2012 Fiscal Year Final Research Report
Study of growth factors in intestinal failure
| Project/Area Number |
22591432
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Osaka University |
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Principal Investigator |
WASA Masafumi 大阪大学, 医学系研究科, 准教授 (10240467)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUZAWA Masahiro 大阪大学, 医学系研究科, 准教授 (60165272)
SOH Hideki 大阪大学, 医学系研究科, 助教 (00457011)
UEHARA Shuichiro 大阪大学, 医学系研究科, 助教 (00448060)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 腸管不全 / 再生促進因子 / グルタミン |
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| Research Abstract |
The purpose of the present study was to examine the effect of glutamine on mucosal damage induced by cyclophosphamide in a rat and elucidate the mechanism for its protective effects. Glutamine prevents intestinal mucosal injury induced by cyclophosphamide by the mechanism of increased glutathione, decreased apoptosis and increased proliferation of intestinal epithelial cells.
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