MR delayed enhancement (2012)
  • Author(s): Kurobe Y, Kitagawa K, Ito T, Shiraishi Y, Fujita M, Nagata M, Ishida M, Sakuma H
  • Organizer: European Congress of Radiology
  • Place of Presentation: Vienna
  • Year and Date: 2012-03-09
• [Presentation] Comprehensive cardiac CT examination incorporating stress CT perfusion and rest CT angiography: Is rest CT angiography always required (2011)
  • Author(s): Nakamori S, Kitagawa K, Nagata M, Ishida M, Nakajima H, Onishi K, Nakamura M, Ito M, Sakuma H
  • Organizer: Society of Cardiovascular Computed Tomography
  • Place of Presentation: Denver
  • Year and Date: 2011-07-16