2012 Fiscal Year Final Research Report
Effect of traditional Japanese medicine (Kampo) to cisplatin induced abnormal digestive contractions -Rikkunshito and ghrelin-
| Project/Area Number |
22591449
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Gunma University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHNO Tetsuro 群馬大学, 大学院・医学系研究科, 助教 (60451712)
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| Project Period (FY) |
2010 – 2012
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| Keywords | シスプラチン / 消化管運動 / 嘔気 / 嘔吐 / 六君子湯 / 漢方 |
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| Research Abstract |
Cisplatin given intravenously produced abnormal motor activity that lasted up to 5 hours. 5HT3 receptor antagonist inhibited cisplatin induced an abnormal motor activity, but Rikkunshito did not inhibit it. The 5-HT concentration in plasma reached a peak at 4 hours after cisplatin administration. In a fasting state, intragastric administration of rikkunshito induced phasic contractions in the duodenum and jejunum in normal dogs. Rikkunshito-induced contractions were inhibited by atropine and hexamethonium. Gastric emptying was accelerated by intragastric administration of rikkunshito in a dose-dependent manner. The plasma acylated ghrelin level 150 min after intragastric administration of4.0 g of rikkunshito was significantly higher than the control value. These findings indicate that the contractile effect of rikkunshito is mediated by cholinergic neurons and that 5-HT3 receptors have apartial role in this action.
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[Journal Article] Rikkunshito, a Traditional Japanese Medicine, Suppresses Cisplatin-Induced Anorexia in Humans2011
Author(s)
Ohno T, Yanai M, Ando H, Toyomasu Y, Ogawa A, Morita H, Ogata K, Mochiki E, Asao T, Kuwano H
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Journal Title
ClinExp Gastroenterol
Volume: 4
Pages: 291-296
Peer Reviewed
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