2012 Fiscal Year Final Research Report

The clarify of the mechanism of induction of immunological tolerance using mouse liver transplantation model and development of novel immunosuppression.

Research Project

Project/Area Number	22591418
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	General surgery
Research Institution	National Research Institute for Child Health and Development (2011-2012) Fujita Health University (2010)
Principal Investigator	MORITA Miwa 独立行政法人国立成育医療研究センター, RI管理室, 共同研究員 (90329699)
Co-Investigator(Kenkyū-buntansha)	RII Kou (独)国立成育医療センター, RI管理室, 室長 (60321890) SUGIOKA Atsushi 藤田保健衛生大学, 医学部, 教授 (20171150)
Project Period (FY)	2010 – 2012
Keywords	移植免疫 / 免疫寛容 / マウス同所性肝移植モデル / マイクロRNA / 骨髄由来免疫抑制細胞
Research Abstract	For the development of novel imunosuppression in organ transplantation, we have analyzed the mechanism of graft acceptance using orthotopic mouse liver transplantation, which can induce immunological tolerance without immunosuppressive drugs. It shows that one of the co-stimulatory molecule, PD-1/PD-L1 pathway is essential for graft acceptance. And it has analyzed that microRNA which associated with rejection or acceptance of allografts. And it suggested that myeloid-derived suppressor cells has an important role for inhibition for graft rejection.