2012 Fiscal Year Final Research Report
Development of hyperthermia using magnetic cationic liposome for refractory breast cancer and thyroid cancer
| Project/Area Number |
22591429
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
IMAI Tsuneo 名古屋大学, 医学部附属病院, 講師 (80252245)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAO Akimasa 名古屋大学, 大学院・医学系研究科, 教授 (70167542)
KOBAYASHI Takeshi 中部大学, 応用生物学部, 教授 (10043324)
KIKUMORI Toyone 名古屋大学, 医学部附属病院, 講師 (90402635)
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| Research Collaborator |
AKIYMA Masashi 名古屋大学, 大学院・医学系研究科, 教授 (60222551)
YOKOTA Kenji 名古屋大学, 大学院・医学系研究科, 助教 (20456651)
NISHIDA Yoshihiro 名古屋大学, 大学院・医学系研究科, 准教授 (50332698)
FUJIMOTO Yasushi 名古屋大学, 大学院・医学系研究科, 講師 (40344337)
YAMAMOTO Noriyuki 名古屋大学, 大学院・医学系研究科, 助教 (60378156)
FURUE Hiroki 名古屋大学, 医学部附属病院, 助教 (40567012)
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| Project Period (FY) |
2010 – 2012
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| Keywords | マグネトリポソーム / 温熱療法 / 陽性荷電 / 交番磁場照射 / 乳癌 / 甲状腺癌 / 第I相臨床試験 |
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| Research Abstract |
A phase I study of hyperthermia using magnetic cationic liposome (MCL) and alternate magnetic field was conducted. Patients with refractory breast cancer, thyroid cancer, soft tissue sarcoma, and tongue cancer were enrolled. MCL (5mg/body) was locally injected to the recurrence site and alternate magnetic field was irradiated for 30 minutes to keep the temperature of the skin at 43 degree Celsius in the first 3 patients. MCL (50mg/body) was given and hyperthermia was conducted in the same manner in the next 3 patients. No adverse event was observed in all patients. The pathological examination 2 weeks after hyperthermia showed various local effects such as tumor necrosis, but there was no systemic benefit.
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Research Products
(16 results)
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[Journal Article] T-cell receptor repertoires of tumor-infiltrating lymphocytes after hyperthermia using functionalized magnetite nanoparticles2012
Author(s)
Ito A, Yamaguchi M, Okamoto N, Sanematsu Y, Kawabe Y, Wakamatsu K, Ito S, Honda H, Kobayashi T, Nakayama E, Tamura Y, Okura M, Yamashita T, Jimbow K, Kamihira M.
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Journal Title
Peer Reviewed
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[Journal Article] Impact of novel oncolytic virus HF10 on cellular components of the tumor microenviroment in patients with recurrent breast cancer2012
Author(s)
Sahin TT, Kasuya H, Nomura N, Shikano T, Yamamura K, Gewen T, Kanzaki A, Fujii T, Sugae T, Imai T, Nomoto S, Takeda S, Sugimoto H, Kikumori T, Kodera Y, Nishiyama Y, Nakao A
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Journal Title
Cancer Gene Ther
Volume: 19
Pages: 229-237
Peer Reviewed
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[Journal Article] Phase I/II study of intraoperative radiotherapy for early breast cancer in Japan2012
Author(s)
Sawaki M, Sato S, Noda S, Idota A, Uchida H, Tsunoda N, Kikumori T, Aoyama Y, Ishihara S, Itoh Y, Imai T
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Journal Title
DOI
Peer Reviewed
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[Journal Article] Prospective evaluation of corrected QT intervals and arrhythmias after exposure to epirubicin, cyclophosphamide, and 5-fluorouracil in women with breast cancer2012
Author(s)
Kitagawa K, Kawada K, Morita S, Inada M, Mitsuma A, Sawaki M, Iino S, Inden Y, Murohara T, Imai T, Ando Y
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Journal Title
Ann Oncol
Volume: 23
Pages: 743-747
Peer Reviewed
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[Journal Article] Optimization of hyperthermia and dendritic cell immunotherapy for squamous cell carcinoma2011
Author(s)
Matsumoto K, Yamamoto N, Hagiwara S, Saito M, Furue H, Shigetomi T, Narita Y, Mitsudo K, Tohnai I, Kobayashi T, Ueda M.
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Journal Title
Oncol Rep
Volume: 25(6)
Pages: 1525-32
Peer Reviewed
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