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2014 Fiscal Year Final Research Report

Breakthrough of mechanism in micrometastasis using micrometastatic model of esophageal cancer

Research Project

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Project/Area Number 22591450
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionGunma University

Principal Investigator

MIYAZAKI Tatsuya  群馬大学, 医学部附属病院, 助教 (70372349)

Co-Investigator(Kenkyū-buntansha) YOKOBORI Takehiko  群馬大学, 医学系研究科, 助教 (60420098)
SAKAI Makoto  群馬大学, 医学部附属病院, 助教 (70420099)
SOHDA Makoto  群馬大学, 医学部附属病院, 助教 (70507326)
KUWANO Hiroyuki  群馬大学, 医学系研究科, 教授 (90186560)
Project Period (FY) 2010-04-01 – 2015-03-31
Keywords微小転移
Outline of Final Research Achievements

We have established mice model to evaluate peritoneal micro metastatic nest, because we could not establish orthotopic transplantation model. We used colon-26-luc cell line and 7-week-old female Balb-c mice. We could visualize micro peritoneal cancer nest as a light of luciferase. We also measured the weight of peritoneal tissue to quantify tumor volume, that related luminescence intensity. We establish the method to evaluate disease progression without sacrifice of mice.

Free Research Field

外科学

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Published: 2016-06-03  

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