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2012 Fiscal Year Final Research Report

The possibility of artificial myocardial assist system to support failed heart model.

Research Project

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Project/Area Number 22591534
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionTohoku University

Principal Investigator

AKIYAMA Masatoshi  東北大学, 病院, 講師 (80526450)

Co-Investigator(Kenkyū-buntansha) YANBE Tomoyuki  東北大学, 加齢医学研究所, 教授 (70241578)
SHIBUYA Takumi  東北大学, 大学院・医学系研究科, 非常勤講師 (10526453)
Project Period (FY) 2010 – 2012
Keywords心不全 / 僧帽弁閉鎖不全 / 低侵襲手術 / 人工心筋 / 心臓外科
Research Abstract

According to the results of our previous study, which was the hemodynamic support by artificial myocardium to the normal heart, the artificial myocardium was applied to the canine heart failure model induced by rapid ventricular pacing. However, its effect was not enough to improve hemodynamic parameters. The cause was suspected that the geometry of normal heart and failed heart was different. The wrapping pattern of artificial myocardium was studied using Mock circulation with the spherical sack, and the ideal pattern for failed heart was confirmed. We performed acute study using canine heart failure model again. The hemodynamic data was collected using the conductance catheter and echocardiography. The artificial myocardium led the increase of Emax value and the decrease of functional mitral regurgitation volume. These results support that the artificial myocardium could be the alternative therapy of advanced heart failure. In future, chronic evaluation of artificial myocardium is necessary for its effectiveness, durability, and safety.

  • Research Products

    (2 results)

All 2013 2012

All Presentation (2 results)

  • [Presentation] First Analysis Of Artificial Myocardium Applied To Chronic Heart Failure In Canine Model2013

    • Author(s)
      Yukihiro Hayatsu, Masatoshi Akiyama, Yasuyuki Shiraishi, Akihiro Yamada, Kazumasu Sasaki, Shunsuke Kawamoto,Tomoyuki Yambe, Yoshikatsu Saiki
    • Organizer
      ASAIO 59th Annual Conference(2013)
    • Place of Presentation
      シカゴ、米国
    • Year and Date
      20130612-15
  • [Presentation] 本間大極細形状記憶合金線維の多層化による人工心筋システムの改良2012

    • Author(s)
      白石泰之,山田昭博,Mohamed Hashem Omran,坪子侑佑,三浦英和,西條芳文,山家智之,秋山正年,早津幸弘,齋木佳克
    • Organizer
      2012年日本人工臓器学会
    • Place of Presentation
      福岡
    • Year and Date
      20121122-24

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Published: 2014-08-29  

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