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2012 Fiscal Year Final Research Report

Role of prevascularization of islets in the induction of tolerance of allogeneic islets in miniature swine

Research Project

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Project/Area Number 22591417
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionNippon Medical School

Principal Investigator

HIRAKATA Atsushi  日本医科大学, 医学部, 助教 (40468765)

Co-Investigator(Kenkyū-buntansha) YAMADA Kazuhiko  鹿児島大学, 医用ミニブタ・先端医療開発研究センター, 教授 (40241103)
SASHARA Hisashi  鹿児島大学, 医用ミニブタ・先端医療開発研究センター, 特任准教授 (90452333)
Co-Investigator(Renkei-kenkyūsha) SHIMIZU Akira  日本医科大学, 医学部, 准教授 (00256942)
Project Period (FY) 2010 – 2012
Keywords移植外科学 / 膵島移植 / 移植後免疫寛容 / ミニブタ / 腎移植 / 膵島・腎移植 / 血管再構築
Research Abstract

We have previously reported successful induction of tolerance of allogeneic islets by transplantation of islets as a form of composite islet-kidney in preclinical MHC inbred miniature swine while all islets were rejected when islets were injected as islet cell transplantation. This study aimed to determine whether vascularized islets have the ability to induce tolerance without renal graft.

  • Research Products

    (5 results)

All 2013 2011 2010

All Journal Article (3 results) Presentation (2 results)

  • [Journal Article] The induction of tolerance of renal allografts by adoptive transfer in miniature Swine.2013

    • Author(s)
      Okumi M, Hirakata A, Yamada K
    • Journal Title

      Am J Transplant.

      Volume: 13(5) Pages: 1193-202

  • [Journal Article] Composite islet-kidneys from single baboon donors cure diabetes across fully allogenic barriers.2011

    • Author(s)
      Yamada K and Hirakata A
    • Journal Title

      Am J Transplant.

      Volume: 11(12) Pages: 2603-12.

  • [Journal Article] Reversal of age-related thymic involution by an LHRH agonist in miniature swine.2010

    • Author(s)
      Hirakata A and Yamada K
    • Journal Title

      Transpl Immunol.

      Volume: 24(1) Pages: 76-81

  • [Presentation] SOTA 6- Barriers to vascularized xenotransplantation solid organ Xenotransplantation: Overcome cellular immune responses.2011

    • Author(s)
      Yamada K.
    • Organizer
      CTS (Cell Transplant Society) -IXA (International Xenotransplantation Association) 2011 Joint Congress.
    • Place of Presentation
      Miami beach, FL, US.
    • Year and Date
      20111023-26
  • [Presentation] ワークショップ3.膵・膵島移植の現状と今後の課題」血管再構築と免疫寛容誘導戦略に基づく重症糖尿病性腎症根治療法の確立2010

    • Author(s)
      山田和彦
    • Organizer
      第46回日本移植学会総会
    • Place of Presentation
      京都市
    • Year and Date
      20101020-22

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Published: 2014-08-29  

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