2012 Fiscal Year Final Research Report
Assessment of donor specific anti-HLA antibody production after livertransplant recipient for establishment of tailored immunosuppression
| Project/Area Number |
22591409
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
INOMATA Yukihiro 熊本大学, 大学院・生命科学研究部, 教授 (50193628)
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| Co-Investigator(Kenkyū-buntansha) |
ASONUMA Katsuhiro 熊本大学, 医学部附属病院移植医療学寄付講座, 教授 (40202626)
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| Research Collaborator |
HAYASHIDA Sinntarou 熊本大学, 医学部附属病院, 医員
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| Project Period (FY) |
2010 – 2012
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| Keywords | 肝移植 / 抗ドナー抗体 / HLA / LAB Screen 法 |
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| Research Abstract |
Anti-HLA antibody (a-HLA Ab) and donor specific antibody (DSA) in recipients were measuredbefore and after the living donor liver transplantation (LDLT), using LAB Screen singleantigen examination. Both titers of a-HLA Ab and DSA did not show significant correlationwith the post-transplant survival. Prevalence of post-transplant DSA was 0% in classI and 15% in class II. This study showed the dynamics of anti-donor antibody in LDLT,and presented the basic data for the research of antibody-mediated immunoreaction in livertransplantation.
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