2012 Fiscal Year Final Research Report
Clinical significance of ubiquitin-like protein in esophageal squamous cell carcinoma
| Project/Area Number |
22591470
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIDA Atsuo 東京慈恵会医科大学, 医学部, 助教 (00338906)
OMURA Nobuo 東京慈恵会医科大学, 医学部, 准教授 (70271301)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKADA Koji 東京慈恵会医科大学, 医学部, 准教授 (30179452)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ユビキチン / SUMO-1 / 食道癌 |
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| Research Abstract |
SUMO-1(small ubiquitin-related modifier-1) is a novel ubiquitin -like protein that is conjugated like ubiquitin by a set of enzymes to cellular regulatory proteins including oncogenes and tumor suppressor genes. In this study, we aimed to investigate the significance of SUMO-1 expressions in esophageal cancer as a prognostic factor. In an esophagus cancer, revelation of SUMO-1 was accepted with a core or cytoplasm and SUMO-1 binding protein of varieties was accepted. The high revelation group had intentionally much lymph node metastasis and vessel invasion. Moreover, the life prognosis also accepted the tendency for a high revelation group to be bad.
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[Journal Article] Complete response of esophageal small cell carcinoma amrubicin treatment2012
Author(s)
Nagasaki E, Yuda M, Tanishima Y, Arakawa Y, Kobayashi K, Sakuyama T, Inoue D, Nishikawa K, Kobayashi M, Omura N,他 2名
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Journal Title
Peer Reviewed
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