2012 Fiscal Year Final Research Report
Prevention of ischemia-reperfusion liver injury through inhibiting the Platelets-Kuppfer cell interaction
| Project/Area Number |
22591499
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
KONDO Tadashi 筑波大学, 医学医療系, 准教授 (00375495)
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| Co-Investigator(Kenkyū-buntansha) |
OHKOHCHI Nobuhiro 筑波大学, 医学医療系, 教授 (40213673)
FUKUNAGA Kiyoshi 筑波大学, 医学医療系, 講師 (20361339)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 肝臓外科学 / 肝虚血再灌流 / 肝微小循環 |
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| Research Abstract |
Hepatic ischemiaereperfusion (I/R) leads to activation of Kupffer cells (KCs). We have evaluate the interaction between platelets and KCs in the hepatic microcirculation after I/R. In the I/R group, the number of adherent platelets increased significantly after I/R. More than 50% of the adherent platelets adhered to KCs. We succeeded in visualizing the dynamics of both KCs and platelets in the hepatic sinusoids. Liver ischemia induced the adhesion of platelets to KCs in the early period, which could play a key role in reperfusion injury of the liver.
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