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2012 Fiscal Year Final Research Report

MR-cellular density imaging for evaluation of early response to chemotherapy.

Research Project

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Project/Area Number 22591363
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionAichi Cancer Center Research Institute

Principal Investigator

MATSUSHIMA Shigeru  愛知県がんセンター(研究所), 遺伝子医療研究部, 研究員 (70444297)

Co-Investigator(Renkei-kenkyūsha) KINOSADA Yasutomi  岐阜大学, 大学院・医学系研究科, 教授 (50161526)
ERA Seiichi  岐阜大学, 大学院・医学系研究科, 教授 (30152002)
Project Period (FY) 2010 – 2012
Keywords癌 / 早期治療効果判定 / 分子画像 / 細胞密度画像 / 機能画像 / 磁気共鳴 / 磁化移動効果
Research Abstract

The aim of this study was to evaluate an early prediction of response to chemotherapy by MR-cellular density imaging. We developed " contrast enhance ratio in hepatocellular (CERH) imaging, Uptake CERH imaging " and " Equivalent cross-relaxation rate (ECR) imaging " as MR-cellular density imaging. Uptake CERH images can visualize heterogeneous and partial uptake liver function. ECR images can be applied early prediction of response to chemotherapy according to decrease of cellular density.

  • Research Products

    (18 results)

All 2013 2012 2011 2010 0

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (13 results)

  • [Journal Article] Evaluation of parotid gland function using equivalent cross-relaxation rate imaging applied magnetization transfer effect.2012

    • Author(s)
      H. Shimizu, S. Matsushima, Y. Kinosada, H. Miyamura, T. Kubota, H. Osaki, M. Nakayama, M. Yoshimoto, T. Kodaira.
    • Journal Title

      Journal of Radiation Research

      Volume: 53 Pages: 138-144

    • Peer Reviewed
  • [Journal Article] Cellular Imaging Using Equivalent Cross-Relaxation Rate Technique in Rabbit VX-2 Tumor Model.2011

    • Author(s)
      H. Nishiofuku, S. Matsushima, O. Taguchi, Y. Inaba, H. Yamaura, Y. Sato, T. Tanaka and K. Kichikawa.
    • Journal Title

      Cancer Informatics

      Volume: 10 Pages: 227-232

    • Peer Reviewed
  • [Journal Article] Comparative intermolecular cross-relaxation studies of human hemoglobin in red blood cells and bovine serum albumin in solution.2011

    • Author(s)
      S. Era, M. Sogami, N. Uyesaka, M. Murakami, S. Matsushima and Y. Kinosada.
    • Journal Title

      NMR Biomed.

      Volume: 24 Pages: 483-491

    • Peer Reviewed
  • [Journal Article] Comparative ^1H NMR studies of saturation transfer in copolymer gels and mouse lenses.2010

    • Author(s)
      K. Nakamura, M. Sogami, S. Era, S. Matsushima, Y. Kinosa.
    • Journal Title

      NMR Biomed

      Volume: 23(6) Pages: 584-591

    • Peer Reviewed
  • [Journal Article] Cell-Weighted Imaging for Malignant Lymphoma Using Equivalent Cross-Relaxation Rate Imaging-Initial Experience.2010

    • Author(s)
      H. Nishiofuku, S. Matsushima, Y. Inaba, H, Yamaura, Y. Sato, Y. Morishima, K. Kichikawa.
    • Journal Title

      Korean Journal of Radiology

      Volume: 11(3) Pages: 327-332

    • Peer Reviewed
  • [Presentation] Evaluated the correlation of uptake contrast enhanced ratio in hepato-biliary phase imaging to existing liver function tests.2013

    • Author(s)
      S. Matsushima, Y. Sato, H. Yamaura, M. Kato, D. Inoue, Y. Kinosada, S. Era, K. Takahashi, Y. Inaba
    • Organizer
      2013 European Congress of Radiology.
    • Place of Presentation
      Austria Center, Vienna, Austria
    • Year and Date
      20130307-11
  • [Presentation] Intermolecular cross-relaxation rate(CR) and equivalent CR in protein gel2012

    • Author(s)
      S.Era, M. Sogami, S. Matsushima and Y. Kinosada
    • Organizer
      International Conference on Magnetic Resonance in Biological Systems
    • Place of Presentation
      Lyon Convention Center, France
    • Year and Date
      20120819-24
  • [Presentation] Correlation of hepatocellular density and the contrast enhance ratio in hepatocellular imaging.2012

    • Author(s)
      S. Matsushima, Y. Sato, H. Yamaura, M. Kato, D. Inoue, Y. Kinosada, S. Era, K. Takahashi, Y. Inaba
    • Organizer
      2012 European Congress of Radiology.
    • Place of Presentation
      Austria Center,Vienna, Austria
    • Year and Date
      20120301-05
  • [Presentation] Correlation of hepatocellular density and contrast enhance ratio in hepatocellular of the surrounding non-cancerous background liver tissue.2012

    • Author(s)
      S. Matsushima, Y. Sato, H. Yamaura, M. Kato, D Inoue Y. Kinosada, S. Era, T.Kurinobu, Kazuya Takahashi, Y Inaba
    • Organizer
      Radiological Society of North America 98nd Scientific Assembly and Annual Meeting.
    • Place of Presentation
      McCormick Place. Chicago, USA
    • Year and Date
      2012-11-27
  • [Presentation] 細胞外マトリクスの造影効果を考慮したGd-EOB-DTPAの肝細胞相造影率画像2012

    • Author(s)
      松島秀, 佐藤洋造, 山浦秀和, 紀ノ定保臣, 惠良聖一, 高橋和也, 稲葉吉隆
    • Organizer
      第40回日本磁気共鳴医学会大会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2012-09-06
  • [Presentation] Evaluation of future remnant liver function by the contrast enhanced ratio in Hepatocellular imaging2011

    • Author(s)
      S. Matsushima, Y. Sato, H. Yamaura, M. Kato, Y. Kinosada, S. Era, H. Shimizu, Y Inaba
    • Organizer
      Radiological Society of North America 97nd Scientific Assembly and Annual Meeting
    • Place of Presentation
      McCormick Place, Chicago, USA
    • Year and Date
      20111202-1202
  • [Presentation] Preoperative evaluation of future remnant liver function by the contrast enhance ratio in hepatocellular image2011

    • Author(s)
      S. Matsushima, Y. Sato, H. Yamaura, M. Kato, T. Kanamoto, Y. Kinosada, S. Era, H. Koyanagi, Y. Inaba
    • Organizer
      2011 European Congress of Radiology
    • Place of Presentation
      Austria Center, Vienna, Austria
    • Year and Date
      20110303-07
  • [Presentation] Gd-EOB-DTPAを用いた残肝機能の術前評価2011

    • Author(s)
      松島秀, 佐藤洋造, 山浦秀和, 加藤弥菜,井上大作, 紀ノ定保臣, 惠良聖一, 高橋和也、稲葉吉隆
    • Organizer
      第39回日本磁気共鳴医学会大会
    • Place of Presentation
      リーガロイヤルホテル小倉
    • Year and Date
      2011-09-30
  • [Presentation] New imaging tool for the post-radiated parotid gland function2010

    • Author(s)
      H. Shimizu, S. Matsushima, Y. Kinosada, H. Miyamura, T. Kodaira
    • Organizer
      ASTRO'S 52nd Annual Meeting
    • Place of Presentation
      San Diego Convention Center, San Diego
    • Year and Date
      20101031-1104
  • [Presentation] Comparative 1H NMR studied of saturation transfer in copolymer gels and mouse lenses2010

    • Author(s)
      S.Era, M. Sogami, K. Nakamura, S. Matsushima, Y. Kinosada
    • Organizer
      International Conference on Magnetic Resonance in Biological Systems
    • Place of Presentation
      Cairns Queensland, Australia
    • Year and Date
      20100822-27
  • [Presentation] In vitro and in vivo characterization of polymer-water interaction studied by an off-resonance MRI- synthetic copolymer gels and breast carcinoma2010

    • Author(s)
      S. Era, S. Matsushima, M. Sogami and Y. Kinosada
    • Organizer
      World Wide Magnetic Resonance Florence 2010
    • Place of Presentation
      Florence, Itary
    • Year and Date
      20100704-09
  • [Presentation] Gd-EOB-DTPAを用いた肝機能画像2010

    • Author(s)
      松島秀, 佐藤洋造, 山浦秀和, 惠良聖一, 紀ノ定保臣, 稲葉吉隆
    • Organizer
      第38回日本磁気共鳴医学会大会
    • Place of Presentation
      つくば国際会議場
    • Year and Date
      2010-10-02
  • [Presentation] The correlation between liver function and contrast enhanced ratio in the hepatocellular image0

    • Author(s)
      S. Matsushima, Y. Sato, H. Yamaura, Y. Kinosada, S. Era, Y Inaba
    • Organizer
      Radiological Society of North America 96nd Scientific Assembly and Annual Meeting
    • Place of Presentation
      McCormick Place, Chicago, USA
    • Year and Date
      00001129

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Published: 2014-08-29   Modified: 2015-11-04  

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