2012 Fiscal Year Final Research Report
Efficacy of donepezil HCl to higher brain dysfunction after radiation therapy
| Project/Area Number |
22591384
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kobe University |
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Principal Investigator |
SASAKI Ryohei 神戸大学, 医学部附属病院, 特命教授 (30346267)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Yasuji 神戸大学, 医学部付属病院, 講師 (00324921)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 塩酸ドネべジル / 放射線治療 / 高次脳機能 |
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| Research Abstract |
We peformed clinical trials against higher brain dysfunction after radiation therapy. Among this period, 4 cases were enrolled in this study. There were a patient with glioblastoma, a patient with low grade glioma, a patients with CNS lymphoma, and a patient with metastatic brain tumor. There were 3 male and 1 female patients. They were 30, 67, 72 years old, respectively. Radiation fields were set as whole brain irradiation in 2 patients, and localized fields in other 2 patients. Radiation doses were ranging from 30-60 Gy. Efficacy of donepezil HCl were observed in all cases. There were no case who experienced more than Grade 2 morbidity. In conclusion, donepezil HCl seemed to be effective and safe treatment option against higher brain dysfunction after radiation therapy
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Research Products
(42 results)
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[Journal Article] Long-Term Outcome of Proton Therapy and Carbon-Ion Therapy for Large (T2a-T2bN0M0) Non-Small-Cell Lung Cancer2013
Author(s)
Iwata H, Demizu Y, Fujii O, Terashima K, Mima M, Niwa Y, Hashimoto N, Akagi T, Sasaki R,Hishikawa Y, Abe M, Shibamoto Y, Murakami M, Fuwa N
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Journal Title
DOI
Peer Reviewed
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[Journal Article] Patterns of failure after multimodal treatments for high-grade glioma: effectiveness of MIB-1 labeling index2012
Author(s)
Uehara K, Sasayama T, Miyawaki D, Nishimura H, Yoshida K, Okamoto Y, Mukumoto N, Akasaka H, Nishihara M, Fujii O, Soejima T, Sugimura K, Kohmura E, Sasaki R
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Journal Title
Radiat Oncol
Volume: 7
Pages: 104
Peer Reviewed
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[Journal Article] A phase I/II study of gemcitabine-concurrent proton radiotherapy for locally advanced pancreatic cancer without distant metastasis2012
Author(s)
Terashima K, Demizu Y, Hashimoto N, Jin D, Mima M, Fujii O, Niwa Y, Takatori K, Kitajima N, Sirakawa S, Yonson K, Hishikawa Y, Abe M, Sasaki R, Sugimura K, Murakami M
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Journal Title
Radiother Oncol
Volume: 103(1)
Pages: 25-31
Peer Reviewed
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[Journal Article] Sugimura K.Long-term Outcome and Patterns of Failure in Primary Ocular Adnexal MALT Lymphoma Treated with Radiotherapy2012
Author(s)
Hashimoto N, Sasaki R, Nishimura H, Yoshida K, Miyawaki D, Nakayama M, Uehara K, Okamoto Y, Ejima Y, Azumi A, Matsui T
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Journal Title
Int J Radiat Oncol Biol Phys
Volume: 82(4)
Pages: 1509-14
Peer Reviewed
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[Journal Article] Multi-institutional Analysis of Solitary Extramedullary Plasmacytoma of the Head and Neck Treated with Curative Radiotherapy2012
Author(s)
Sasaki R, Yasuda K, Abe E, Uchida N, Kawashima M, Uno T, Fujiwara M, Shioyama Y, Kagami Y, Shibamoto Y, Nakata K, Takada Y, Kawabe T, Uehara K, Nibu K, Yamada S.
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Journal Title
Int J Radiat Oncol Biol Phys
Volume: 82(2)
Pages: 626-34
Peer Reviewed
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[Journal Article] The effectiveness of particle radiotherapy for hepatocellular carcinoma associated with inferior vena cava tumor thrombus2011
Author(s)
Komatsu S, Fukumoto T, Demizu Y, Miyawaki D, Terashima K, Niwa Y, Mima M, Fujii O, Sasaki R, Yamada I, Hori Y, Hishikawa Y, Abe M, Ku Y, Murakami M.
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Journal Title
J Gastroenterol
Volume: 46(7)
Pages: 913-20
Peer Reviewed
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[Journal Article] Suzuki, Miki Saitoh, Naoki Otsuki, Yoshitake Hayashi, Toshinori Soejima, Kenichi Nibu, and Kazuro Sugimura2010
Author(s)
Kenji Yoshida, Ryohei Sasaki,Hideki Nishimura, Yoshiaki Okamoto, Yoko
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Journal Title
Nuclear Factor-kappa B Expression as a Novel Marker of Radioresistance: In Early Stage Laryngeal Cancer, Head Neck.
Volume: 32(5)
Pages: 646-55
DOI
Peer Reviewed
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[Journal Article] Vitamin K2-derived Compounds Induce Growth Inhibition in Radioresistant Cancer Cells2010
Author(s)
Amalia H, Sasaki R,Suzuki Y, Demizu Y, Bito T, Nishimura H, Okamoto Y, Yoshida K, Miyawaki D, Kawabe T, Mizushina Y, and Kazuro S
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Journal Title
Kobe J Med Sci
Volume: 56(2)
Pages: 38-49
Peer Reviewed
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[Presentation] Treatment Outcomes of Particle Radiotherapy Using Protons or Carbon Ions as a Single-Modality Therapy for Adenoid Cystic Carcinoma of the Head and Neck2011
Author(s)
Y. Demizu, K. Terashima, M. Mima, O. Fujii, Y. Niwa, K. Morimoto, R. Sasaki, Y. Hishikawa, M. Abe, M. Murakami.
Organizer
53rd ASTRO
Place of Presentation
Miami, Florida, USA
Year and Date
20111002-06
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[Presentation] Dosimetric Analysis of Patterns of Failure for High-grade Glioma with Multimodality Treatment: Relationship to MIB-1 Labeling Index2011
Author(s)
K. Uehara, R. Sasaki, D. Miyawaki, H. Nishimura, K. Yoshida, M. Nakayama, T. Soejima, O. Fujii, T. Sasayama, K. Sugimura
Organizer
53rd ASTRO
Place of Presentation
Miami, Florida, USA
Year and Date
20111002-06
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[Presentation] Combined Modality Therapy Including Radiotherapy for Squamous Cell Carcinomas of Maxillary Sinus: A Retrospective Study2011
Author(s)
D. Miyawaki, H. Nishimura, K. Yoshida, O. Muraoka, M. Nakayama, K. Uehara, S. Hasegawa, K. Nibu, K. Sugimura, R. Sasaki.
Organizer
53rd ASTRO
Place of Presentation
Miami, Florida, USA
Year and Date
20111002-06
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[Presentation] Long-term Outcome and Patterns of Failure in Primary Ocular Adnexal MALT Lymphoma Treated with Radiotherapy2011
Author(s)
N. Hashimoto, R. Sasaki, H. Nishimura, K. Yoshida, D. Miyawaki, Y. Okamoto, Y. Ejima, A. Azumi, T. Matsui, K. Sugimura
Organizer
53rd ASTRO
Place of Presentation
Miami, Florida, USA
Year and Date
20111002-06
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[Presentation] Microplanar Beams Radiation: Is Brain Really A Serial Organ2011
Author(s)
N. Mukumoto, R. Sasaki, H. Akasaka, M. Nakayama, D. Miyawaki, H. Nishimura, K. Umetani, T. Kondoh, K. Shinohara, K. Sugimura
Organizer
53rd ASTRO
Place of Presentation
Miami, Florida, USA
Year and Date
20111002-06
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[Presentation] Combined Modality Therapy Including Radiotherapy for Squamous Cell Carcinomas of Maxillary Sinus - a Retrospective Study2011
Author(s)
D. Miyawaki, H. Nishimura, K. Yoshida, O. Muraoka, M. Nakayama, K. Uehara, K. Sugimura, S. Hasegawa, K. Nibu, R. Sasaki
Organizer
16th ECCO.
Place of Presentation
Stockholm , Sweden
Year and Date
20110924-28
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[Presentation] Particle-BeamRadiation Therapy for Skull Base Chordomas:A Retrospective Study.2010
Author(s)
D.Miyawaki, Y.Demizu, K.Terashima, M.Mima, O.Fujii, Y.Niwa, K.Yoshida, H.Nishimura, R. Sasaki, M.Murakami
Organizer
52nd ASTRO.
Place of Presentation
SanDiego, CA, USA
Year and Date
20101031-1104
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[Presentation] Particle-BeamRadiation Therapy for Skull Base Chordomas:A Retrospective Study2010
Author(s)
D.Miyawaki, Y.Demizu, K.Terashima, M.Mima, O.Fujii, Y.Niwa, K.Yoshida, H.Nishimura, R.Sasaki, M.Murakami
Organizer
52nd ASTRO.
Place of Presentation
SanDiego, CA, USA
Year and Date
20101031-1104
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[Presentation] Particle Radiotherapy using Protons or Carbon Ions for Adenoid Cystic Carcinoma of the Head and Neck2010
Author(s)
Y.Demizu, K.Terashima, M.Mima, O.Fujii, Y.Niwa, K.Morimoto, Y.Hishikawa, M.Abe, M.Murakami.
Organizer
52nd ASTRO
Place of Presentation
SanDiego, CA, USA
Year and Date
20101031-1104
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