2012 Fiscal Year Final Research Report
The study that nitroglycerin treatment may increase response to chemotherapy via inhibitions of hypoxia-inducible factor-1 pathway in patients with breast cancer.
| Project/Area Number |
22591420
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
AMARI Masakazu 東北大学, 大学院・医学系研究科, 准教授 (50400312)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIDA Takanori 東北大学, 大学院・医学系研究科, 准教授 (00292318)
KAWAI Masaaki 東北大学, 大学院・医学系研究科, 助教 (80513530)
OHUCHI Noriaki 東北大学, 大学院・医学系研究科, 教授 (90203710)
YASUDA Hiroyasu 東北大学, 大学院・医学系研究科, 非常勤講師 (90396482)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 乳腺外科学 / 一酸化窒素供与剤 / HIF-1α / HK II |
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| Research Abstract |
This study suggest that HK II is induced by HIF-1α and plays important roles in the proliferation and/or progression of breast cancer by increased glycolytic activity. HK II status is considered a potent prognostic factor in human breast cancer patients.
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