2012 Fiscal Year Final Research Report
Development of the systems in early detection and prediction of chemo and/or radiation sensitivity for digestive tract cancers using a novel cancer-associated gene, SMYD2
| Project/Area Number |
22591465
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OTSUJI Eigo 京都府立医科大学, 医学研究科, 教授 (20244600)
KOMATSU Shuhei 京都府立医科大学, 医学研究科, 助教 (40578978)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 癌遺伝子 / SMYD2 |
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| Research Abstract |
We investigated the significance of cancer-related gene, SMYD2 overexpression in the chemo and/or radiation sensitivity for digestive cancers. However, until now, we have notyet obtained the date to indicate the association. Whereas, we demonstrated that clinical impact of cancer detection and prognostic prediction using plasma DNA and its plasma SMYD2/RUNX3 ratio in esophageal squamous cell carcinoma. Furthermore, we proved that overexpression of SMYD2 is related to tumor progression in hepatocelluler carcinomacell lines. Also, higher expression of SMYD2 protein is associated with venous invasion and poorer prognosis in patients with carcinoma of the papilla of Vater . We will continue to examine the detail molecular mechanism of SMYD2 and report them in near future.
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