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2012 Fiscal Year Annual Research Report

塩酸ドネベジルを用いた放射線治療後の高次脳機能低下症に対する新規治療法の開発

Research Project

Project/Area Number 22591384
Research InstitutionKobe University

Principal Investigator

佐々木 良平  神戸大学, 医学部附属病院, 教授 (30346267)

Co-Investigator(Kenkyū-buntansha) 山本 泰司  神戸大学, 医学部附属病院, 講師 (00324921)
Project Period (FY) 2010-04-01 – 2013-03-31
Keywords放射線治療 / 高次脳機能 / 塩酸ドネベジル / 有害反応
Research Abstract

放射線照射後に高次脳機能障害を認め、その原因として治療前からの認知症を除外できた症例に対して臨床試験を実施した。臨床試験の適確基準、除外基準には若干の微修正が必要であった。本研究機関では4例の症例が登録され、その内訳は原発性高悪性度神経膠腫1例、原発性低悪性度神経膠腫1例、中枢神経悪性リンパ腫1例、転移性脳腫瘍1例であった。年齢の内訳は30歳、67歳、72歳、72歳で、男性3例、女性1例であった。放射線照射の方法は全脳照射2例、拡大局所照射2例であり、前頭葉や側頭葉への照射線量は30Gy~60Gyであった。3例に放射線治療前の腫瘍摘出術が施行されていた。高次脳機能テストは全例治療前に実施し、その後は塩酸ドネベジルの服用3ヶ月、6ヶ月、12ヶ月に実施した。高次脳機能テストで主治医とは異なる観察者による客観的な評価の結果では、塩酸ドネベジルの放射線治療後の高次脳機能に対する効果は、症例ごとに程度の差はあるものの全例で認められ、本治療方法の有効性が示唆された。塩酸ドネベジルの服用は全例で可能であり、1例の他原因で死亡した症例を除く3例で当初の計画通り服用でき、Grade 2以上の有害反応を認めなかった。本治療は放射線治療における高次脳機能低下に対する有効な治療手段の一つになると考えられ、今後は症例の適確基準を再検討し、より多くの症例でその効果を検討していきたいと考えている。また、塩酸ドネベジルの投与量に関しても再検討する事によって更に良好な治療成績が得られる可能性もあり、追加検討中である。

Current Status of Research Progress
Reason

24年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

24年度が最終年度であるため、記入しない。

  • Research Products

    (35 results)

All 2013 2012

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (23 results) Book (3 results)

  • [Journal Article] Multi-institutional analysis of solitary extramedullary plasmacytoma of the head and neck treated with curative radiotherapy.2012

    • Author(s)
      Sasaki R
    • Journal Title

      Int J Radiat Oncol Biol Phys.

      Volume: 82(2) Pages: 626-34

    • DOI

      10.1016/j.ijrobp.2010.11.037

    • Peer Reviewed
  • [Journal Article] Long-term outcome and patterns of failure in primary ocular adnexal mucosa-associated lymphoid tissue lymphoma treated with radiotherapy.2012

    • Author(s)
      Hashimoto N
    • Journal Title

      10.1016/j.ijrobp.2011.04.052

      Volume: 82(4) Pages: 1509-14

    • DOI

      Int J Radiat Oncol Biol Phys.

    • Peer Reviewed
  • [Journal Article] Patterns of failure after multimodal treatments for high-grade glioma: effectiveness of MIB-1 labeling index.2012

    • Author(s)
      Uehara K
    • Journal Title

      Radiat Oncol

      Volume: 26 Pages: 104

    • DOI

      10.1186/1748-717X-7-104.

    • Peer Reviewed
  • [Journal Article] Efficacy of intraoperative radiotherapy targeted to the abdominal lymph node area in patients with esophageal carcinoma.2012

    • Author(s)
      Tamaki Y
    • Journal Title

      J Radiat Res.

      Volume: 53(6) Pages: 882-91

    • DOI

      10.1093/jrr/rrs045.

    • Peer Reviewed
  • [Journal Article] Radiotherapy for stage I or II hypopharyngeal carcinoma.2012

    • Author(s)
      Nishimura H
    • Journal Title

      J Radiat Res.

      Volume: 53(6) Pages: 892-9

    • DOI

      10.1093/jrr/rrs044

    • Peer Reviewed
  • [Journal Article] Monogalactosyl diacylglycerol, a replicative DNA polymerase inhibitor, from spinach enhances the anti-cell proliferation effect of gemcitabine in human pancreatic cancer cells.2012

    • Author(s)
      Akasaka H
    • Journal Title

      Biochim Biophys Acta.

      Volume: 1830(3) Pages: 2517-2525

    • DOI

      10.1016/j.bbagen.2012.11.004

    • Peer Reviewed
  • [Journal Article] A case of squamous cell carcinoma with pagetoid features in the oral mucosa.2012

    • Author(s)
      SHIBUYA Y
    • Journal Title

      Hospital Dentistry & Oral-Maxillofacial Surgery

      Volume: 24(2) Pages: 63-68

    • Peer Reviewed
  • [Journal Article] Long-term outcome of hypofractionated radiotherapy to the whole breast of Japanese women after breast-conserving surgery2012

    • Author(s)
      Ishihara T
    • Journal Title

      Breast Cancer

      Volume: F22 Pages: 00

    • Peer Reviewed
  • [Journal Article] A phase I/II study of gemcitabine-concurrent proton radiotherapy for locally advanced pancreatic cancer without distant metastasis.2012

    • Author(s)
      Terashima K
    • Journal Title

      Radiother Oncol.

      Volume: 103(1) Pages: 25-31

    • DOI

      10.1016/j.radonc.2011.12.029.

    • Peer Reviewed
  • [Presentation] Radiotherapy for Japanese elderly patients with cervical cancer2013

    • Author(s)
      Yoshida K
    • Organizer
      European Congress of Radiology(ECR)
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      20130317-20130321
  • [Presentation] Ten Year Experience with Combined Modality Therapy Including Radiotherapy for Squamous Cell Carcinomas of Oropharynx2013

    • Author(s)
      Miyawaki D
    • Organizer
      European Congress of Radiology(ECR)
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      20130317-20130321
  • [Presentation] Combination Efficacy of MGMT Promoter Methylation Status and MIB-1 Labeling Index for Pattern of Recurrence in Glioblastoma2012

    • Author(s)
      Uehara K
    • Organizer
      98th Scientific Assembly and Annual Meeting of The Radiological Society of North America
    • Place of Presentation
      Chicago, USA
    • Year and Date
      20121125-20121130
  • [Presentation] Efficacy of Surgically Implanted Flexible Spacer in Particle Therapy: A novel strategy Making Temporal Space between Tumor and Adjacent Organs2012

    • Author(s)
      Akasaka H
    • Organizer
      54th ASTRO Annual Meeting
    • Place of Presentation
      Boston, USA
    • Year and Date
      20121028-20121031
  • [Presentation] Stereotactic Body Radiation Therapy in 95 Patients With Lung Tumors Composed of Ground-glass Opacity (GGO): Results of a Retrospective Multicenter Study2012

    • Author(s)
      Onishi H
    • Organizer
      54th ASTRO Annual Meeting
    • Place of Presentation
      Boston, USA
    • Year and Date
      20121028-20121031
  • [Presentation] Patterns of Local Recurrence and Metachronous Malignancy Following Radiation Therapy for Stage I or II Hypopharyngeal Carcinoma: Role of Close Observation and Multidisciplinary Approach2012

    • Author(s)
      Nishimura H
    • Organizer
      54th ASTRO Annual Meeting
    • Place of Presentation
      Boston, USA
    • Year and Date
      20121028-20121031
  • [Presentation] Novel Radiosensitization Through Reactive Oxygen Species Generation Using Titanium Peroxide Nanoparticle Compounds Against Pancreas Cancer2012

    • Author(s)
      Nakayama M
    • Organizer
      54th ASTRO Annual Meeting
    • Place of Presentation
      Boston, USA
    • Year and Date
      20121028-20121031
  • [Presentation] Involved-Field Radiation Therapy Using Protons or Carbon Ions for N1-2M0 Non-small Cell Lung Cancer: A Retrospective Study2012

    • Author(s)
      Fujii O
    • Organizer
      54th ASTRO Annual Meeting
    • Place of Presentation
      Boston, USA
    • Year and Date
      20121028-20121031
  • [Presentation] Hypofractionated Stereotactic Radiation Therapy for Brain Metastases: Exploration of Adhibition and Key Factors Involved in Local Control Rate2012

    • Author(s)
      Ishihara T
    • Organizer
      54th ASTRO Annual Meeting
    • Place of Presentation
      Boston, USA
    • Year and Date
      20121028-20121031
  • [Presentation] Radiation therapy for brainstem gliomas in children and adults2012

    • Author(s)
      Yoshida K
    • Organizer
      The 14th Asian Oceanian Congress of Radiology
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      20120831-20120902
  • [Presentation] Surgically Implanted Flexible Spacer in Particle Therapy: Making Temporal Space between Tumor and Adjacent Organs!2012

    • Author(s)
      Sasaki R
    • Organizer
      The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
    • Place of Presentation
      Hiroshima, Japan
    • Year and Date
      20120719-20120721
  • [Presentation] Radiotherapy for Squamous Cell Carcinomas of Oropharynx2012

    • Author(s)
      Miyawaki D
    • Organizer
      The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
    • Place of Presentation
      Hiroshima, Japan
    • Year and Date
      20120719-20120721
  • [Presentation] Postoperative radiotherapy for the malignant tumors of the parotid gland2012

    • Author(s)
      Muraoka O
    • Organizer
      The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
    • Place of Presentation
      Hiroshima, Japan
    • Year and Date
      20120719-20120721
  • [Presentation] Therapeutic Strategies aimed at Laryngeal Preservation of T1-T3N0 Glottic Laryngeal cancer2012

    • Author(s)
      Harada A
    • Organizer
      The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
    • Place of Presentation
      Hiroshima, Japan
    • Year and Date
      20120719-20120721
  • [Presentation] Clinical results of Particle beam radiation therapy for Lung metastases2012

    • Author(s)
      Shazurina Nor
    • Organizer
      The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
    • Place of Presentation
      Hiroshima, Japan
    • Year and Date
      20120719-20120721
  • [Presentation] Evaluation of Newly Developed Nanoparticles on Radiosensitization Effect in Pancreas Cancer Tumor Models2012

    • Author(s)
      Nakayama M
    • Organizer
      The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
    • Place of Presentation
      Hiroshima, Japan
    • Year and Date
      20120719-20120721
  • [Presentation] A Novel Radiosensitizor, Monogalactosyldiacyglycerol (MDGD) from Spinach, Enhanced the Cytotoxicity of Radiotherapy to Pancreatic Cancer2012

    • Author(s)
      Akasaka H
    • Organizer
      The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
    • Place of Presentation
      Hiroshima, Japan
    • Year and Date
      20120719-20120721
  • [Presentation] Normal tissue tolerance microbeam X-ray irradiation2012

    • Author(s)
      Mukumoto N
    • Organizer
      The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
    • Place of Presentation
      Hiroshima, Japan
    • Year and Date
      20120719-20120721
  • [Presentation] Chemoradiotherapy in Patients with Locally Advanced Unresectable Esophageal Squamous Cell Carcinoma2012

    • Author(s)
      Nishimura H
    • Organizer
      The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
    • Place of Presentation
      Hiroshima, Japan
    • Year and Date
      20120719-20120721
  • [Presentation] Radiation therapy for brainstem gliomas in children and adults2012

    • Author(s)
      Yoshida K
    • Organizer
      The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
    • Place of Presentation
      Hiroshima, Japan
    • Year and Date
      20120719-20120721
  • [Presentation] Impact of MGDG Promoter Methylation Status and MIB-1 Labeling Index on Recurrence Pattern after Multimodal Treatment in Glioblastoma2012

    • Author(s)
      Uehara K
    • Organizer
      The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
    • Place of Presentation
      Hiroshima, Japan
    • Year and Date
      20120719-20120721
  • [Presentation] Stereotactic Body Radiation Therapy for Lung Cancer in Octogenarians2012

    • Author(s)
      Ishihara T
    • Organizer
      The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
    • Place of Presentation
      Hiroshima, Japan
    • Year and Date
      20120719-20120721
  • [Presentation] Hypofractionated stereotactic radiotherapy for brain metastases:Exploration of adhibition and key factors involved in local control rate2012

    • Author(s)
      Ishihara T
    • Organizer
      The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
    • Place of Presentation
      Boston, USA
    • Year and Date
      20120719-20120721
  • [Book] 最新放射線医学(放射線医学総論) 第8巻2章 放射線治療計画2012

    • Author(s)
      西村英輝
    • Total Pages
      6-9
    • Publisher
      金芳堂
  • [Book] 最新放射線医学(放射線医学総論) 第8巻7章 放射線治療における医療事故防止2012

    • Author(s)
      吉田賢史
    • Total Pages
      39-43
    • Publisher
      金芳堂
  • [Book] 最新放射線医学(放射線医学総論) 第8巻19章 皮膚・軟部・骨疾患の放射線治療2012

    • Author(s)
      佐々木良平
    • Total Pages
      135-138
    • Publisher
      金芳堂

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Published: 2014-07-24  

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