2012 Fiscal Year Final Research Report
Development of scaffold-free heart valve using autologous cell
| Project/Area Number |
22591546
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Saga University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MORITA Shigeki 佐賀大学, 医学部, 教授 (70243938)
NODE Kouichi 佐賀大学, 医学部, 教授 (80359950)
NAKAYAMA Kouichi 佐賀大学, 工学系研究科, 教授 (50420609)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 心臓大血管外科 / 再生医療 / 心筋再生 / 組織工学 |
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| Research Abstract |
We fabricated scaffold-free 3-Dimensional cardiac valve structure using spheroid based technology. Proper vascular like tissue spheroids are fabricated with vascular smooth muscle cells, dermal fibroblasts, and vascular endothelial cells. We also fabricated 3-D heart valve structure with sinus of valsalva using robotic procedure. These structure contain rich extracelluar marix similar to native vascular and heart valve.
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