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2012 Fiscal Year Final Research Report

Evaluation of liver function and fibrosis using SPIO-MRI

Research Project

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Project/Area Number 22591342
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionKyushu University

Principal Investigator

NISHIE Akihiro  九州大学, 大学病院, 助教 (20457427)

Co-Investigator(Kenkyū-buntansha) ASAYAMA Yoshiki  九州大学, 大学病院, 助教 (40380414)
USHIJIMA Yasuhiro  九州大学, 医学研究院, 助教 (40432934)
TAKAYAMA Yukihisa  九州大学, 医学研究院, 助教 (60546563)
FUJITA Nobuhiro  九州大学, 医学研究院, 助教 (30610612)
HONDA Hiroshi  九州大学, 医学研究院, 教授 (90145433)
ISHIGAMI Kousei  九州大学, 大学病院, 助教 (10403916)
KAKIHARA Daisuke  九州大学, 医学研究院, 助教 (80529818)
NAKAYAMA Tomohiro  国立国際医療研究センター病院, 放射線診 療部, 医師 (70419571)
Project Period (FY) 2010 – 2012
KeywordsMRI / T2*強調画像 / T2強調画像 / SPIO / Kupffer細胞 / Heme oxygenase-1
Research Abstract

R2* value, which represents iron deposition of the liver parenchyma, and ΔR2* and ΔR2 values, which represent differences in R2* and R2 values of the liver parenchyma before and after administration of SPIO, showed significant correlation with parameters obtained on Technetium-99m galactosyl serum albumin scintigraphy. However, they were no significant correlation with liver fibrosis and necro-inflammatory activity. Because Kupffer cells play an important role on the early stage of liver fibrogenesis, these cells may rather activate and increase phagocytotic function compared with normal condition and advanced stage of liver fibrosis.

  • Research Products

    (3 results)

All 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (1 results)

  • [Journal Article] Quantitative analysis of liver function using superparamagnetic iron oxide- and Gd-EOB-DTPA-enhanced MRI: Comparison with Technetium-99m galactosyl serum albumin scintigraphy2012

    • Author(s)
      Nishie A, Ushijima Y, Tajima T, Asayama Y, Ishigami K, Kakihara D, Nakayama T, Takayama Y, Okamoto D, Abe K, Obara M,Yoshimitsu K, Honda H
    • Journal Title

      Eur J Radiol

      Volume: 81(6) Pages: 1100-4

    • Peer Reviewed
  • [Journal Article] MR prediction of liver fibrosis using a liver-specific contrast agent: Superparamagnetic iron oxide versus Gd-EOB-DTPA2012

    • Author(s)
      Nishie A, Asayama Y, Ishigami K, Tajima T, Kakihara D, Nakayama T, Takayama Y, Okamoto D, Taketomi A, Shirabe K, Fujita N, Obara M, Yoshimitsu K, Honda H
    • Journal Title

      J Magn Reson Imaging

      Volume: 36(3) Pages: 664-71

    • Peer Reviewed
  • [Presentation] シンポジウム 肝胆膵領域の機能画像・新しい撮像法2012

    • Author(s)
      九州大学 臨床放射線科学 西江昭弘
    • Organizer
      第71回日本医学放射線学会総会
    • Place of Presentation
      横浜
    • Year and Date
      20120412-15

URL: 

Published: 2014-08-29  

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